Calcitonin gene-related peptide

Maho Ogoshi

doi:10.1016/B978-0-12-820649-2.00106-6

Calcitonin gene-related peptide

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

CGRP constitutes the calcitonin gene-related peptide (CGRP) family along with calcitonin (CT), amylin (AMY), adrenomedullin (AM), and calcitonin receptor-stimulating peptide (CRSP). It consists of a single intramolecular ring structure and an amidated C-terminus, which are common to the family members. CGRP is synthesized and released from sensory nerves in the CNS and gastrointestinal system. It dilates microvasculature in the CNS and is considered to transmit nociceptive signals during migraines. The stimulation of CGRP release is caused by the inflammatory substances in the CNS, and by the activation of the capsaicin receptors in the gastrointestinal system. Cgrp KO mice show high systolic blood pressure and reduced nociceptive hypersensitivity.

Original language	English
Title of host publication	Handbook of Hormones
Subtitle of host publication	Comparative Endocrinology for Basic and Clinical Research
Publisher	Elsevier
Pages	409-411
Number of pages	3
ISBN (Electronic)	9780128206492
DOIs	https://doi.org/10.1016/B978-0-12-820649-2.00106-6
Publication status	Published - Jan 1 2021

Keywords

Cardiovascular
Migraine
Neuropeptide
Vasodilation and microvasculature

ASJC Scopus subject areas

Medicine(all)

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10.1016/B978-0-12-820649-2.00106-6

Cite this

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title = "Calcitonin gene-related peptide",

abstract = "CGRP constitutes the calcitonin gene-related peptide (CGRP) family along with calcitonin (CT), amylin (AMY), adrenomedullin (AM), and calcitonin receptor-stimulating peptide (CRSP). It consists of a single intramolecular ring structure and an amidated C-terminus, which are common to the family members. CGRP is synthesized and released from sensory nerves in the CNS and gastrointestinal system. It dilates microvasculature in the CNS and is considered to transmit nociceptive signals during migraines. The stimulation of CGRP release is caused by the inflammatory substances in the CNS, and by the activation of the capsaicin receptors in the gastrointestinal system. Cgrp KO mice show high systolic blood pressure and reduced nociceptive hypersensitivity.",

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N2 - CGRP constitutes the calcitonin gene-related peptide (CGRP) family along with calcitonin (CT), amylin (AMY), adrenomedullin (AM), and calcitonin receptor-stimulating peptide (CRSP). It consists of a single intramolecular ring structure and an amidated C-terminus, which are common to the family members. CGRP is synthesized and released from sensory nerves in the CNS and gastrointestinal system. It dilates microvasculature in the CNS and is considered to transmit nociceptive signals during migraines. The stimulation of CGRP release is caused by the inflammatory substances in the CNS, and by the activation of the capsaicin receptors in the gastrointestinal system. Cgrp KO mice show high systolic blood pressure and reduced nociceptive hypersensitivity.

AB - CGRP constitutes the calcitonin gene-related peptide (CGRP) family along with calcitonin (CT), amylin (AMY), adrenomedullin (AM), and calcitonin receptor-stimulating peptide (CRSP). It consists of a single intramolecular ring structure and an amidated C-terminus, which are common to the family members. CGRP is synthesized and released from sensory nerves in the CNS and gastrointestinal system. It dilates microvasculature in the CNS and is considered to transmit nociceptive signals during migraines. The stimulation of CGRP release is caused by the inflammatory substances in the CNS, and by the activation of the capsaicin receptors in the gastrointestinal system. Cgrp KO mice show high systolic blood pressure and reduced nociceptive hypersensitivity.

KW - Cardiovascular

KW - Migraine

KW - Neuropeptide

KW - Vasodilation and microvasculature

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DO - 10.1016/B978-0-12-820649-2.00106-6

M3 - Chapter

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SP - 409

EP - 411

BT - Handbook of Hormones

PB - Elsevier

ER -

Calcitonin gene-related peptide

Abstract

Keywords

ASJC Scopus subject areas

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