Bromocriptine protects mice against 6-hydroxydopamine and scavenges hydroxyl free radicals in vitro

Norio Ogawa, Ken ichi Tanaka, Masato Asanuma, Motoko Kawai, Toshiki Masumizu, Masahiro Kohno, Akitane Mori

Research output: Contribution to journalArticle

155 Citations (Scopus)

Abstract

Pretreatment with bromocriptine (5 mg/kg, i.p., 7 days) completely protected against the decrease in mouse striatal dopamine and its metabolites induced by intraventricular injection of 6-hydroxydopamine after intraperitoneal administration of desipramine, but similar pretreatment with l-DOPA/carbidopa (75/7.5 mg/kg, i.p., 7 days) showed only partial protective effect. Furthermore, in an in vitro system that generated ·OH from FeSO4-H2O2, bromocriptine dose-dependently reduced the number of ·OH radicals. These findings indicate that bromocriptine has a neuroprotective effect against neurotoxins such as 6-hydroxydopamine, probably due, in part, to its hydroxyl radical scavenging activity and inhibiting effect on dopamine turnover rate. This suggests that early introduction of bromocriptine in the therapy of Parkinson's disease may be superior to treatment with l-DOPA alone.

Original languageEnglish
Pages (from-to)207-213
Number of pages7
JournalBrain Research
Volume657
Issue number1-2
DOIs
Publication statusPublished - Sep 19 1994

Keywords

  • 6-Hydroxydopamine
  • Bromocriptine
  • Free radical
  • Hydroxyl radical
  • Neuroprotection
  • Parkinson's disease
  • l-DOPA

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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