Buspirone enhances head twitch behavior in mice

Yoshihisa Kitamura, Tadashi Nagatani, Takami Watanabe

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

We studied the effects of buspirone, a 5-HT1A receptor agonist, on head twitch behavior induced by 5-hydroxy-l-tryptophan (5-HTP) administered together with pargyline in mice. Buspirone dose dependently (0.1 - 10 mg/kg i.p.) enhanced head twitch behavior. This effect was blocked by (-)-propranolol and NAN-190 (1-(2-methoxyphenyl)-4-[4-(2-phthalimido)butyl]-piperazine hydrobromide). The enhancing effect of buspirone was also observed when mice were pretreated with p-chlorophenylalanine. These findings suggest that the enhancing effect of buspirone on head twitch behavior may be extended through the activation of post-synaptic 5-HT1A receptors.

Original languageEnglish
Pages (from-to)297-301
Number of pages5
JournalEuropean Journal of Pharmacology
Volume253
Issue number3
DOIs
Publication statusPublished - Mar 3 1994
Externally publishedYes

Keywords

  • (8-hydroxy-2-(di-n-propylamino)tetralin)
  • (Mouse)
  • 5-HT receptor
  • 5-HT receptors
  • 8-OH-DPAT
  • Buspirone
  • Head twitch behavior

ASJC Scopus subject areas

  • Pharmacology

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