Abstract
Link protein is originally characterized as an abundant extracellular matrix protein in cartilage and named Crt11. It can stabilize aggregates of aggrecan and hyaluronan, giving cartilage its tensile strength. Similarly to the cartilage matrix, a high content of hyaluronan matrix has also been recognized in the brain matrix. Subsequently, several hyaluronan binding chondroitin sulphate proteoglycans, called lecticans, have been identified as the abundant extracellular matrix molecules in the developing and/or adult brain. Other than Crt11, brain-specific link protein gene, Bra11, was cloned recently. The two link proteins (LPs), old and new, are differentially expressed and seemed to be coordinately expressed with lecticans in the brain. In this review, we will focus on these brain link proteins that may play crucial roles in hyaluronan matrix.
| Original language | English |
|---|---|
| Pages (from-to) | 25-30 |
| Number of pages | 6 |
| Journal | Connective Tissue |
| Volume | 35 |
| Issue number | 1 |
| Publication status | Published - Mar 2003 |
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Keywords
- Brain
- Hyaluronan
- Lectican/hyalectan
- Link protein
- Nodes of Ranvier
- Proteoglycan
ASJC Scopus subject areas
- Rheumatology
Cite this
Brain link proteins : New insights for hyaluronan-binding proteoglycans in brain. / Oohashi, Toshitaka; Ninomiya, Yoshifumi.
In: Connective Tissue, Vol. 35, No. 1, 03.2003, p. 25-30.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Brain link proteins
T2 - New insights for hyaluronan-binding proteoglycans in brain
AU - Oohashi, Toshitaka
AU - Ninomiya, Yoshifumi
PY - 2003/3
Y1 - 2003/3
N2 - Link protein is originally characterized as an abundant extracellular matrix protein in cartilage and named Crt11. It can stabilize aggregates of aggrecan and hyaluronan, giving cartilage its tensile strength. Similarly to the cartilage matrix, a high content of hyaluronan matrix has also been recognized in the brain matrix. Subsequently, several hyaluronan binding chondroitin sulphate proteoglycans, called lecticans, have been identified as the abundant extracellular matrix molecules in the developing and/or adult brain. Other than Crt11, brain-specific link protein gene, Bra11, was cloned recently. The two link proteins (LPs), old and new, are differentially expressed and seemed to be coordinately expressed with lecticans in the brain. In this review, we will focus on these brain link proteins that may play crucial roles in hyaluronan matrix.
AB - Link protein is originally characterized as an abundant extracellular matrix protein in cartilage and named Crt11. It can stabilize aggregates of aggrecan and hyaluronan, giving cartilage its tensile strength. Similarly to the cartilage matrix, a high content of hyaluronan matrix has also been recognized in the brain matrix. Subsequently, several hyaluronan binding chondroitin sulphate proteoglycans, called lecticans, have been identified as the abundant extracellular matrix molecules in the developing and/or adult brain. Other than Crt11, brain-specific link protein gene, Bra11, was cloned recently. The two link proteins (LPs), old and new, are differentially expressed and seemed to be coordinately expressed with lecticans in the brain. In this review, we will focus on these brain link proteins that may play crucial roles in hyaluronan matrix.
KW - Brain
KW - Hyaluronan
KW - Lectican/hyalectan
KW - Link protein
KW - Nodes of Ranvier
KW - Proteoglycan
UR - http://www.scopus.com/inward/record.url?scp=0037357601&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0037357601&partnerID=8YFLogxK
M3 - Article
VL - 35
SP - 25
EP - 30
JO - Connective Tissue
JF - Connective Tissue
SN - 0916-572X
IS - 1
ER -