Abstract
The authors report an autopsy case characterized by progressive lethargy and autonomic failure with a distinctive pattern of occurrence of Lewy bodies. Autonomic dysfunction such as sleep apnea, orthostatic hypotension, dysuria, and hypohidrosis predominated with lethargy, whereas parkinsonism was not apparent. Numerous Lewy bodies were widely evident microscopically in brainstem nuclei and the intermediolateral cell columns of the spinal cord, as well as in the sympathetic ganglia, but were rare or absent in the cerebral cortex and other supratentorial structures. Marked neuronal loss was seen in the locus ceruleus, raphe nuclei, dorsal vagal nuclei, and intermediolateral cell columns, but neurons in the substantia nigra, other brain regions, and sympathetic ganglia appeared undiminished. This case represents a specific clinicopathologic form of Lewy body disease occurring predominantly in the brainstem, spinal cord, and sympathetic ganglia.
| Original language | English |
|---|---|
| Pages (from-to) | 139-143 |
| Number of pages | 5 |
| Journal | Clinical Autonomic Research |
| Volume | 10 |
| Issue number | 3 |
| Publication status | Published - 2000 |
| Externally published | Yes |
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Keywords
- Lethargy
- Lewy body
- Parkinson disease
- Progressive autonomic failure
- Sleep apnea
ASJC Scopus subject areas
- Clinical Neurology
- Neuroscience(all)
Cite this
Brainstem-type Lewy body disease presenting with progressive autonomic failure and lethargy. / Hishikawa, Nozomi; Hashizume, Y.; Hirayama, M.; Imamura, K.; Washimi, Y.; Koike, Y.; Mabuchi, C.; Yoshida, M.; Sobue, G.
In: Clinical Autonomic Research, Vol. 10, No. 3, 2000, p. 139-143.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Brainstem-type Lewy body disease presenting with progressive autonomic failure and lethargy
AU - Hishikawa, Nozomi
AU - Hashizume, Y.
AU - Hirayama, M.
AU - Imamura, K.
AU - Washimi, Y.
AU - Koike, Y.
AU - Mabuchi, C.
AU - Yoshida, M.
AU - Sobue, G.
PY - 2000
Y1 - 2000
N2 - The authors report an autopsy case characterized by progressive lethargy and autonomic failure with a distinctive pattern of occurrence of Lewy bodies. Autonomic dysfunction such as sleep apnea, orthostatic hypotension, dysuria, and hypohidrosis predominated with lethargy, whereas parkinsonism was not apparent. Numerous Lewy bodies were widely evident microscopically in brainstem nuclei and the intermediolateral cell columns of the spinal cord, as well as in the sympathetic ganglia, but were rare or absent in the cerebral cortex and other supratentorial structures. Marked neuronal loss was seen in the locus ceruleus, raphe nuclei, dorsal vagal nuclei, and intermediolateral cell columns, but neurons in the substantia nigra, other brain regions, and sympathetic ganglia appeared undiminished. This case represents a specific clinicopathologic form of Lewy body disease occurring predominantly in the brainstem, spinal cord, and sympathetic ganglia.
AB - The authors report an autopsy case characterized by progressive lethargy and autonomic failure with a distinctive pattern of occurrence of Lewy bodies. Autonomic dysfunction such as sleep apnea, orthostatic hypotension, dysuria, and hypohidrosis predominated with lethargy, whereas parkinsonism was not apparent. Numerous Lewy bodies were widely evident microscopically in brainstem nuclei and the intermediolateral cell columns of the spinal cord, as well as in the sympathetic ganglia, but were rare or absent in the cerebral cortex and other supratentorial structures. Marked neuronal loss was seen in the locus ceruleus, raphe nuclei, dorsal vagal nuclei, and intermediolateral cell columns, but neurons in the substantia nigra, other brain regions, and sympathetic ganglia appeared undiminished. This case represents a specific clinicopathologic form of Lewy body disease occurring predominantly in the brainstem, spinal cord, and sympathetic ganglia.
KW - Lethargy
KW - Lewy body
KW - Parkinson disease
KW - Progressive autonomic failure
KW - Sleep apnea
UR - http://www.scopus.com/inward/record.url?scp=0034465228&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0034465228&partnerID=8YFLogxK
M3 - Article
C2 - 10954072
AN - SCOPUS:0034465228
VL - 10
SP - 139
EP - 143
JO - Clinical Autonomic Research
JF - Clinical Autonomic Research
SN - 0959-9851
IS - 3
ER -