Calbindin and calmodulin localization in the developing vestibular organ of the musk shrew (Suncus murinus)

Kenji Karita, Kazunori Nishizaki, Shigenobu Nomiya, Yu Masuda

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

The distribution of the Ca2+-binding proteins, calbindin and calmodulin, in the adult inner ear has been described previously. We undertook immunohistochemical investigation of developmental changes in the distribution of calbindin and calmodulin in the vestibular organ of the musk shrew (Suncus murinus). Expression of calbindin was seen first in the hair cells and the vestibular ganglion on gestational day (GD) 19, in nerve fibres on GD23 and in the otoconia on GD26. On GD19 calmodulin was demonstrable only in the hair cells. On GD26 both Ca2+-binding proteins showed a distribution of immunoreactivity in hair cells similar to that seen in adults. The developmental differences in distribution of these binding proteins may suggest different roles in the vestibule. Additionally, Ca2+-binding proteins may be a useful index of hair cell maturity.

Original languageEnglish
Pages (from-to)16-21
Number of pages6
JournalActa Oto-Laryngologica, Supplement
Issue number540
Publication statusPublished - 1999

Fingerprint

Shrews
Calbindins
Calmodulin
Carrier Proteins
Vestibular Hair Cells
Calmodulin-Binding Proteins
Otolithic Membrane
Inner Ear
Nerve Fibers
Ganglia
musk

Keywords

  • Calbindin
  • Calmodulin
  • Development
  • Inner ear
  • Suncus
  • Vestibule

ASJC Scopus subject areas

  • Otorhinolaryngology

Cite this

Calbindin and calmodulin localization in the developing vestibular organ of the musk shrew (Suncus murinus). / Karita, Kenji; Nishizaki, Kazunori; Nomiya, Shigenobu; Masuda, Yu.

In: Acta Oto-Laryngologica, Supplement, No. 540, 1999, p. 16-21.

Research output: Contribution to journalArticle

@article{2efad5c7e24348cea118d214de15dc11,
title = "Calbindin and calmodulin localization in the developing vestibular organ of the musk shrew (Suncus murinus)",
abstract = "The distribution of the Ca2+-binding proteins, calbindin and calmodulin, in the adult inner ear has been described previously. We undertook immunohistochemical investigation of developmental changes in the distribution of calbindin and calmodulin in the vestibular organ of the musk shrew (Suncus murinus). Expression of calbindin was seen first in the hair cells and the vestibular ganglion on gestational day (GD) 19, in nerve fibres on GD23 and in the otoconia on GD26. On GD19 calmodulin was demonstrable only in the hair cells. On GD26 both Ca2+-binding proteins showed a distribution of immunoreactivity in hair cells similar to that seen in adults. The developmental differences in distribution of these binding proteins may suggest different roles in the vestibule. Additionally, Ca2+-binding proteins may be a useful index of hair cell maturity.",
keywords = "Calbindin, Calmodulin, Development, Inner ear, Suncus, Vestibule",
author = "Kenji Karita and Kazunori Nishizaki and Shigenobu Nomiya and Yu Masuda",
year = "1999",
language = "English",
pages = "16--21",
journal = "Acta Oto-Laryngologica, Supplement",
issn = "0365-5237",
publisher = "Taylor and Francis Ltd.",
number = "540",

}

TY - JOUR

T1 - Calbindin and calmodulin localization in the developing vestibular organ of the musk shrew (Suncus murinus)

AU - Karita, Kenji

AU - Nishizaki, Kazunori

AU - Nomiya, Shigenobu

AU - Masuda, Yu

PY - 1999

Y1 - 1999

N2 - The distribution of the Ca2+-binding proteins, calbindin and calmodulin, in the adult inner ear has been described previously. We undertook immunohistochemical investigation of developmental changes in the distribution of calbindin and calmodulin in the vestibular organ of the musk shrew (Suncus murinus). Expression of calbindin was seen first in the hair cells and the vestibular ganglion on gestational day (GD) 19, in nerve fibres on GD23 and in the otoconia on GD26. On GD19 calmodulin was demonstrable only in the hair cells. On GD26 both Ca2+-binding proteins showed a distribution of immunoreactivity in hair cells similar to that seen in adults. The developmental differences in distribution of these binding proteins may suggest different roles in the vestibule. Additionally, Ca2+-binding proteins may be a useful index of hair cell maturity.

AB - The distribution of the Ca2+-binding proteins, calbindin and calmodulin, in the adult inner ear has been described previously. We undertook immunohistochemical investigation of developmental changes in the distribution of calbindin and calmodulin in the vestibular organ of the musk shrew (Suncus murinus). Expression of calbindin was seen first in the hair cells and the vestibular ganglion on gestational day (GD) 19, in nerve fibres on GD23 and in the otoconia on GD26. On GD19 calmodulin was demonstrable only in the hair cells. On GD26 both Ca2+-binding proteins showed a distribution of immunoreactivity in hair cells similar to that seen in adults. The developmental differences in distribution of these binding proteins may suggest different roles in the vestibule. Additionally, Ca2+-binding proteins may be a useful index of hair cell maturity.

KW - Calbindin

KW - Calmodulin

KW - Development

KW - Inner ear

KW - Suncus

KW - Vestibule

UR - http://www.scopus.com/inward/record.url?scp=0032588121&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0032588121&partnerID=8YFLogxK

M3 - Article

C2 - 10445073

AN - SCOPUS:0032588121

SP - 16

EP - 21

JO - Acta Oto-Laryngologica, Supplement

JF - Acta Oto-Laryngologica, Supplement

SN - 0365-5237

IS - 540

ER -