c-Fos expression by dorsal horn neurons chronically deafferented by peripheral nerve section in response to spared, somatotopically inappropriate nociceptive primary input

Tomosada Sugimoto, Hiroyuki Ichikawa, Hiroyuki Hijiya, Seiji Mitani, Tadao Nakago

Research output: Contribution to journalArticle

42 Citations (Scopus)

Abstract

Subcutaneous formalin injection into the hindpaw of rats induces c-Fos expression in neurons in the ipsilateral spinal cord dorsal horn. In laminae I and II of the dorsal horn at the junction of 4th and 5th segments of the lumbar spinal cord, neurons exhibiting c-Fos protein-like immunoreactivity (Fos-LI) are concentrated in the medial 3 4 that correspond to the terminal field of primary neurons innervating the sciatic nerve. Subacute tibial nerve section 24 h before formalin stimulation caused almost complete elimination of neurons with the formalin-induced Fos-LI in the medial 1 2 (tibial territory) of the above sciatic territory of the dorsal horn. Following a longer survival period (chronic tibial nerve section of 21 days standing), neurons with the formalin-induced Fos-LI re-appeared in the tibial territory. In addition, the number of neurons with the formalin-induced Fos-LI increased in the medial part of the peroneal territory (the lateral 1 2 of the sciatic territory). The results indicate that the activation of c-Fos expression in that part of dorsal horn that has been chronically deafferented by the tibial nerve section is taken over by the spared, but somatotopically inappropriate primary nociceptors. Furthermore, dorsal horn neurons outside but near the deafferented tibial nerve's territory exhibit hypersensitivity to c-Fos expression evoked by intact, somatotopically appropriate primary nociceptive input.

Original languageEnglish
Pages (from-to)161-166
Number of pages6
JournalBrain Research
Volume621
Issue number1
DOIs
Publication statusPublished - Sep 3 1993

Fingerprint

Posterior Horn Cells
Peripheral Nerves
Tibial Nerve
Formaldehyde
Neurons
Spinal Cord
Substantia Gelatinosa
Proto-Oncogene Proteins c-fos
Nociceptors
Proteins
Sciatic Nerve
Subcutaneous Injections
Hypersensitivity
Spinal Cord Dorsal Horn

Keywords

  • c-Fos
  • Dorsal horn
  • Peripheral nerve injury
  • Peroneal nerve
  • Somatotopy
  • Tibial nerve

ASJC Scopus subject areas

  • Developmental Biology
  • Molecular Biology
  • Clinical Neurology
  • Neuroscience(all)

Cite this

c-Fos expression by dorsal horn neurons chronically deafferented by peripheral nerve section in response to spared, somatotopically inappropriate nociceptive primary input. / Sugimoto, Tomosada; Ichikawa, Hiroyuki; Hijiya, Hiroyuki; Mitani, Seiji; Nakago, Tadao.

In: Brain Research, Vol. 621, No. 1, 03.09.1993, p. 161-166.

Research output: Contribution to journalArticle

Sugimoto, Tomosada ; Ichikawa, Hiroyuki ; Hijiya, Hiroyuki ; Mitani, Seiji ; Nakago, Tadao. / c-Fos expression by dorsal horn neurons chronically deafferented by peripheral nerve section in response to spared, somatotopically inappropriate nociceptive primary input. In: Brain Research. 1993 ; Vol. 621, No. 1. pp. 161-166.
@article{c3df3c01c9264f4997f4cece9b820b5d,
title = "c-Fos expression by dorsal horn neurons chronically deafferented by peripheral nerve section in response to spared, somatotopically inappropriate nociceptive primary input",
abstract = "Subcutaneous formalin injection into the hindpaw of rats induces c-Fos expression in neurons in the ipsilateral spinal cord dorsal horn. In laminae I and II of the dorsal horn at the junction of 4th and 5th segments of the lumbar spinal cord, neurons exhibiting c-Fos protein-like immunoreactivity (Fos-LI) are concentrated in the medial 3 4 that correspond to the terminal field of primary neurons innervating the sciatic nerve. Subacute tibial nerve section 24 h before formalin stimulation caused almost complete elimination of neurons with the formalin-induced Fos-LI in the medial 1 2 (tibial territory) of the above sciatic territory of the dorsal horn. Following a longer survival period (chronic tibial nerve section of 21 days standing), neurons with the formalin-induced Fos-LI re-appeared in the tibial territory. In addition, the number of neurons with the formalin-induced Fos-LI increased in the medial part of the peroneal territory (the lateral 1 2 of the sciatic territory). The results indicate that the activation of c-Fos expression in that part of dorsal horn that has been chronically deafferented by the tibial nerve section is taken over by the spared, but somatotopically inappropriate primary nociceptors. Furthermore, dorsal horn neurons outside but near the deafferented tibial nerve's territory exhibit hypersensitivity to c-Fos expression evoked by intact, somatotopically appropriate primary nociceptive input.",
keywords = "c-Fos, Dorsal horn, Peripheral nerve injury, Peroneal nerve, Somatotopy, Tibial nerve",
author = "Tomosada Sugimoto and Hiroyuki Ichikawa and Hiroyuki Hijiya and Seiji Mitani and Tadao Nakago",
year = "1993",
month = "9",
day = "3",
doi = "10.1016/0006-8993(93)90314-D",
language = "English",
volume = "621",
pages = "161--166",
journal = "Brain Research",
issn = "0006-8993",
publisher = "Elsevier",
number = "1",

