TY - JOUR
T1 - C-reactive protein and cardiovascular disease in east asians
T2 - A systematic review
AU - Saito, Isao
AU - Maruyama, Koutatsu
AU - Eguchi, Eri
N1 - Publisher Copyright:
© the authors, publisher and licensee Libertas Academica Limited.
PY - 2014/12/13
Y1 - 2014/12/13
N2 - Elevated C-reactive protein (CRP) levels are associated with an increased risk of cardiovascular disease (CVD) in Caucasians; however, evidence is lacking for East Asians, who have low CRP levels. PubMed and Google Scholar searches were conducted (1966 through September 2014), and eight prospective studies in East Asian countries (China, Hong Kong, Japan, Korea, Macao, Mongolia, and Taiwan) that documented risk ratios of elevated CRP for CVD were included for meta-analysis with random-effects models. The overall association between CRP levels and stroke was significant in six studies (risk ratio = 1.40 [95% confidence interval {CI}, 1.10–1.77], P = 0.008). The association with ischemic stroke was more evident in subgroup analyses. For coronary heart disease (CHD) and CVD, the risk ratio was 1.75 (95% CI, 0.96–3.19, P = 0.07) and 1.76 (95% CI, 1.29–2.40, P, 0.001), respectively. Although East Asians have low CRP levels, this meta-analysis shows that elevated CRP levels were significantly associated with an increased risk of stroke, primarily ischemic stroke.
AB - Elevated C-reactive protein (CRP) levels are associated with an increased risk of cardiovascular disease (CVD) in Caucasians; however, evidence is lacking for East Asians, who have low CRP levels. PubMed and Google Scholar searches were conducted (1966 through September 2014), and eight prospective studies in East Asian countries (China, Hong Kong, Japan, Korea, Macao, Mongolia, and Taiwan) that documented risk ratios of elevated CRP for CVD were included for meta-analysis with random-effects models. The overall association between CRP levels and stroke was significant in six studies (risk ratio = 1.40 [95% confidence interval {CI}, 1.10–1.77], P = 0.008). The association with ischemic stroke was more evident in subgroup analyses. For coronary heart disease (CHD) and CVD, the risk ratio was 1.75 (95% CI, 0.96–3.19, P = 0.07) and 1.76 (95% CI, 1.29–2.40, P, 0.001), respectively. Although East Asians have low CRP levels, this meta-analysis shows that elevated CRP levels were significantly associated with an increased risk of stroke, primarily ischemic stroke.
KW - C-reactive protein
KW - Cardiovascular disease
KW - East Asia
KW - Systematic review
UR - http://www.scopus.com/inward/record.url?scp=84981703918&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84981703918&partnerID=8YFLogxK
U2 - 10.4137/CMC.S17066
DO - 10.4137/CMC.S17066
M3 - Review article
AN - SCOPUS:84981703918
VL - 8
SP - 35
EP - 42
JO - Clinical Medicine Insights: Cardiology
JF - Clinical Medicine Insights: Cardiology
SN - 1179-5468
IS - Suppl. 3
ER -
