C-reactive protein levels and risk of disabling dementia with and without stroke in Japanese: The Circulatory Risk in Communities Study (CIRCS)

Choy Lye Chei, Kazumasa Yamagishi, Ai Ikeda, Hiroyuki Noda, Minako Maruyama, Renzhe Cui, Hironori Imano, Masahiko Kiyama, Akihiko Kitamura, Takashi Asada, Hiroyasu Iso, Masahiko Kiyama, Masakazu Nakamura, Takeo Okada, Kenji Maeda, Masatoshi Ido, Masayuki Yao, Mitsugu Kajiura, Yoshinori Ishikawa, Masamitsu KonishiTakashi Shimamoto, Hideki Ozawa, Minoru Iida, Yoshio Komach, Yoshihiko Naito, Shinichi Sato, Masakazu Nakamura, Tomoko Sankai, Kazumasa Yamagishi, Mitsumasa Umesawa, ChoyLye Chei, Minako Tabata, Hiroyasu Iso, Akihiko Kitamura, Hironori Imano, Renzhe Cui, Hiroyuki Noda, Satoyo Ikehara, Yuji Shimizu, Isao Muraki, Masanori Nagao, Minako Maruyama, Takeshi Tanigawa, Ai Ikeda, Tetsuya Ohira, Isao Saito, Susumu Sakurai, Shinichi Hitsumoto, Kotatsu Maruyama, Eri Eguchi

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Objective: Studies have shown that elevated high-sensitivity C-reactive protein (hs-CRP) predicts stroke, which is a risk factor for dementia. It remains, however, unclear whether hs-CRP increases risk of dementia. Methods: A prospective nested case-control study of Japanese 40-69 years of age was conducted using frozen serum samples collected from approximately 7531men and women who participated in cardiovascular risk surveys from 1984 to 1994 in one community and 1989-1995 in another community under the Circulatory Risk in Communities Study (CIRCS). Two control subjects per case were matched by sex, age, community, and year of serum storage. The hs-CRP was measured using a latex particle-enhanced immunonephelometric assay. Results: Between 1999 and 2013, we identified 275 disabling dementia cases (96 cases with history of stroke and 179 without it). There was a positive association between hs-CRP levels and risk of dementia with history of stroke. No significant association was observed between hs-CRP levels and risk of dementia without history of stroke. After adjustment for hypertension, diabetes and other confounding variables, the positive association remained statistically significant. The multivariable odds ratios associated with 1-SD increment of log hs-CRP were 1.02 (0.87-1.20) for total dementia, 1.35 (1.02-1.79) for dementia with history of stroke, and 0.89 (0.72-1.10) for dementia without history of stroke. Conclusion: Elevated hs-CRP levels were associated with increased risk of disabling dementia in individuals with history of stroke but not in those without it.

Original languageEnglish
Pages (from-to)438-443
Number of pages6
JournalAtherosclerosis
Volume236
Issue number2
DOIs
Publication statusPublished - Aug 12 2014
Externally publishedYes

Fingerprint

C-Reactive Protein
Dementia
Stroke
Confounding Factors (Epidemiology)
Serum
Microspheres
Case-Control Studies
Odds Ratio
Hypertension

Keywords

  • Dementia
  • Hs-CRP
  • Japanese
  • Stroke

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

C-reactive protein levels and risk of disabling dementia with and without stroke in Japanese : The Circulatory Risk in Communities Study (CIRCS). / Chei, Choy Lye; Yamagishi, Kazumasa; Ikeda, Ai; Noda, Hiroyuki; Maruyama, Minako; Cui, Renzhe; Imano, Hironori; Kiyama, Masahiko; Kitamura, Akihiko; Asada, Takashi; Iso, Hiroyasu; Kiyama, Masahiko; Nakamura, Masakazu; Okada, Takeo; Maeda, Kenji; Ido, Masatoshi; Yao, Masayuki; Kajiura, Mitsugu; Ishikawa, Yoshinori; Konishi, Masamitsu; Shimamoto, Takashi; Ozawa, Hideki; Iida, Minoru; Komach, Yoshio; Naito, Yoshihiko; Sato, Shinichi; Nakamura, Masakazu; Sankai, Tomoko; Yamagishi, Kazumasa; Umesawa, Mitsumasa; Chei, ChoyLye; Tabata, Minako; Iso, Hiroyasu; Kitamura, Akihiko; Imano, Hironori; Cui, Renzhe; Noda, Hiroyuki; Ikehara, Satoyo; Shimizu, Yuji; Muraki, Isao; Nagao, Masanori; Maruyama, Minako; Tanigawa, Takeshi; Ikeda, Ai; Ohira, Tetsuya; Saito, Isao; Sakurai, Susumu; Hitsumoto, Shinichi; Maruyama, Kotatsu; Eguchi, Eri.