}

TY - JOUR

T1 - c-Fos expression by dorsal horn neurons chronically deafferented by peripheral nerve section in response to spared, somatotopically inappropriate nociceptive primary input

AU - Sugimoto, Tomosada

AU - Ichikawa, Hiroyuki

AU - Hijiya, Hiroyuki

AU - Mitani, Seiji

AU - Nakago, Tadao

PY - 1993/9/3

Y1 - 1993/9/3

N2 - Subcutaneous formalin injection into the hindpaw of rats induces c-Fos expression in neurons in the ipsilateral spinal cord dorsal horn. In laminae I and II of the dorsal horn at the junction of 4th and 5th segments of the lumbar spinal cord, neurons exhibiting c-Fos protein-like immunoreactivity (Fos-LI) are concentrated in the medial 3 4 that correspond to the terminal field of primary neurons innervating the sciatic nerve. Subacute tibial nerve section 24 h before formalin stimulation caused almost complete elimination of neurons with the formalin-induced Fos-LI in the medial 1 2 (tibial territory) of the above sciatic territory of the dorsal horn. Following a longer survival period (chronic tibial nerve section of 21 days standing), neurons with the formalin-induced Fos-LI re-appeared in the tibial territory. In addition, the number of neurons with the formalin-induced Fos-LI increased in the medial part of the peroneal territory (the lateral 1 2 of the sciatic territory). The results indicate that the activation of c-Fos expression in that part of dorsal horn that has been chronically deafferented by the tibial nerve section is taken over by the spared, but somatotopically inappropriate primary nociceptors. Furthermore, dorsal horn neurons outside but near the deafferented tibial nerve's territory exhibit hypersensitivity to c-Fos expression evoked by intact, somatotopically appropriate primary nociceptive input.

AB - Subcutaneous formalin injection into the hindpaw of rats induces c-Fos expression in neurons in the ipsilateral spinal cord dorsal horn. In laminae I and II of the dorsal horn at the junction of 4th and 5th segments of the lumbar spinal cord, neurons exhibiting c-Fos protein-like immunoreactivity (Fos-LI) are concentrated in the medial 3 4 that correspond to the terminal field of primary neurons innervating the sciatic nerve. Subacute tibial nerve section 24 h before formalin stimulation caused almost complete elimination of neurons with the formalin-induced Fos-LI in the medial 1 2 (tibial territory) of the above sciatic territory of the dorsal horn. Following a longer survival period (chronic tibial nerve section of 21 days standing), neurons with the formalin-induced Fos-LI re-appeared in the tibial territory. In addition, the number of neurons with the formalin-induced Fos-LI increased in the medial part of the peroneal territory (the lateral 1 2 of the sciatic territory). The results indicate that the activation of c-Fos expression in that part of dorsal horn that has been chronically deafferented by the tibial nerve section is taken over by the spared, but somatotopically inappropriate primary nociceptors. Furthermore, dorsal horn neurons outside but near the deafferented tibial nerve's territory exhibit hypersensitivity to c-Fos expression evoked by intact, somatotopically appropriate primary nociceptive input.

KW - c-Fos

KW - Dorsal horn

KW - Peripheral nerve injury

KW - Peroneal nerve

KW - Somatotopy

KW - Tibial nerve

UR - http://www.scopus.com/inward/record.url?scp=0027317847&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0027317847&partnerID=8YFLogxK

U2 - 10.1016/0006-8993(93)90314-D

DO - 10.1016/0006-8993(93)90314-D

M3 - Article

C2 - 8221069

AN - SCOPUS:0027317847

VL - 621

SP - 161

EP - 166

JO - Brain Research

JF - Brain Research

SN - 0006-8993

IS - 1

ER -