BW1003C87, phenytoin and carbamazepine elevate seizure threshold in the rat amygdala-kindling model of epilepsy

Kiyoshi Morimoto, Hitoshi Sato, Keiko Sato, Soichiro Sato, Yamada Norihito Yamada

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

We examined the anticonvulsant effects of BW1003C87 (5-(2,3,5- trichlorophenyl)-2,4-diaminopyrimidine ethane sulphonic acid), which is structurally related to the new antiepileptic drug, lamotrigine, and compared its effects to those of the conventional antiepileptic drugs, phenytoin and carbamazopine, using the rat amygdala-kindling model of epilepsy. BW1003C87 (2.5-10 mg/kg, i.p.) had potent and long-lasting (48 h after single administration) effects on amygdala-kindled seizures. The effects of BW1003C87 were completely reversed when the stimulus intensity was increased to 2 or 3 times the threshold determined. Since the same effects on seizure threshold were obtained for phenytoin and carbamazepine in the present study and for lamotrigine in our previous study, we propose that the principal mechanism of these antiepileptic drugs, which act primarily on voltage- sensitive Na+ channels, is significant elevation of the seizure threshold in epileptogenic loci and that BW1003C87 has a profile similar to that of these drugs.

Original languageEnglish
Pages (from-to)11-15
Number of pages5
JournalEuropean Journal of Pharmacology
Volume339
Issue number1
DOIs
Publication statusPublished - Nov 19 1997

Keywords

  • Amygdala- kindling
  • Anticonvulsant effects
  • BW1003C87
  • Carbamazopine
  • Phenytoin
  • Seizure threshold

ASJC Scopus subject areas

  • Pharmacology

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