Calcineurin inhibitor-induced irreversible neuropathic pain after allogeneic hematopoietic stem cell transplantation

Nobuharu Fujii, Kazuma Ikeda, Motoko Koyama, Kazutoshi Aoyama, Taro Masunari, Eisei Kondo, Takashi Matsuzaki, Satoshi Mizobuchi, Akio Hiraki, Takanori Teshima, Katsuji Shinagawa, Fumihiko Ishimaru, Mitsune Tanimoto

Research output: Contribution to journalArticlepeer-review

30 Citations (Scopus)


The calcineurin inhibitors (CIs) cyclosporine A and tacrolimus are essential for graft-versus-host disease prophylaxis but are associated with adverse effects, including neurotoxicity. We report a case of irreversible CI-induced neuropathic pain following allogeneic hematopoietic stem cell transplantation. The patient developed dysesthesia, electric shock-like pain, and severe itching followed by intractable analgesic-resistant pain in the lower extremities. There were no abnormal radiographic findings, and there was no improvement with a reduction of CI dosage or with administration of a calcium channel blocker. These clinical findings are similar to but inconsistent with CI-induced musculoskeletal pain syndromes previously reported in organ transplantation.

Original languageEnglish
Pages (from-to)459-461
Number of pages3
JournalInternational journal of hematology
Issue number5
Publication statusPublished - Jun 1 2006


  • Allogeneic hematopoietic stem cell transplantation
  • Calcineurin inhibitor
  • Dysesthesia
  • Itching
  • Neuropathic pain

ASJC Scopus subject areas

  • Hematology


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