Burned-out prostate cancer? Primary metastatic cancer not detected on repeat biopsy

Yosuke Mitsui; Takuya Sadahira; Yuki Maruyama; Koichiro Wada; Ryuta Tanimoto; Morito Sugimoto; Motoo Araki; Masami Watanabe; Hiroyuki Yanai; Toyohiko Watanabe; Yasutomo Nasu

Burned-out prostate cancer? Primary metastatic cancer not detected on repeat biopsy

Yosuke Mitsui, Takuya Sadahira, Yuki Maruyama, Koichiro Wada, Ryuta Tanimoto, Morito Sugimoto, Motoo Araki, Masami Watanabe, Hiroyuki Yanai, Toyohiko Watanabe, Yasutomo Nasu

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Abstract

Metastatic prostate cancer (PCa) cases that cannot be detected on repeat prostate biopsy are extremely rare. Our patient was a 51-year-old Japanese man diagnosed as metastatic PCa by histopathological examination of lesions obtained bone biopsy and lymph node dissection. The primary tumor was not detected after repeated prostate biopsy. Metastatic PCa was diagnosed based on immunohistochemical staining: PSA, AR, P504S, and NKX3.1 of bone and lymph node with metastasis. We speculate that the primary PCa was "burned-out," demonstrating remote metastases with no apparent primary tumor in the prostate. Burned-out PCa may be difficult to diagnose and treat due to its rarity.

Original language	English
Pages (from-to)	605-609
Number of pages	5
Journal	Acta medica Okayama
Volume	72
Issue number	6
Publication status	Published - 2018

Keywords

CRPC
Metastasis
Prostate cancer
Repeat biopsy
Unknown primary tumor

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Cite this

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abstract = "Metastatic prostate cancer (PCa) cases that cannot be detected on repeat prostate biopsy are extremely rare. Our patient was a 51-year-old Japanese man diagnosed as metastatic PCa by histopathological examination of lesions obtained bone biopsy and lymph node dissection. The primary tumor was not detected after repeated prostate biopsy. Metastatic PCa was diagnosed based on immunohistochemical staining: PSA, AR, P504S, and NKX3.1 of bone and lymph node with metastasis. We speculate that the primary PCa was {"}burned-out,{"} demonstrating remote metastases with no apparent primary tumor in the prostate. Burned-out PCa may be difficult to diagnose and treat due to its rarity.",

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T1 - Burned-out prostate cancer? Primary metastatic cancer not detected on repeat biopsy

AU - Mitsui, Yosuke

AU - Sadahira, Takuya

AU - Maruyama, Yuki

AU - Wada, Koichiro

AU - Tanimoto, Ryuta

AU - Sugimoto, Morito

AU - Araki, Motoo

AU - Watanabe, Masami

AU - Yanai, Hiroyuki

AU - Watanabe, Toyohiko

AU - Nasu, Yasutomo

PY - 2018

Y1 - 2018

N2 - Metastatic prostate cancer (PCa) cases that cannot be detected on repeat prostate biopsy are extremely rare. Our patient was a 51-year-old Japanese man diagnosed as metastatic PCa by histopathological examination of lesions obtained bone biopsy and lymph node dissection. The primary tumor was not detected after repeated prostate biopsy. Metastatic PCa was diagnosed based on immunohistochemical staining: PSA, AR, P504S, and NKX3.1 of bone and lymph node with metastasis. We speculate that the primary PCa was "burned-out," demonstrating remote metastases with no apparent primary tumor in the prostate. Burned-out PCa may be difficult to diagnose and treat due to its rarity.

AB - Metastatic prostate cancer (PCa) cases that cannot be detected on repeat prostate biopsy are extremely rare. Our patient was a 51-year-old Japanese man diagnosed as metastatic PCa by histopathological examination of lesions obtained bone biopsy and lymph node dissection. The primary tumor was not detected after repeated prostate biopsy. Metastatic PCa was diagnosed based on immunohistochemical staining: PSA, AR, P504S, and NKX3.1 of bone and lymph node with metastasis. We speculate that the primary PCa was "burned-out," demonstrating remote metastases with no apparent primary tumor in the prostate. Burned-out PCa may be difficult to diagnose and treat due to its rarity.

KW - CRPC

KW - Metastasis

KW - Prostate cancer

KW - Repeat biopsy

KW - Unknown primary tumor

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Burned-out prostate cancer? Primary metastatic cancer not detected on repeat biopsy

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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