c-Fos Induction in the Subnucleus Caudalis Following Noxious Mechanical Stimulation of the Oral Mucous Membrane

Tomosada Sugimoto, Tetsuya Hara, Hajime Shirai, Toshihiko Abe, Hiroyuki Ichikawa, Takashi Sato

Research output: Contribution to journalArticle

46 Citations (Scopus)

Abstract

c-fos expression in response to noxious mechanical stimulation of the peripheral receptive field was used to study the somatotopic representation of the oral mucous membrane and trigeminal cutaneous receptive fields in the trigeminal subnucleus caudalis and the cervical spinal dorsal horn. Fos-neurons (neurons with c-fos protein-like immunoreactivity) following stimulation of the cutaneous receptive field were found in laminae I and II of the first and second cervical segments of the spinal cord ipsilateral to the stimulation and exhibited a clear somatotopic segregation; i.e., the fos-neurons responding to receptive fields in the mandibular, maxillary, and ophthalmic divisions were arranged in a mediolateral sequence. On the other hand, fos-neurons responding to the oral mucous membrane were found in the similar laminae of the rostral pole of subnucleus caudalis bilaterally. They were all found in the dorsalmost part of the subnucleus without segregation; e.g., topographic distributions of fos-neurons resulting from the mandibular and maxillary gingival stimulations were indistinguishable. The central mechanism of trigeminal nociception is discussed with respect to the difference between intra- and extraoral receptive fields.

Original languageEnglish
Pages (from-to)251-256
Number of pages6
JournalExperimental Neurology
Volume129
Issue number2
DOIs
Publication statusPublished - Oct 1994

Fingerprint

Mucous Membrane
Neurons
Substantia Gelatinosa
Proto-Oncogene Proteins c-fos
Skin
Nociception
Spinal Cord Dorsal Horn

ASJC Scopus subject areas

  • Neurology
  • Neuroscience(all)

Cite this

c-Fos Induction in the Subnucleus Caudalis Following Noxious Mechanical Stimulation of the Oral Mucous Membrane. / Sugimoto, Tomosada; Hara, Tetsuya; Shirai, Hajime; Abe, Toshihiko; Ichikawa, Hiroyuki; Sato, Takashi.

In: Experimental Neurology, Vol. 129, No. 2, 10.1994, p. 251-256.

Research output: Contribution to journalArticle

Sugimoto, Tomosada ; Hara, Tetsuya ; Shirai, Hajime ; Abe, Toshihiko ; Ichikawa, Hiroyuki ; Sato, Takashi. / c-Fos Induction in the Subnucleus Caudalis Following Noxious Mechanical Stimulation of the Oral Mucous Membrane. In: Experimental Neurology. 1994 ; Vol. 129, No. 2. pp. 251-256.
@article{a1a9467bc10940b4812bf62b04d0c79e,
title = "c-Fos Induction in the Subnucleus Caudalis Following Noxious Mechanical Stimulation of the Oral Mucous Membrane",
abstract = "c-fos expression in response to noxious mechanical stimulation of the peripheral receptive field was used to study the somatotopic representation of the oral mucous membrane and trigeminal cutaneous receptive fields in the trigeminal subnucleus caudalis and the cervical spinal dorsal horn. Fos-neurons (neurons with c-fos protein-like immunoreactivity) following stimulation of the cutaneous receptive field were found in laminae I and II of the first and second cervical segments of the spinal cord ipsilateral to the stimulation and exhibited a clear somatotopic segregation; i.e., the fos-neurons responding to receptive fields in the mandibular, maxillary, and ophthalmic divisions were arranged in a mediolateral sequence. On the other hand, fos-neurons responding to the oral mucous membrane were found in the similar laminae of the rostral pole of subnucleus caudalis bilaterally. They were all found in the dorsalmost part of the subnucleus without segregation; e.g., topographic distributions of fos-neurons resulting from the mandibular and maxillary gingival stimulations were indistinguishable. The central mechanism of trigeminal nociception is discussed with respect to the difference between intra- and extraoral receptive fields.",
author = "Tomosada Sugimoto and Tetsuya Hara and Hajime Shirai and Toshihiko Abe and Hiroyuki Ichikawa and Takashi Sato",
year = "1994",
month = "10",
doi = "10.1006/exnr.1994.1167",
language = "English",
volume = "129",
pages = "251--256",
journal = "Experimental Neurology",
issn = "0014-4886",
publisher = "Academic Press Inc.",
number = "2",

}

TY - JOUR

T1 - c-Fos Induction in the Subnucleus Caudalis Following Noxious Mechanical Stimulation of the Oral Mucous Membrane

AU - Sugimoto, Tomosada

AU - Hara, Tetsuya

AU - Shirai, Hajime

AU - Abe, Toshihiko

AU - Ichikawa, Hiroyuki

AU - Sato, Takashi

PY - 1994/10

Y1 - 1994/10

N2 - c-fos expression in response to noxious mechanical stimulation of the peripheral receptive field was used to study the somatotopic representation of the oral mucous membrane and trigeminal cutaneous receptive fields in the trigeminal subnucleus caudalis and the cervical spinal dorsal horn. Fos-neurons (neurons with c-fos protein-like immunoreactivity) following stimulation of the cutaneous receptive field were found in laminae I and II of the first and second cervical segments of the spinal cord ipsilateral to the stimulation and exhibited a clear somatotopic segregation; i.e., the fos-neurons responding to receptive fields in the mandibular, maxillary, and ophthalmic divisions were arranged in a mediolateral sequence. On the other hand, fos-neurons responding to the oral mucous membrane were found in the similar laminae of the rostral pole of subnucleus caudalis bilaterally. They were all found in the dorsalmost part of the subnucleus without segregation; e.g., topographic distributions of fos-neurons resulting from the mandibular and maxillary gingival stimulations were indistinguishable. The central mechanism of trigeminal nociception is discussed with respect to the difference between intra- and extraoral receptive fields.

AB - c-fos expression in response to noxious mechanical stimulation of the peripheral receptive field was used to study the somatotopic representation of the oral mucous membrane and trigeminal cutaneous receptive fields in the trigeminal subnucleus caudalis and the cervical spinal dorsal horn. Fos-neurons (neurons with c-fos protein-like immunoreactivity) following stimulation of the cutaneous receptive field were found in laminae I and II of the first and second cervical segments of the spinal cord ipsilateral to the stimulation and exhibited a clear somatotopic segregation; i.e., the fos-neurons responding to receptive fields in the mandibular, maxillary, and ophthalmic divisions were arranged in a mediolateral sequence. On the other hand, fos-neurons responding to the oral mucous membrane were found in the similar laminae of the rostral pole of subnucleus caudalis bilaterally. They were all found in the dorsalmost part of the subnucleus without segregation; e.g., topographic distributions of fos-neurons resulting from the mandibular and maxillary gingival stimulations were indistinguishable. The central mechanism of trigeminal nociception is discussed with respect to the difference between intra- and extraoral receptive fields.

UR - http://www.scopus.com/inward/record.url?scp=0028171980&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0028171980&partnerID=8YFLogxK

U2 - 10.1006/exnr.1994.1167

DO - 10.1006/exnr.1994.1167

M3 - Article

C2 - 7957740

AN - SCOPUS:0028171980

VL - 129

SP - 251

EP - 256

JO - Experimental Neurology

JF - Experimental Neurology

SN - 0014-4886

IS - 2

ER -