Brain link proteins: New insights for hyaluronan-binding proteoglycans in brain

Toshitaka Oohashi, Yoshifumi Ninomiya

Research output: Contribution to journalArticle

Abstract

Link protein is originally characterized as an abundant extracellular matrix protein in cartilage and named Crt11. It can stabilize aggregates of aggrecan and hyaluronan, giving cartilage its tensile strength. Similarly to the cartilage matrix, a high content of hyaluronan matrix has also been recognized in the brain matrix. Subsequently, several hyaluronan binding chondroitin sulphate proteoglycans, called lecticans, have been identified as the abundant extracellular matrix molecules in the developing and/or adult brain. Other than Crt11, brain-specific link protein gene, Bra11, was cloned recently. The two link proteins (LPs), old and new, are differentially expressed and seemed to be coordinately expressed with lecticans in the brain. In this review, we will focus on these brain link proteins that may play crucial roles in hyaluronan matrix.

Original languageEnglish
Pages (from-to)25-30
Number of pages6
JournalConnective Tissue
Volume35
Issue number1
Publication statusPublished - Mar 2003

Fingerprint

Proteoglycans
Hyaluronic Acid
Brain
Cartilage
Chondroitin Sulfate Proteoglycans
Aggrecans
Tensile Strength
Extracellular Matrix Proteins
Extracellular Matrix
link protein
Genes

Keywords

  • Brain
  • Hyaluronan
  • Lectican/hyalectan
  • Link protein
  • Nodes of Ranvier
  • Proteoglycan

ASJC Scopus subject areas

  • Rheumatology

Cite this

Brain link proteins : New insights for hyaluronan-binding proteoglycans in brain. / Oohashi, Toshitaka; Ninomiya, Yoshifumi.

In: Connective Tissue, Vol. 35, No. 1, 03.2003, p. 25-30.

Research output: Contribution to journalArticle

@article{bea5bd8fd8c741b99eed689dc7e8de5f,
title = "Brain link proteins: New insights for hyaluronan-binding proteoglycans in brain",
abstract = "Link protein is originally characterized as an abundant extracellular matrix protein in cartilage and named Crt11. It can stabilize aggregates of aggrecan and hyaluronan, giving cartilage its tensile strength. Similarly to the cartilage matrix, a high content of hyaluronan matrix has also been recognized in the brain matrix. Subsequently, several hyaluronan binding chondroitin sulphate proteoglycans, called lecticans, have been identified as the abundant extracellular matrix molecules in the developing and/or adult brain. Other than Crt11, brain-specific link protein gene, Bra11, was cloned recently. The two link proteins (LPs), old and new, are differentially expressed and seemed to be coordinately expressed with lecticans in the brain. In this review, we will focus on these brain link proteins that may play crucial roles in hyaluronan matrix.",
keywords = "Brain, Hyaluronan, Lectican/hyalectan, Link protein, Nodes of Ranvier, Proteoglycan",
author = "Toshitaka Oohashi and Yoshifumi Ninomiya",
year = "2003",
month = "3",
language = "English",
volume = "35",
pages = "25--30",
journal = "Connective Tissue",
issn = "0916-572X",
publisher = "Japanese Society For Connective Tissue Research",
number = "1",

}

TY - JOUR

T1 - Brain link proteins

T2 - New insights for hyaluronan-binding proteoglycans in brain

AU - Oohashi, Toshitaka

AU - Ninomiya, Yoshifumi

PY - 2003/3

Y1 - 2003/3

N2 - Link protein is originally characterized as an abundant extracellular matrix protein in cartilage and named Crt11. It can stabilize aggregates of aggrecan and hyaluronan, giving cartilage its tensile strength. Similarly to the cartilage matrix, a high content of hyaluronan matrix has also been recognized in the brain matrix. Subsequently, several hyaluronan binding chondroitin sulphate proteoglycans, called lecticans, have been identified as the abundant extracellular matrix molecules in the developing and/or adult brain. Other than Crt11, brain-specific link protein gene, Bra11, was cloned recently. The two link proteins (LPs), old and new, are differentially expressed and seemed to be coordinately expressed with lecticans in the brain. In this review, we will focus on these brain link proteins that may play crucial roles in hyaluronan matrix.

AB - Link protein is originally characterized as an abundant extracellular matrix protein in cartilage and named Crt11. It can stabilize aggregates of aggrecan and hyaluronan, giving cartilage its tensile strength. Similarly to the cartilage matrix, a high content of hyaluronan matrix has also been recognized in the brain matrix. Subsequently, several hyaluronan binding chondroitin sulphate proteoglycans, called lecticans, have been identified as the abundant extracellular matrix molecules in the developing and/or adult brain. Other than Crt11, brain-specific link protein gene, Bra11, was cloned recently. The two link proteins (LPs), old and new, are differentially expressed and seemed to be coordinately expressed with lecticans in the brain. In this review, we will focus on these brain link proteins that may play crucial roles in hyaluronan matrix.

KW - Brain

KW - Hyaluronan

KW - Lectican/hyalectan

KW - Link protein

KW - Nodes of Ranvier

KW - Proteoglycan

UR - http://www.scopus.com/inward/record.url?scp=0037357601&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0037357601&partnerID=8YFLogxK

M3 - Article

AN - SCOPUS:0037357601

VL - 35

SP - 25

EP - 30

JO - Connective Tissue

JF - Connective Tissue

SN - 0916-572X

IS - 1

ER -