C-reactive protein is associated with cigarette smoking-induced hyperfiltration and proteinuria in an apparently healthy population

Rani Sauriasari, Noriko Sakano, Da Hong Wang, Jiro Takaki, Kei Takemoto, Bingling Wang, Hitoshi Sugiyama, Yoshie Sato, Tomoko Takigawa, Noriko Takahashi, Sakiko Kanbara, Yoshiaki Hitomi, Hiroyuki Nakamura, Keiki Ogino

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Although cigarette smoking is known to be an important risk factor for renal disease, the mechanism by which smoking induces progressive renal disease in a healthy population has not been established. We hypothesized that oxidative stress (measured as 8-iso-prostaglandin F 2α, 8-iso-PGF2a), inflammation (highly sensitive C-reactive protein (CRP), hs-CRP) and nitric oxide may be associated with an alteration in the estimated glomerular filtration rate (eGFR) and proteinuria in otherwise healthy smokers. A total of 649 eligible subjects were classified according to their smoking status. Plasma NOx was measured using ozone-based chemiluminescence, urinary 8-iso-PGF2a was measured using enzyme immunoassay and serum hs-CRP was measured using a latex aggregation nephelometry method. The levels of 8-iso-PGF2a and hs-CRP increased in current smokers (P

Original languageEnglish
Pages (from-to)1129-1136
Number of pages8
JournalHypertension Research
Volume33
Issue number11
DOIs
Publication statusPublished - Nov 2010

Fingerprint

Proteinuria
C-Reactive Protein
Smoking
Population
Nephelometry and Turbidimetry
Kidney
Ozone
Latex
Prostaglandins F
Luminescence
Protein C
Glomerular Filtration Rate
Immunoenzyme Techniques
Nitric Oxide
Oxidative Stress
Inflammation
Serum

Keywords

  • 8-iso-PGF2a
  • Cigarette smoking
  • hs-CRP
  • nitric oxide
  • renal function

ASJC Scopus subject areas

  • Internal Medicine
  • Physiology
  • Cardiology and Cardiovascular Medicine

Cite this

C-reactive protein is associated with cigarette smoking-induced hyperfiltration and proteinuria in an apparently healthy population. / Sauriasari, Rani; Sakano, Noriko; Wang, Da Hong; Takaki, Jiro; Takemoto, Kei; Wang, Bingling; Sugiyama, Hitoshi; Sato, Yoshie; Takigawa, Tomoko; Takahashi, Noriko; Kanbara, Sakiko; Hitomi, Yoshiaki; Nakamura, Hiroyuki; Ogino, Keiki.

In: Hypertension Research, Vol. 33, No. 11, 11.2010, p. 1129-1136.

Research output: Contribution to journalArticle

Sauriasari, R, Sakano, N, Wang, DH, Takaki, J, Takemoto, K, Wang, B, Sugiyama, H, Sato, Y, Takigawa, T, Takahashi, N, Kanbara, S, Hitomi, Y, Nakamura, H & Ogino, K 2010, 'C-reactive protein is associated with cigarette smoking-induced hyperfiltration and proteinuria in an apparently healthy population', Hypertension Research, vol. 33, no. 11, pp. 1129-1136. https://doi.org/10.1038/hr.2010.154
Sauriasari, Rani ; Sakano, Noriko ; Wang, Da Hong ; Takaki, Jiro ; Takemoto, Kei ; Wang, Bingling ; Sugiyama, Hitoshi ; Sato, Yoshie ; Takigawa, Tomoko ; Takahashi, Noriko ; Kanbara, Sakiko ; Hitomi, Yoshiaki ; Nakamura, Hiroyuki ; Ogino, Keiki. / C-reactive protein is associated with cigarette smoking-induced hyperfiltration and proteinuria in an apparently healthy population. In: Hypertension Research. 2010 ; Vol. 33, No. 11. pp. 1129-1136.
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