CGRP constitutes the calcitonin gene-related peptide (CGRP) family along with calcitonin, amylin, adrenomedullin, and calcitonin receptor-stimulating peptide. It consists of a single intramolecular ring structure and amidated C-terminus, which are common to the family members. CGRP is synthesized and released from sensory nerves in the central nervous system and gastrointestinal system. It dilates microvasculature in the CNS and is considered to transmit nociceptive signals during migraine. Stimulation of CGRP release is caused by the inflammatory substances in the CNS, and by the activation of capsaicin receptors in the gastrointestinal system. CGRP KO mice show high systolic blood pressure and reduced nociceptive hypersensitivity.
|Title of host publication||Handbook of Hormones|
|Subtitle of host publication||Comparative Endocrinology for Basic and Clinical Research|
|Publication status||Published - Jan 1 2015|
ASJC Scopus subject areas