Abstract
Objective: Studies have shown that elevated high-sensitivity C-reactive protein (hs-CRP) predicts stroke, which is a risk factor for dementia. It remains, however, unclear whether hs-CRP increases risk of dementia. Methods: A prospective nested case-control study of Japanese 40-69 years of age was conducted using frozen serum samples collected from approximately 7531men and women who participated in cardiovascular risk surveys from 1984 to 1994 in one community and 1989-1995 in another community under the Circulatory Risk in Communities Study (CIRCS). Two control subjects per case were matched by sex, age, community, and year of serum storage. The hs-CRP was measured using a latex particle-enhanced immunonephelometric assay. Results: Between 1999 and 2013, we identified 275 disabling dementia cases (96 cases with history of stroke and 179 without it). There was a positive association between hs-CRP levels and risk of dementia with history of stroke. No significant association was observed between hs-CRP levels and risk of dementia without history of stroke. After adjustment for hypertension, diabetes and other confounding variables, the positive association remained statistically significant. The multivariable odds ratios associated with 1-SD increment of log hs-CRP were 1.02 (0.87-1.20) for total dementia, 1.35 (1.02-1.79) for dementia with history of stroke, and 0.89 (0.72-1.10) for dementia without history of stroke. Conclusion: Elevated hs-CRP levels were associated with increased risk of disabling dementia in individuals with history of stroke but not in those without it.
| Original language | English |
|---|---|
| Pages (from-to) | 438-443 |
| Number of pages | 6 |
| Journal | Atherosclerosis |
| Volume | 236 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - Aug 12 2014 |
| Externally published | Yes |
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Keywords
- Dementia
- Hs-CRP
- Japanese
- Stroke
ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine
Cite this
C-reactive protein levels and risk of disabling dementia with and without stroke in Japanese : The Circulatory Risk in Communities Study (CIRCS). / Chei, Choy Lye; Yamagishi, Kazumasa; Ikeda, Ai; Noda, Hiroyuki; Maruyama, Minako; Cui, Renzhe; Imano, Hironori; Kiyama, Masahiko; Kitamura, Akihiko; Asada, Takashi; Iso, Hiroyasu; Kiyama, Masahiko; Nakamura, Masakazu; Okada, Takeo; Maeda, Kenji; Ido, Masatoshi; Yao, Masayuki; Kajiura, Mitsugu; Ishikawa, Yoshinori; Konishi, Masamitsu; Shimamoto, Takashi; Ozawa, Hideki; Iida, Minoru; Komach, Yoshio; Naito, Yoshihiko; Sato, Shinichi; Nakamura, Masakazu; Sankai, Tomoko; Yamagishi, Kazumasa; Umesawa, Mitsumasa; Chei, ChoyLye; Tabata, Minako; Iso, Hiroyasu; Kitamura, Akihiko; Imano, Hironori; Cui, Renzhe; Noda, Hiroyuki; Ikehara, Satoyo; Shimizu, Yuji; Muraki, Isao; Nagao, Masanori; Maruyama, Minako; Tanigawa, Takeshi; Ikeda, Ai; Ohira, Tetsuya; Saito, Isao; Sakurai, Susumu; Hitsumoto, Shinichi; Maruyama, Kotatsu; Eguchi, Eri.
