Burned-out prostate cancer? Primary metastatic cancer not detected on repeat biopsy

Yosuke Mitsui, Takuya Sadahira, Yuki Maruyama, Koichiro Wada, Ryuta Tanimoto, Morito Sugimoto, Motoo Araki, Masami Watanabe, Hiroyuki Yanai, Toyohiko Watanabe, Yasutomo Nasu

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)


Metastatic prostate cancer (PCa) cases that cannot be detected on repeat prostate biopsy are extremely rare. Our patient was a 51-year-old Japanese man diagnosed as metastatic PCa by histopathological examination of lesions obtained bone biopsy and lymph node dissection. The primary tumor was not detected after repeated prostate biopsy. Metastatic PCa was diagnosed based on immunohistochemical staining: PSA, AR, P504S, and NKX3.1 of bone and lymph node with metastasis. We speculate that the primary PCa was "burned-out," demonstrating remote metastases with no apparent primary tumor in the prostate. Burned-out PCa may be difficult to diagnose and treat due to its rarity.

Original languageEnglish
Pages (from-to)605-609
Number of pages5
JournalActa medica Okayama
Issue number6
Publication statusPublished - 2018


  • CRPC
  • Metastasis
  • Prostate cancer
  • Repeat biopsy
  • Unknown primary tumor

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)


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