In: Atherosclerosis, Vol. 236, No. 2, 12.08.2014, p. 438-443.

Research output: Contribution to journalArticle

Chei, CL, Yamagishi, K, Ikeda, A, Noda, H, Maruyama, M, Cui, R, Imano, H, Kiyama, M, Kitamura, A, Asada, T, Iso, H, Kiyama, M, Nakamura, M, Okada, T, Maeda, K, Ido, M, Yao, M, Kajiura, M, Ishikawa, Y, Konishi, M, Shimamoto, T, Ozawa, H, Iida, M, Komach, Y, Naito, Y, Sato, S, Nakamura, M, Sankai, T, Yamagishi, K, Umesawa, M, Chei, C, Tabata, M, Iso, H, Kitamura, A, Imano, H, Cui, R, Noda, H, Ikehara, S, Shimizu, Y, Muraki, I, Nagao, M, Maruyama, M, Tanigawa, T, Ikeda, A, Ohira, T, Saito, I, Sakurai, S, Hitsumoto, S, Maruyama, K & Eguchi, E 2014, 'C-reactive protein levels and risk of disabling dementia with and without stroke in Japanese: The Circulatory Risk in Communities Study (CIRCS)', Atherosclerosis, vol. 236, no. 2, pp. 438-443. https://doi.org/10.1016/j.atherosclerosis.2014.07.036
Chei, Choy Lye ; Yamagishi, Kazumasa ; Ikeda, Ai ; Noda, Hiroyuki ; Maruyama, Minako ; Cui, Renzhe ; Imano, Hironori ; Kiyama, Masahiko ; Kitamura, Akihiko ; Asada, Takashi ; Iso, Hiroyasu ; Kiyama, Masahiko ; Nakamura, Masakazu ; Okada, Takeo ; Maeda, Kenji ; Ido, Masatoshi ; Yao, Masayuki ; Kajiura, Mitsugu ; Ishikawa, Yoshinori ; Konishi, Masamitsu ; Shimamoto, Takashi ; Ozawa, Hideki ; Iida, Minoru ; Komach, Yoshio ; Naito, Yoshihiko ; Sato, Shinichi ; Nakamura, Masakazu ; Sankai, Tomoko ; Yamagishi, Kazumasa ; Umesawa, Mitsumasa ; Chei, ChoyLye ; Tabata, Minako ; Iso, Hiroyasu ; Kitamura, Akihiko ; Imano, Hironori ; Cui, Renzhe ; Noda, Hiroyuki ; Ikehara, Satoyo ; Shimizu, Yuji ; Muraki, Isao ; Nagao, Masanori ; Maruyama, Minako ; Tanigawa, Takeshi ; Ikeda, Ai ; Ohira, Tetsuya ; Saito, Isao ; Sakurai, Susumu ; Hitsumoto, Shinichi ; Maruyama, Kotatsu ; Eguchi, Eri. / C-reactive protein levels and risk of disabling dementia with and without stroke in Japanese : The Circulatory Risk in Communities Study (CIRCS). In: Atherosclerosis. 2014 ; Vol. 236, No. 2. pp. 438-443.
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T1 - C-reactive protein levels and risk of disabling dementia with and without stroke in Japanese

T2 - The Circulatory Risk in Communities Study (CIRCS)