In: Atherosclerosis, Vol. 236, No. 2, 12.08.2014, p. 438-443.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - C-reactive protein levels and risk of disabling dementia with and without stroke in Japanese
T2 - The Circulatory Risk in Communities Study (CIRCS)
AU - Chei, Choy Lye
AU - Yamagishi, Kazumasa
AU - Ikeda, Ai
AU - Noda, Hiroyuki
AU - Maruyama, Minako
AU - Cui, Renzhe
AU - Imano, Hironori
AU - Kiyama, Masahiko
AU - Kitamura, Akihiko
AU - Asada, Takashi
AU - Iso, Hiroyasu
AU - Kiyama, Masahiko
AU - Nakamura, Masakazu
AU - Okada, Takeo
AU - Maeda, Kenji
AU - Ido, Masatoshi
AU - Yao, Masayuki
AU - Kajiura, Mitsugu
AU - Ishikawa, Yoshinori
AU - Konishi, Masamitsu
AU - Shimamoto, Takashi
AU - Ozawa, Hideki
AU - Iida, Minoru
AU - Komach, Yoshio
AU - Naito, Yoshihiko
AU - Sato, Shinichi
AU - Nakamura, Masakazu
AU - Sankai, Tomoko
AU - Yamagishi, Kazumasa
AU - Umesawa, Mitsumasa
AU - Chei, ChoyLye
AU - Tabata, Minako
AU - Iso, Hiroyasu
AU - Kitamura, Akihiko
AU - Imano, Hironori
AU - Cui, Renzhe
AU - Noda, Hiroyuki
AU - Ikehara, Satoyo
AU - Shimizu, Yuji
AU - Muraki, Isao
AU - Nagao, Masanori
AU - Maruyama, Minako
AU - Tanigawa, Takeshi
AU - Ikeda, Ai
AU - Ohira, Tetsuya
AU - Saito, Isao
AU - Sakurai, Susumu
AU - Hitsumoto, Shinichi
AU - Maruyama, Kotatsu
AU - Eguchi, Eri
PY - 2014/8/12
Y1 - 2014/8/12
N2 - Objective: Studies have shown that elevated high-sensitivity C-reactive protein (hs-CRP) predicts stroke, which is a risk factor for dementia. It remains, however, unclear whether hs-CRP increases risk of dementia. Methods: A prospective nested case-control study of Japanese 40-69 years of age was conducted using frozen serum samples collected from approximately 7531men and women who participated in cardiovascular risk surveys from 1984 to 1994 in one community and 1989-1995 in another community under the Circulatory Risk in Communities Study (CIRCS). Two control subjects per case were matched by sex, age, community, and year of serum storage. The hs-CRP was measured using a latex particle-enhanced immunonephelometric assay. Results: Between 1999 and 2013, we identified 275 disabling dementia cases (96 cases with history of stroke and 179 without it). There was a positive association between hs-CRP levels and risk of dementia with history of stroke. No significant association was observed between hs-CRP levels and risk of dementia without history of stroke. After adjustment for hypertension, diabetes and other confounding variables, the positive association remained statistically significant. The multivariable odds ratios associated with 1-SD increment of log hs-CRP were 1.02 (0.87-1.20) for total dementia, 1.35 (1.02-1.79) for dementia with history of stroke, and 0.89 (0.72-1.10) for dementia without history of stroke. Conclusion: Elevated hs-CRP levels were associated with increased risk of disabling dementia in individuals with history of stroke but not in those without it.
AB - Objective: Studies have shown that elevated high-sensitivity C-reactive protein (hs-CRP) predicts stroke, which is a risk factor for dementia. It remains, however, unclear whether hs-CRP increases risk of dementia. Methods: A prospective nested case-control study of Japanese 40-69 years of age was conducted using frozen serum samples collected from approximately 7531men and women who participated in cardiovascular risk surveys from 1984 to 1994 in one community and 1989-1995 in another community under the Circulatory Risk in Communities Study (CIRCS). Two control subjects per case were matched by sex, age, community, and year of serum storage. The hs-CRP was measured using a latex particle-enhanced immunonephelometric assay. Results: Between 1999 and 2013, we identified 275 disabling dementia cases (96 cases with history of stroke and 179 without it). There was a positive association between hs-CRP levels and risk of dementia with history of stroke. No significant association was observed between hs-CRP levels and risk of dementia without history of stroke. After adjustment for hypertension, diabetes and other confounding variables, the positive association remained statistically significant. The multivariable odds ratios associated with 1-SD increment of log hs-CRP were 1.02 (0.87-1.20) for total dementia, 1.35 (1.02-1.79) for dementia with history of stroke, and 0.89 (0.72-1.10) for dementia without history of stroke. Conclusion: Elevated hs-CRP levels were associated with increased risk of disabling dementia in individuals with history of stroke but not in those without it.
KW - Dementia
KW - Hs-CRP
KW - Japanese
KW - Stroke
UR - http://www.scopus.com/inward/record.url?scp=84907070485&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84907070485&partnerID=8YFLogxK
U2 - 10.1016/j.atherosclerosis.2014.07.036
DO - 10.1016/j.atherosclerosis.2014.07.036
M3 - Article
C2 - 25171778
AN - SCOPUS:84907070485
VL - 236
SP - 438
EP - 443
JO - Atherosclerosis
JF - Atherosclerosis
SN - 0021-9150
IS - 2
ER -