Buchwald–Hartwig Amination of Nitroarenes

Fumiyoshi Inoue, Myuto Kashihara, M. Ramu Yadav, Yoshiaki Nakao

Research output: Contribution to journalArticlepeer-review

66 Citations (Scopus)

Abstract

The Buchwald–Hartwig amination of nitroarenes was achieved for the first time by using palladium catalysts bearing dialkyl(biaryl)phosphine ligands. These cross-coupling reactions of nitroarenes with diarylamines, arylamines, and alkylamines afforded the corresponding substituted arylamines. A catalytic cycle involving the oxidative addition of the Ar−NO2 bond to palladium(0) followed by nitrite/amine exchange is proposed based on a stoichiometric reaction.

Original languageEnglish
Pages (from-to)13307-13309
Number of pages3
JournalAngewandte Chemie - International Edition
Volume56
Issue number43
DOIs
Publication statusPublished - Oct 16 2017
Externally publishedYes

Keywords

  • amination
  • cross-coupling
  • C−N activation
  • nitroarenes
  • palladium

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)

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