Calcitonin gene-related peptide

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

CGRP constitutes the calcitonin gene-related peptide (CGRP) family along with calcitonin (CT), amylin (AMY), adrenomedullin (AM), and calcitonin receptor-stimulating peptide (CRSP). It consists of a single intramolecular ring structure and an amidated C-terminus, which are common to the family members. CGRP is synthesized and released from sensory nerves in the CNS and gastrointestinal system. It dilates microvasculature in the CNS and is considered to transmit nociceptive signals during migraines. The stimulation of CGRP release is caused by the inflammatory substances in the CNS, and by the activation of the capsaicin receptors in the gastrointestinal system. Cgrp KO mice show high systolic blood pressure and reduced nociceptive hypersensitivity.

Original languageEnglish
Title of host publicationHandbook of Hormones
Subtitle of host publicationComparative Endocrinology for Basic and Clinical Research
PublisherElsevier
Pages409-411
Number of pages3
ISBN (Electronic)9780128206492
DOIs
Publication statusPublished - Jan 1 2021

Keywords

  • Cardiovascular
  • Migraine
  • Neuropeptide
  • Vasodilation and microvasculature

ASJC Scopus subject areas

  • Medicine(all)

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