TY - JOUR
T1 - Brainstem-type Lewy body disease presenting with progressive autonomic failure and lethargy
AU - Hishikawa, Nozomi
AU - Hashizume, Yoshio
AU - Hirayama, Masaaki
AU - Imamura, Kazuhiro
AU - Washimi, Yukihiko
AU - Koike, Yasuo
AU - Mabuchi, Chiyuki
AU - Yoshida, Mari
AU - Sobue, Gen
N1 - Funding Information:
This work was partly supported by grants from the Ministry of Welfare and Health of Japan.
PY - 2000
Y1 - 2000
N2 - The authors report an autopsy case characterized by progressive lethargy and autonomic failure with a distinctive pattern of occurrence of Lewy bodies. Autonomic dysfunction such as sleep apnea, orthostatic hypotension, dysuria, and hypohidrosis predominated with lethargy, whereas parkinsonism was not apparent. Numerous Lewy bodies were widely evident microscopically in brainstem nuclei and the intermediolateral cell columns of the spinal cord, as well as in the sympathetic ganglia, but were rare or absent in the cerebral cortex and other supratentorial structures. Marked neuronal loss was seen in the locus ceruleus, raphe nuclei, dorsal vagal nuclei, and intermediolateral cell columns, but neurons in the substantia nigra, other brain regions, and sympathetic ganglia appeared undiminished. This case represents a specific clinicopathologic form of Lewy body disease occurring predominantly in the brainstem, spinal cord, and sympathetic ganglia.
AB - The authors report an autopsy case characterized by progressive lethargy and autonomic failure with a distinctive pattern of occurrence of Lewy bodies. Autonomic dysfunction such as sleep apnea, orthostatic hypotension, dysuria, and hypohidrosis predominated with lethargy, whereas parkinsonism was not apparent. Numerous Lewy bodies were widely evident microscopically in brainstem nuclei and the intermediolateral cell columns of the spinal cord, as well as in the sympathetic ganglia, but were rare or absent in the cerebral cortex and other supratentorial structures. Marked neuronal loss was seen in the locus ceruleus, raphe nuclei, dorsal vagal nuclei, and intermediolateral cell columns, but neurons in the substantia nigra, other brain regions, and sympathetic ganglia appeared undiminished. This case represents a specific clinicopathologic form of Lewy body disease occurring predominantly in the brainstem, spinal cord, and sympathetic ganglia.
KW - Lethargy
KW - Lewy body
KW - Parkinson disease
KW - Progressive autonomic failure
KW - Sleep apnea
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U2 - 10.1007/BF02278018
DO - 10.1007/BF02278018
M3 - Article
C2 - 10954072
AN - SCOPUS:0034465228
VL - 10
SP - 139
EP - 143
JO - Clinical Autonomic Research
JF - Clinical Autonomic Research
SN - 0959-9851
IS - 3
ER -