Breast cancer with cartilaginous and/or osseous metaplasia diagnosed by lymph nodal metastasis: A case report

Kazunori Tsukuda, Hisashi Tsujia, Tadayoshi Kunitomo, Keiju Aokage, Takayoshi Miyake, Saki Nakahara, Hiroko Masuda

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Breast cancer with cartilaginous and/or osseous metaplasia is a type of metaplastic carcinomas and is a rare disease. We report the case of a 49 year-old female who underwent right mastectomy for a large breast tumor. Histological examinations revealed a mixed tumor with both stromal and epithelial elements; the stroma showed poor differentiated spindle-shape and multiform cells with a massive osseous matrix, and atypical epithelial cells, which mainly existed on the surface of the cysts, showed nucleic atypia. The tumor was diagnosed as a malignant phyllodes tumor with osteosarcomatous differentiation; it was not identified as a metaplastic carcinoma because of the lack of proof of a cancerous component. Two years after a mastectomy, swelling of the axillary lymph nodes was found and a biopsy was performed. Histological findings for the lymph node indicated a metastasis of the invasive ductal carcinoma. The primary tumor was re-examined and was considered to be the origin of the lymph nodal metastasis. Lymph nodal metastasis of cancer proved that the primary tumor had cancerous potential, and the pathological diagnosis was altered to a breast cancer with cartilaginous and/or osseous metaplasia.

Original languageEnglish
Pages (from-to)367-371
Number of pages5
JournalActa Medica Okayama
Volume63
Issue number6
Publication statusPublished - Dec 2009

Fingerprint

Metaplasia
Lymph
Tumors
Breast Neoplasms
Neoplasm Metastasis
Mastectomy
Neoplasms
Lymph Nodes
Phyllodes Tumor
Carcinoma
Ductal Carcinoma
Cell Shape
Rare Diseases
Biopsy
Cysts
Epithelial Cells
Swelling

Keywords

  • Breast cancer
  • Metaplastic cancer
  • Phyllodes tumor

ASJC Scopus subject areas

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Tsukuda, K., Tsujia, H., Kunitomo, T., Aokage, K., Miyake, T., Nakahara, S., & Masuda, H. (2009). Breast cancer with cartilaginous and/or osseous metaplasia diagnosed by lymph nodal metastasis: A case report. Acta Medica Okayama, 63(6), 367-371.

Breast cancer with cartilaginous and/or osseous metaplasia diagnosed by lymph nodal metastasis : A case report. / Tsukuda, Kazunori; Tsujia, Hisashi; Kunitomo, Tadayoshi; Aokage, Keiju; Miyake, Takayoshi; Nakahara, Saki; Masuda, Hiroko.

In: Acta Medica Okayama, Vol. 63, No. 6, 12.2009, p. 367-371.

Research output: Contribution to journalArticle

Tsukuda, K, Tsujia, H, Kunitomo, T, Aokage, K, Miyake, T, Nakahara, S & Masuda, H 2009, 'Breast cancer with cartilaginous and/or osseous metaplasia diagnosed by lymph nodal metastasis: A case report', Acta Medica Okayama, vol. 63, no. 6, pp. 367-371.
Tsukuda K, Tsujia H, Kunitomo T, Aokage K, Miyake T, Nakahara S et al. Breast cancer with cartilaginous and/or osseous metaplasia diagnosed by lymph nodal metastasis: A case report. Acta Medica Okayama. 2009 Dec;63(6):367-371.
Tsukuda, Kazunori ; Tsujia, Hisashi ; Kunitomo, Tadayoshi ; Aokage, Keiju ; Miyake, Takayoshi ; Nakahara, Saki ; Masuda, Hiroko. / Breast cancer with cartilaginous and/or osseous metaplasia diagnosed by lymph nodal metastasis : A case report. In: Acta Medica Okayama. 2009 ; Vol. 63, No. 6. pp. 367-371.
@article{e4a7a4dbfdcd4172b62d890ecae4bd01,
title = "Breast cancer with cartilaginous and/or osseous metaplasia diagnosed by lymph nodal metastasis: A case report",
abstract = "Breast cancer with cartilaginous and/or osseous metaplasia is a type of metaplastic carcinomas and is a rare disease. We report the case of a 49 year-old female who underwent right mastectomy for a large breast tumor. Histological examinations revealed a mixed tumor with both stromal and epithelial elements; the stroma showed poor differentiated spindle-shape and multiform cells with a massive osseous matrix, and atypical epithelial cells, which mainly existed on the surface of the cysts, showed nucleic atypia. The tumor was diagnosed as a malignant phyllodes tumor with osteosarcomatous differentiation; it was not identified as a metaplastic carcinoma because of the lack of proof of a cancerous component. Two years after a mastectomy, swelling of the axillary lymph nodes was found and a biopsy was performed. Histological findings for the lymph node indicated a metastasis of the invasive ductal carcinoma. The primary tumor was re-examined and was considered to be the origin of the lymph nodal metastasis. Lymph nodal metastasis of cancer proved that the primary tumor had cancerous potential, and the pathological diagnosis was altered to a breast cancer with cartilaginous and/or osseous metaplasia.",
keywords = "Breast cancer, Metaplastic cancer, Phyllodes tumor",
author = "Kazunori Tsukuda and Hisashi Tsujia and Tadayoshi Kunitomo and Keiju Aokage and Takayoshi Miyake and Saki Nakahara and Hiroko Masuda",
year = "2009",
month = "12",
language = "English",
volume = "63",
pages = "367--371",
journal = "Acta Medica Okayama",
issn = "0386-300X",
publisher = "Okayama University",
number = "6",

