TY - JOUR
T1 - Brain-spinal cord neural circuits controlling male sexual function and behavior
AU - Sakamoto, Hirotaka
N1 - Funding Information:
The author is grateful to Dr. Mitsuhiro Kawata, Dr. Ken-Ichi Matsuda, Dr. Etsuko Wada, Dr. Keiji Wada, Dr. Tatsuo Arii, Dr. Damian G. Zuloaga, Dr. Cynthia L. Jordan and Dr. S. Marc Breedlove for their valuable discussions and collaborations. This work was supported by KAKENHI ; Grants-in-Aid for Young Scientists (A): No. 21680031 , Grants-in-Aid for Young Scientists (B): No. 19700319 and Grants-in-Aid for Challenging Exploratory Research: No. 23659758 from the Ministry of Education, Science, Sports, Culture and Technology (MEXT), Japan ; the Uehara Memorial Foundation, Japan ; the Inamori Foundation, Japan ; the Narishige Neuroscience Research Foundation, Japan ; the Takeda Science Foundation, Japan ; the Sumitomo Foundation, Japan ; the Kanae Foundation for the Promotion of Medical Science, Japan ; the Nakajima Foundation, Japan ; the Brain Science Foundation, Japan ; and the Co-operative Study by High-voltage Electron Microscopy (H-1250M) of the National Institute for Physiological Sciences, Okazaki, Japan .
PY - 2012/2
Y1 - 2012/2
N2 - Men and women exhibit differences in sexual behavior. This indicates that neural circuits within the central nervous system (CNS) that control sexual behavior differ between the sexes, although differences in behavior are also influenced by sociocultural and hormonal factors. Sexual differentiation of the body and brain occurs during the embryonic and neonatal periods in humans and persists into adulthood with relatively low plasticity. Male sexual behavior is complex and depends on intrinsic and extrinsic factors, including olfactory, somatosensory and visceral cues. Many advances in our understanding of sexually dimorphic neural circuits have been achieved in animal models, but major issues are yet to be resolved. This review summarizes the sexually dimorphic nuclei controlling male sexual function in the rodent CNS and focuses on the interactions of the brain-spinal cord neural networks controlling male sexual behavior. Possible factors that relate findings from animal studies to human behavior are also discussed.
AB - Men and women exhibit differences in sexual behavior. This indicates that neural circuits within the central nervous system (CNS) that control sexual behavior differ between the sexes, although differences in behavior are also influenced by sociocultural and hormonal factors. Sexual differentiation of the body and brain occurs during the embryonic and neonatal periods in humans and persists into adulthood with relatively low plasticity. Male sexual behavior is complex and depends on intrinsic and extrinsic factors, including olfactory, somatosensory and visceral cues. Many advances in our understanding of sexually dimorphic neural circuits have been achieved in animal models, but major issues are yet to be resolved. This review summarizes the sexually dimorphic nuclei controlling male sexual function in the rodent CNS and focuses on the interactions of the brain-spinal cord neural networks controlling male sexual behavior. Possible factors that relate findings from animal studies to human behavior are also discussed.
KW - Brain-spinal cord neural circuits
KW - Male sexual behavior
KW - Neuroanatomy
KW - Sex steroids
KW - Sexual dimorphism
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U2 - 10.1016/j.neures.2011.11.002
DO - 10.1016/j.neures.2011.11.002
M3 - Review article
C2 - 22101370
AN - SCOPUS:84855355885
VL - 72
SP - 103
EP - 116
JO - Neuroscience Research
JF - Neuroscience Research
SN - 0168-0102
IS - 2
ER -