AU - Chei, Choy Lye

AU - Yamagishi, Kazumasa

AU - Ikeda, Ai

AU - Noda, Hiroyuki

AU - Maruyama, Minako

AU - Cui, Renzhe

AU - Imano, Hironori

AU - Kiyama, Masahiko

AU - Kitamura, Akihiko

AU - Asada, Takashi

AU - Iso, Hiroyasu

AU - Kiyama, Masahiko

AU - Nakamura, Masakazu

AU - Okada, Takeo

AU - Maeda, Kenji

AU - Ido, Masatoshi

AU - Yao, Masayuki

AU - Kajiura, Mitsugu

AU - Ishikawa, Yoshinori

AU - Konishi, Masamitsu

AU - Shimamoto, Takashi

AU - Ozawa, Hideki

AU - Iida, Minoru

AU - Komach, Yoshio

AU - Naito, Yoshihiko

AU - Sato, Shinichi

AU - Nakamura, Masakazu

AU - Sankai, Tomoko

AU - Yamagishi, Kazumasa

AU - Umesawa, Mitsumasa

AU - Chei, ChoyLye

AU - Tabata, Minako

AU - Iso, Hiroyasu

AU - Kitamura, Akihiko

AU - Imano, Hironori

AU - Cui, Renzhe

AU - Noda, Hiroyuki

AU - Ikehara, Satoyo

AU - Shimizu, Yuji

AU - Muraki, Isao

AU - Nagao, Masanori

AU - Maruyama, Minako

AU - Tanigawa, Takeshi

AU - Ikeda, Ai

AU - Ohira, Tetsuya

AU - Saito, Isao

AU - Sakurai, Susumu

AU - Hitsumoto, Shinichi

AU - Maruyama, Kotatsu

AU - Eguchi, Eri

PY - 2014/8/12

Y1 - 2014/8/12

N2 - Objective: Studies have shown that elevated high-sensitivity C-reactive protein (hs-CRP) predicts stroke, which is a risk factor for dementia. It remains, however, unclear whether hs-CRP increases risk of dementia. Methods: A prospective nested case-control study of Japanese 40-69 years of age was conducted using frozen serum samples collected from approximately 7531men and women who participated in cardiovascular risk surveys from 1984 to 1994 in one community and 1989-1995 in another community under the Circulatory Risk in Communities Study (CIRCS). Two control subjects per case were matched by sex, age, community, and year of serum storage. The hs-CRP was measured using a latex particle-enhanced immunonephelometric assay. Results: Between 1999 and 2013, we identified 275 disabling dementia cases (96 cases with history of stroke and 179 without it). There was a positive association between hs-CRP levels and risk of dementia with history of stroke. No significant association was observed between hs-CRP levels and risk of dementia without history of stroke. After adjustment for hypertension, diabetes and other confounding variables, the positive association remained statistically significant. The multivariable odds ratios associated with 1-SD increment of log hs-CRP were 1.02 (0.87-1.20) for total dementia, 1.35 (1.02-1.79) for dementia with history of stroke, and 0.89 (0.72-1.10) for dementia without history of stroke. Conclusion: Elevated hs-CRP levels were associated with increased risk of disabling dementia in individuals with history of stroke but not in those without it.

AB - Objective: Studies have shown that elevated high-sensitivity C-reactive protein (hs-CRP) predicts stroke, which is a risk factor for dementia. It remains, however, unclear whether hs-CRP increases risk of dementia. Methods: A prospective nested case-control study of Japanese 40-69 years of age was conducted using frozen serum samples collected from approximately 7531men and women who participated in cardiovascular risk surveys from 1984 to 1994 in one community and 1989-1995 in another community under the Circulatory Risk in Communities Study (CIRCS). Two control subjects per case were matched by sex, age, community, and year of serum storage. The hs-CRP was measured using a latex particle-enhanced immunonephelometric assay. Results: Between 1999 and 2013, we identified 275 disabling dementia cases (96 cases with history of stroke and 179 without it). There was a positive association between hs-CRP levels and risk of dementia with history of stroke. No significant association was observed between hs-CRP levels and risk of dementia without history of stroke. After adjustment for hypertension, diabetes and other confounding variables, the positive association remained statistically significant. The multivariable odds ratios associated with 1-SD increment of log hs-CRP were 1.02 (0.87-1.20) for total dementia, 1.35 (1.02-1.79) for dementia with history of stroke, and 0.89 (0.72-1.10) for dementia without history of stroke. Conclusion: Elevated hs-CRP levels were associated with increased risk of disabling dementia in individuals with history of stroke but not in those without it.

KW - Dementia

KW - Hs-CRP

KW - Japanese

KW - Stroke

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