Calmodulin-Kinases: Modulators of Neuronal Development and Plasticity

Gary A. Wayman, Yong Seok Lee, Hiroshi Tokumitsu, Alcino Silva, Thomas R. Soderling

Research output: Contribution to journalArticle

382 Citations (Scopus)

Abstract

In the nervous system, many intracellular responses to elevated calcium are mediated by CaM kinases (CaMKs), a family of protein kinases whose activities are initially modulated by binding Ca2+/calmodulin and subsequently by protein phosphorylation. One member of this family, CaMKII, is well-established for its effects on modulating synaptic plasticity and learning and memory. However, recent studies indicate that some actions on neuronal development and function attributed to CaMKII may instead or in addition be mediated by other members of the CaMK cascade, such as CaMKK, CaMKI, and CaMKIV. This review summarizes key neuronal functions of the CaMK cascade in signal transduction, gene transcription, synaptic development and plasticity, and behavior. The technical challenges of mapping cellular protein kinase signaling pathways are also discussed.

Original languageEnglish
Pages (from-to)914-931
Number of pages18
JournalNeuron
Volume59
Issue number6
DOIs
Publication statusPublished - Sep 25 2008
Externally publishedYes

Fingerprint

Calcium-Calmodulin-Dependent Protein Kinases
Neuronal Plasticity
Calcium-Calmodulin-Dependent Protein Kinase Type 2
Phosphotransferases
Protein Kinases
Calcium-Calmodulin-Dependent Protein Kinase Kinase
Calmodulin
Nervous System
Signal Transduction
Phosphorylation
Learning
Calcium
Genes
Proteins

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Calmodulin-Kinases : Modulators of Neuronal Development and Plasticity. / Wayman, Gary A.; Lee, Yong Seok; Tokumitsu, Hiroshi; Silva, Alcino; Soderling, Thomas R.

In: Neuron, Vol. 59, No. 6, 25.09.2008, p. 914-931.

Research output: Contribution to journalArticle

Wayman, Gary A. ; Lee, Yong Seok ; Tokumitsu, Hiroshi ; Silva, Alcino ; Soderling, Thomas R. / Calmodulin-Kinases : Modulators of Neuronal Development and Plasticity. In: Neuron. 2008 ; Vol. 59, No. 6. pp. 914-931.
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