Brachial intima-media thickness is associated with coronary artery atherosclerosis in patients with diabetes mellitus

Tamaki Ono, Toru Miyoshi, Yuko Ohno, Kazuhiro Osawa, Yoichi Takaya, Takashi Miki, Keishi Ichikawa, Hiroshi Itoh

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Coronary artery calcification (CAC) as measured by computed tomography is a strong predictor of coronary artery disease. The brachial intima-media thickness (IMT) was recently reported to be associated with cardiovascular risk factors. This study investigated the association of brachial IMT with CAC, which is a marker of coronary artery atherosclerosis, in patients with diabetes. We enrolled 292 patients with diabetes (mean age, 65 ± 12 years; 59% men) who underwent both endothelial function testing and computed tomography for risk assessment of coronary artery disease. Flow-mediated dilation (FMD) and IMT in the brachial artery were measured with a specialized machine. FMD was lower and brachial IMT was thicker in patients with than without CAC. The CAC score was significantly correlated with both brachial IMT and FMD, while the multivariate logistic analysis demonstrated that brachial IMT (> 0.32 mm) but not FMD (< 5.1%) was significantly associated with the presence of CAC (odds ratio, 2.03; 95% confidence interval, 1.10–3.77; p = 0.02). The receiver operating characteristic curve analysis showed that the area under the curve for discriminating patients with CAC was 0.67 for IMT (p < 0.001) and 0.62 for FMD (p < 0.001). When patients were classified into four groups based on brachial IMT and FMD, the CAC score was higher in patients with thicker brachial IMT and lower FMD than in patients of the other groups (p < 0.001). Measurement of brachial IMT could be useful for the risk assessment of patients with diabetes.

Original languageEnglish
JournalHeart and Vessels
DOIs
Publication statusPublished - Jan 1 2019

Fingerprint

Coronary Artery Disease
Coronary Vessels
Diabetes Mellitus
Arm
Dilatation
Tomography
Brachial Artery
ROC Curve
Area Under Curve
Multivariate Analysis
Odds Ratio
Confidence Intervals

Keywords

  • Coronary artery calcification
  • Endothelial function
  • Flow-mediated dilatation
  • Intima-media thickness

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Brachial intima-media thickness is associated with coronary artery atherosclerosis in patients with diabetes mellitus. / Ono, Tamaki; Miyoshi, Toru; Ohno, Yuko; Osawa, Kazuhiro; Takaya, Yoichi; Miki, Takashi; Ichikawa, Keishi; Itoh, Hiroshi.

In: Heart and Vessels, 01.01.2019.

Research output: Contribution to journalArticle

@article{f0fcdf52596e4026aa4300575b2919b1,
title = "Brachial intima-media thickness is associated with coronary artery atherosclerosis in patients with diabetes mellitus",
abstract = "Coronary artery calcification (CAC) as measured by computed tomography is a strong predictor of coronary artery disease. The brachial intima-media thickness (IMT) was recently reported to be associated with cardiovascular risk factors. This study investigated the association of brachial IMT with CAC, which is a marker of coronary artery atherosclerosis, in patients with diabetes. We enrolled 292 patients with diabetes (mean age, 65 ± 12 years; 59{\%} men) who underwent both endothelial function testing and computed tomography for risk assessment of coronary artery disease. Flow-mediated dilation (FMD) and IMT in the brachial artery were measured with a specialized machine. FMD was lower and brachial IMT was thicker in patients with than without CAC. The CAC score was significantly correlated with both brachial IMT and FMD, while the multivariate logistic analysis demonstrated that brachial IMT (> 0.32 mm) but not FMD (< 5.1{\%}) was significantly associated with the presence of CAC (odds ratio, 2.03; 95{\%} confidence interval, 1.10–3.77; p = 0.02). The receiver operating characteristic curve analysis showed that the area under the curve for discriminating patients with CAC was 0.67 for IMT (p < 0.001) and 0.62 for FMD (p < 0.001). When patients were classified into four groups based on brachial IMT and FMD, the CAC score was higher in patients with thicker brachial IMT and lower FMD than in patients of the other groups (p < 0.001). Measurement of brachial IMT could be useful for the risk assessment of patients with diabetes.",
keywords = "Coronary artery calcification, Endothelial function, Flow-mediated dilatation, Intima-media thickness",
author = "Tamaki Ono and Toru Miyoshi and Yuko Ohno and Kazuhiro Osawa and Yoichi Takaya and Takashi Miki and Keishi Ichikawa and Hiroshi Itoh",
year = "2019",
month = "1",
day = "1",
doi = "10.1007/s00380-019-01371-8",
language = "English",
journal = "Heart and Vessels",
issn = "0910-8327",
publisher = "Springer Japan",

