Brachial intima-media thickness is associated with coronary artery atherosclerosis in patients with diabetes mellitus

Tamaki Ono, Toru Miyoshi, Yuko Ohno, Kazuhiro Osawa, Yoichi Takaya, Takashi Miki, Keishi Ichikawa, Hiroshi Ito

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)


Coronary artery calcification (CAC) as measured by computed tomography is a strong predictor of coronary artery disease. The brachial intima-media thickness (IMT) was recently reported to be associated with cardiovascular risk factors. This study investigated the association of brachial IMT with CAC, which is a marker of coronary artery atherosclerosis, in patients with diabetes. We enrolled 292 patients with diabetes (mean age, 65 ± 12 years; 59% men) who underwent both endothelial function testing and computed tomography for risk assessment of coronary artery disease. Flow-mediated dilation (FMD) and IMT in the brachial artery were measured with a specialized machine. FMD was lower and brachial IMT was thicker in patients with than without CAC. The CAC score was significantly correlated with both brachial IMT and FMD, while the multivariate logistic analysis demonstrated that brachial IMT (> 0.32 mm) but not FMD (< 5.1%) was significantly associated with the presence of CAC (odds ratio, 2.03; 95% confidence interval, 1.10–3.77; p = 0.02). The receiver operating characteristic curve analysis showed that the area under the curve for discriminating patients with CAC was 0.67 for IMT (p < 0.001) and 0.62 for FMD (p < 0.001). When patients were classified into four groups based on brachial IMT and FMD, the CAC score was higher in patients with thicker brachial IMT and lower FMD than in patients of the other groups (p < 0.001). Measurement of brachial IMT could be useful for the risk assessment of patients with diabetes.

Original languageEnglish
Pages (from-to)1405-1411
Number of pages7
JournalHeart and Vessels
Issue number9
Publication statusPublished - Sept 13 2019


  • Coronary artery calcification
  • Endothelial function
  • Flow-mediated dilatation
  • Intima-media thickness

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


Dive into the research topics of 'Brachial intima-media thickness is associated with coronary artery atherosclerosis in patients with diabetes mellitus'. Together they form a unique fingerprint.

Cite this