Calcineurin Plays Different Roles in Group II Metabotropic Glutamate Receptor- and NMDA Receptor-Dependent Long-Term Depression

Sheng Tian Li, Kunio Kato, Kazuhito Tomizawa, Masayuki Matsushita, Akiyoshi Moriwaki, Hideki Matsui, Katsuhiko Mikoshiba

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

We investigated metabotropic glutamate receptor (mGluR)-dependent long-term depression (LTD) in hippocampal CA1 pyramidal neurons of 6- to 8-d-old [postnatal days 6-8 (P6-P8)] and 21 - to 25-d-old (P21-P25) rats. In P6-P8 rats, induction of LTD depended on the activity of group II mGluRs. In P21-P25 rats, however, this LTD disappeared, and instead, NMDA receptor (NMDAR)-dependent LTD appeared. A bath containing a specific calcineurin (CaN) inhibitor restored the group II mGluR-dependent LTD in the neurons of the P21-P25 rats. Although postsynaptic injection of CaN inhibitors suppressed NMDAR-dependent LTD, it did not affect induction of group II mGluR-dependent LTD. These results demonstrate that CaN plays different roles in the induction of two forms of LTD: presynaptic CaN inhibits group II mGluR-dependent LTD, whereas postsyn-aptic CaN facilitates NMDAR-dependent LTD. These findings are the first demonstration in vitro of group II mGluR-dependent LTD that is negatively regulated by CaN via an age-dependent mechanism.

Original languageEnglish
Pages (from-to)5034-5041
Number of pages8
JournalJournal of Neuroscience
Volume22
Issue number12
Publication statusPublished - Jun 15 2002

Fingerprint

Metabotropic Glutamate Receptors
Calcineurin
N-Methyl-D-Aspartate Receptors
Pyramidal Cells
Baths
Neurons
Injections

Keywords

  • Hippocampus
  • Long-term potentiation
  • LTD
  • MGluR
  • NMDA receptor
  • Synaptic plasticity

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Li, S. T., Kato, K., Tomizawa, K., Matsushita, M., Moriwaki, A., Matsui, H., & Mikoshiba, K. (2002). Calcineurin Plays Different Roles in Group II Metabotropic Glutamate Receptor- and NMDA Receptor-Dependent Long-Term Depression. Journal of Neuroscience, 22(12), 5034-5041.

Calcineurin Plays Different Roles in Group II Metabotropic Glutamate Receptor- and NMDA Receptor-Dependent Long-Term Depression. / Li, Sheng Tian; Kato, Kunio; Tomizawa, Kazuhito; Matsushita, Masayuki; Moriwaki, Akiyoshi; Matsui, Hideki; Mikoshiba, Katsuhiko.

In: Journal of Neuroscience, Vol. 22, No. 12, 15.06.2002, p. 5034-5041.

Research output: Contribution to journalArticle

Li, ST, Kato, K, Tomizawa, K, Matsushita, M, Moriwaki, A, Matsui, H & Mikoshiba, K 2002, 'Calcineurin Plays Different Roles in Group II Metabotropic Glutamate Receptor- and NMDA Receptor-Dependent Long-Term Depression', Journal of Neuroscience, vol. 22, no. 12, pp. 5034-5041.
Li ST, Kato K, Tomizawa K, Matsushita M, Moriwaki A, Matsui H et al. Calcineurin Plays Different Roles in Group II Metabotropic Glutamate Receptor- and NMDA Receptor-Dependent Long-Term Depression. Journal of Neuroscience. 2002 Jun 15;22(12):5034-5041.
Li, Sheng Tian ; Kato, Kunio ; Tomizawa, Kazuhito ; Matsushita, Masayuki ; Moriwaki, Akiyoshi ; Matsui, Hideki ; Mikoshiba, Katsuhiko. / Calcineurin Plays Different Roles in Group II Metabotropic Glutamate Receptor- and NMDA Receptor-Dependent Long-Term Depression. In: Journal of Neuroscience. 2002 ; Vol. 22, No. 12. pp. 5034-5041.
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