}

TY - JOUR

T1 - Brachial intima-media thickness is associated with coronary artery atherosclerosis in patients with diabetes mellitus

AU - Ono, Tamaki

AU - Miyoshi, Toru

AU - Ohno, Yuko

AU - Osawa, Kazuhiro

AU - Takaya, Yoichi

AU - Miki, Takashi

AU - Ichikawa, Keishi

AU - Itoh, Hiroshi

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Coronary artery calcification (CAC) as measured by computed tomography is a strong predictor of coronary artery disease. The brachial intima-media thickness (IMT) was recently reported to be associated with cardiovascular risk factors. This study investigated the association of brachial IMT with CAC, which is a marker of coronary artery atherosclerosis, in patients with diabetes. We enrolled 292 patients with diabetes (mean age, 65 ± 12 years; 59% men) who underwent both endothelial function testing and computed tomography for risk assessment of coronary artery disease. Flow-mediated dilation (FMD) and IMT in the brachial artery were measured with a specialized machine. FMD was lower and brachial IMT was thicker in patients with than without CAC. The CAC score was significantly correlated with both brachial IMT and FMD, while the multivariate logistic analysis demonstrated that brachial IMT (> 0.32 mm) but not FMD (< 5.1%) was significantly associated with the presence of CAC (odds ratio, 2.03; 95% confidence interval, 1.10–3.77; p = 0.02). The receiver operating characteristic curve analysis showed that the area under the curve for discriminating patients with CAC was 0.67 for IMT (p < 0.001) and 0.62 for FMD (p < 0.001). When patients were classified into four groups based on brachial IMT and FMD, the CAC score was higher in patients with thicker brachial IMT and lower FMD than in patients of the other groups (p < 0.001). Measurement of brachial IMT could be useful for the risk assessment of patients with diabetes.

AB - Coronary artery calcification (CAC) as measured by computed tomography is a strong predictor of coronary artery disease. The brachial intima-media thickness (IMT) was recently reported to be associated with cardiovascular risk factors. This study investigated the association of brachial IMT with CAC, which is a marker of coronary artery atherosclerosis, in patients with diabetes. We enrolled 292 patients with diabetes (mean age, 65 ± 12 years; 59% men) who underwent both endothelial function testing and computed tomography for risk assessment of coronary artery disease. Flow-mediated dilation (FMD) and IMT in the brachial artery were measured with a specialized machine. FMD was lower and brachial IMT was thicker in patients with than without CAC. The CAC score was significantly correlated with both brachial IMT and FMD, while the multivariate logistic analysis demonstrated that brachial IMT (> 0.32 mm) but not FMD (< 5.1%) was significantly associated with the presence of CAC (odds ratio, 2.03; 95% confidence interval, 1.10–3.77; p = 0.02). The receiver operating characteristic curve analysis showed that the area under the curve for discriminating patients with CAC was 0.67 for IMT (p < 0.001) and 0.62 for FMD (p < 0.001). When patients were classified into four groups based on brachial IMT and FMD, the CAC score was higher in patients with thicker brachial IMT and lower FMD than in patients of the other groups (p < 0.001). Measurement of brachial IMT could be useful for the risk assessment of patients with diabetes.

KW - Coronary artery calcification

KW - Endothelial function

KW - Flow-mediated dilatation

KW - Intima-media thickness

UR - http://www.scopus.com/inward/record.url?scp=85062680861&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85062680861&partnerID=8YFLogxK

U2 - 10.1007/s00380-019-01371-8

DO - 10.1007/s00380-019-01371-8

M3 - Article

C2 - 30834950

AN - SCOPUS:85062680861

JO - Heart and Vessels

JF - Heart and Vessels

SN - 0910-8327

ER -