Breast cancer subtype and distant recurrence after ipsilateral breast tumor recurrence

Makoto Ishitobi, Yasuhiro Okumura, Nobuyuki Arima, Atsushi Yoshida, Katsuhiko Nakatsukasa, Takuji Iwase, Tadahiko Shien, Norikazu Masuda, Satoru Tanaka, Masahiko Tanabe, Takehiro Tanaka, Yoshifumi Komoike, Tetsuya Taguchi, Reiki Nishimura, Hideo Inaji

Research output: Contribution to journalArticle

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Abstract

Background: There is little information about the impact of breast cancer subtype on prognosis after ipsilateral breast tumor recurrence (IBTR). Methods: One hundred eighty-five patients were classified according to breast cancer subtype, as approximated by estrogen receptor, human epidermal growth factor receptor 2 (HER2), and Ki-67, of IBTR, and we evaluated whether breast cancer subtype was associated with distant recurrence after IBTR. Results: There was a significant difference in distant disease-free survival (DDFS) after IBTR according to breast cancer subtype defined by a cutoff of the Ki-67 index of 20 % (p = 0.0074, log-rank test). The 5-year DDFS rates for patients with luminal A, luminal B, triple-negative, and HER2 types were 86.3, 57.1, 56.6, and 65.9 %, respectively. In addition, breast cancer subtype was significantly associated with distant recurrence after IBTR on adjustment for various clinicopathologic factors (p = 0.0027, Cox proportional hazards model). Conclusions: Our study suggests that breast cancer subtype based on immunohistochemical staining predicts the outcomes of patients with IBTR. Further analyses are needed (UMIN-CTR number UMIN000008136).

Original languageEnglish
Pages (from-to)1886-1892
Number of pages7
JournalAnnals of Surgical Oncology
Volume20
Issue number6
DOIs
Publication statusPublished - Jun 2013

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Breast Neoplasms
Recurrence
Disease-Free Survival
Proportional Hazards Models
Estrogen Receptors
Survival Rate
Staining and Labeling

ASJC Scopus subject areas

  • Surgery
  • Oncology

Cite this

Ishitobi, M., Okumura, Y., Arima, N., Yoshida, A., Nakatsukasa, K., Iwase, T., ... Inaji, H. (2013). Breast cancer subtype and distant recurrence after ipsilateral breast tumor recurrence. Annals of Surgical Oncology, 20(6), 1886-1892. https://doi.org/10.1245/s10434-012-2825-1

Breast cancer subtype and distant recurrence after ipsilateral breast tumor recurrence. / Ishitobi, Makoto; Okumura, Yasuhiro; Arima, Nobuyuki; Yoshida, Atsushi; Nakatsukasa, Katsuhiko; Iwase, Takuji; Shien, Tadahiko; Masuda, Norikazu; Tanaka, Satoru; Tanabe, Masahiko; Tanaka, Takehiro; Komoike, Yoshifumi; Taguchi, Tetsuya; Nishimura, Reiki; Inaji, Hideo.

In: Annals of Surgical Oncology, Vol. 20, No. 6, 06.2013, p. 1886-1892.

Research output: Contribution to journalArticle

Ishitobi, M, Okumura, Y, Arima, N, Yoshida, A, Nakatsukasa, K, Iwase, T, Shien, T, Masuda, N, Tanaka, S, Tanabe, M, Tanaka, T, Komoike, Y, Taguchi, T, Nishimura, R & Inaji, H 2013, 'Breast cancer subtype and distant recurrence after ipsilateral breast tumor recurrence', Annals of Surgical Oncology, vol. 20, no. 6, pp. 1886-1892. https://doi.org/10.1245/s10434-012-2825-1
Ishitobi M, Okumura Y, Arima N, Yoshida A, Nakatsukasa K, Iwase T et al. Breast cancer subtype and distant recurrence after ipsilateral breast tumor recurrence. Annals of Surgical Oncology. 2013 Jun;20(6):1886-1892. https://doi.org/10.1245/s10434-012-2825-1
Ishitobi, Makoto ; Okumura, Yasuhiro ; Arima, Nobuyuki ; Yoshida, Atsushi ; Nakatsukasa, Katsuhiko ; Iwase, Takuji ; Shien, Tadahiko ; Masuda, Norikazu ; Tanaka, Satoru ; Tanabe, Masahiko ; Tanaka, Takehiro ; Komoike, Yoshifumi ; Taguchi, Tetsuya ; Nishimura, Reiki ; Inaji, Hideo. / Breast cancer subtype and distant recurrence after ipsilateral breast tumor recurrence. In: Annals of Surgical Oncology. 2013 ; Vol. 20, No. 6. pp. 1886-1892.
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AU - Iwase, Takuji

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AU - Tanaka, Takehiro

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N2 - Background: There is little information about the impact of breast cancer subtype on prognosis after ipsilateral breast tumor recurrence (IBTR). Methods: One hundred eighty-five patients were classified according to breast cancer subtype, as approximated by estrogen receptor, human epidermal growth factor receptor 2 (HER2), and Ki-67, of IBTR, and we evaluated whether breast cancer subtype was associated with distant recurrence after IBTR. Results: There was a significant difference in distant disease-free survival (DDFS) after IBTR according to breast cancer subtype defined by a cutoff of the Ki-67 index of 20 % (p = 0.0074, log-rank test). The 5-year DDFS rates for patients with luminal A, luminal B, triple-negative, and HER2 types were 86.3, 57.1, 56.6, and 65.9 %, respectively. In addition, breast cancer subtype was significantly associated with distant recurrence after IBTR on adjustment for various clinicopathologic factors (p = 0.0027, Cox proportional hazards model). Conclusions: Our study suggests that breast cancer subtype based on immunohistochemical staining predicts the outcomes of patients with IBTR. Further analyses are needed (UMIN-CTR number UMIN000008136).

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