Buspirone enhances immobility in the forced swim test in mice

Yoshihisa Kitamura, Tadashi Nagatani

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

We studied the effects of buspirone and 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT) on duration of immobility in mice in the forced swim test. Buspirone [3-10 mg/kg, intraperitoneally (IP)] potently and dose dependently increased the duration of immobility in mice. In contrast, following a single dose of 8-OH-DPAT (1-3 mg/kg, IP), there was a dose-dependent decrease in the duration of immobility. Pretreatment with the 5-HT synthesis inhibitor p-chlorophenylalanine (200 mg/kg, IP, 3 days before further drug treatment) did not alter the effects of buspirone or 8-OH-DPAT The increase in the duration of immobility induced by buspirone (3 mg/kg, IP) was blocked by NAN-190 [1-(2-methoxyphenyl)-4-(4-[2-phthalimido]butyl)-piperazine hydrobromide, 1 mg/kg, IP), a postsynaptic 5-HT(1A) receptor antagonist. However, the effect of 8-OH-DPAT (1 mg/kg, IP) was not blocked by NAN-190 (1 mg/kg, IP). The effect of buspirone (3 mg/kg, IP) was blocked by apomorphine (0.3 mg/kg, IP), a dopamine receptor agonist. Based on the results of this study, it is suggested that the effects of buspirone and of 8-OH-DPAT on immobility in the forced swim test may occur through different mechanisms.

Original languageEnglish
Pages (from-to)445-451
Number of pages7
JournalPharmacology Biochemistry and Behavior
Volume55
Issue number3
DOIs
Publication statusPublished - Nov 1 1996
Externally publishedYes

Keywords

  • 5-Hydroxytryptamine (5-HT)(1A) receptor
  • 8-OH-DPAT
  • Buspirone
  • Forced swim test

ASJC Scopus subject areas

  • Biochemistry
  • Toxicology
  • Pharmacology
  • Clinical Biochemistry
  • Biological Psychiatry
  • Behavioral Neuroscience

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