Brn-3a deficiency increases tyrosine hydroxylase-immunoreactive neurons in the dorsal root ganglion

Hiroyuki Ichikawa, Zeqian Mo, Mengqing Xiang, Tomosada Sugimoto

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Immunohistochemistry for tyrosine hydroxylase (TH) was performed on the dorsal root ganglia (DRG) in wild-type, heterozygous and Brn-3a knockout mice at embryonic day 18.5. TH-immunoreactive (-IR) neurons were detected in the DRG of wild-type and heterozygous mice, but their proportion was greatly increased by the loss of Brn-3a function (wild-type and heterozygot, 8.4%; knockout, 20.9%). IR neurons were of various sizes in wild-type (mean ± S.D. = 118.1 ± 55.4 μm2, range = 26.6-306.3 μm2) and heterozygous mice. In the knockout mice, however, TH-IR neurons were mostly small (mean ± S.D. = 68.2 ± 34.3 μm2, range = 11.8-166.8 μm2). The present study suggests that Brn-3a may normally suppress TH expression in many small DRG neurons but activate TH expression in large DRG neurons.

Original languageEnglish
Pages (from-to)192-195
Number of pages4
JournalBrain Research
Volume1036
Issue number1-2
DOIs
Publication statusPublished - Mar 2 2005

Keywords

  • Brn-3a
  • Calcitonin gene-related peptide
  • Dorsal root ganglion
  • Immunohistochemistry
  • Knockout mouse
  • Tyrosine hydroxylase

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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