}

TY - JOUR

T1 - Breast cancer with cartilaginous and/or osseous metaplasia diagnosed by lymph nodal metastasis

T2 - A case report

AU - Tsukuda, Kazunori

AU - Tsujia, Hisashi

AU - Kunitomo, Tadayoshi

AU - Aokage, Keiju

AU - Miyake, Takayoshi

AU - Nakahara, Saki

AU - Masuda, Hiroko

PY - 2009/12

Y1 - 2009/12

N2 - Breast cancer with cartilaginous and/or osseous metaplasia is a type of metaplastic carcinomas and is a rare disease. We report the case of a 49 year-old female who underwent right mastectomy for a large breast tumor. Histological examinations revealed a mixed tumor with both stromal and epithelial elements; the stroma showed poor differentiated spindle-shape and multiform cells with a massive osseous matrix, and atypical epithelial cells, which mainly existed on the surface of the cysts, showed nucleic atypia. The tumor was diagnosed as a malignant phyllodes tumor with osteosarcomatous differentiation; it was not identified as a metaplastic carcinoma because of the lack of proof of a cancerous component. Two years after a mastectomy, swelling of the axillary lymph nodes was found and a biopsy was performed. Histological findings for the lymph node indicated a metastasis of the invasive ductal carcinoma. The primary tumor was re-examined and was considered to be the origin of the lymph nodal metastasis. Lymph nodal metastasis of cancer proved that the primary tumor had cancerous potential, and the pathological diagnosis was altered to a breast cancer with cartilaginous and/or osseous metaplasia.

AB - Breast cancer with cartilaginous and/or osseous metaplasia is a type of metaplastic carcinomas and is a rare disease. We report the case of a 49 year-old female who underwent right mastectomy for a large breast tumor. Histological examinations revealed a mixed tumor with both stromal and epithelial elements; the stroma showed poor differentiated spindle-shape and multiform cells with a massive osseous matrix, and atypical epithelial cells, which mainly existed on the surface of the cysts, showed nucleic atypia. The tumor was diagnosed as a malignant phyllodes tumor with osteosarcomatous differentiation; it was not identified as a metaplastic carcinoma because of the lack of proof of a cancerous component. Two years after a mastectomy, swelling of the axillary lymph nodes was found and a biopsy was performed. Histological findings for the lymph node indicated a metastasis of the invasive ductal carcinoma. The primary tumor was re-examined and was considered to be the origin of the lymph nodal metastasis. Lymph nodal metastasis of cancer proved that the primary tumor had cancerous potential, and the pathological diagnosis was altered to a breast cancer with cartilaginous and/or osseous metaplasia.

KW - Breast cancer

KW - Metaplastic cancer

KW - Phyllodes tumor

UR - http://www.scopus.com/inward/record.url?scp=74349093683&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=74349093683&partnerID=8YFLogxK

M3 - Article

C2 - 20035293

AN - SCOPUS:74349093683

VL - 63

SP - 367

EP - 371

JO - Acta Medica Okayama

JF - Acta Medica Okayama

SN - 0386-300X

IS - 6

ER -