C-reactive protein and cardiovascular disease in east asians: A systematic review

Isao Saito, Koutatsu Maruyama, Eri Eguchi

Research output: Contribution to journalReview articlepeer-review

25 Citations (Scopus)


Elevated C-reactive protein (CRP) levels are associated with an increased risk of cardiovascular disease (CVD) in Caucasians; however, evidence is lacking for East Asians, who have low CRP levels. PubMed and Google Scholar searches were conducted (1966 through September 2014), and eight prospective studies in East Asian countries (China, Hong Kong, Japan, Korea, Macao, Mongolia, and Taiwan) that documented risk ratios of elevated CRP for CVD were included for meta-analysis with random-effects models. The overall association between CRP levels and stroke was significant in six studies (risk ratio = 1.40 [95% confidence interval {CI}, 1.10–1.77], P = 0.008). The association with ischemic stroke was more evident in subgroup analyses. For coronary heart disease (CHD) and CVD, the risk ratio was 1.75 (95% CI, 0.96–3.19, P = 0.07) and 1.76 (95% CI, 1.29–2.40, P, 0.001), respectively. Although East Asians have low CRP levels, this meta-analysis shows that elevated CRP levels were significantly associated with an increased risk of stroke, primarily ischemic stroke.

Original languageEnglish
Pages (from-to)35-42
Number of pages8
JournalClinical Medicine Insights: Cardiology
Issue numberSuppl. 3
Publication statusPublished - Dec 13 2014
Externally publishedYes


  • C-reactive protein
  • Cardiovascular disease
  • East Asia
  • Systematic review

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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