Brachial-Ankle Pulse Wave Velocity Versus Its Stiffness Index β-Transformed Value as Risk Marker for Cardiovascular Disease

Hirofumi Tomiyama, Toshiaki Ohkuma, Toshiharu Ninomiya, Hiroki Nakano, Chisa Matsumoto, Alberto Avolio, Takahide Kohro, Yukihito Higashi, Tatsuya Maruhashi, Bonpei Takase, Toru Suzuki, Tomoko Ishizu, Shinichiro Ueda, Tsutomu Yamazaki, Tomoo Furumoto, Kazuomi Kario, Teruo Inoue, Shinji Koba, Yasuhiko Takemoto, Takuzo HanoMasataka Sata, Yutaka Ishibashi, Koichi Node, Koji Maemura, Yusuke Ohya, Taiji Furukawa, Hiroshi Ito, Taishiro Chikamori, Akira Yamashina

Research output: Contribution to journalArticle

Abstract

Background The difference in the predictive ability of the brachial-ankle pulse wave velocity (baPWV) and its stiffness index β-transformed value (β-baPWV, ie, baPWV adjusted for the pulse pressure) for the development of pathophysiological abnormalities related to cardiovascular disease or future occurrence of cardiovascular disease was examined. Methods and Results In study 1, a 7-year prospective observational study in cohorts of 3274 men and 3490 men, the area under the curve in the receiver operator characteristic curve analysis was higher for baPWV than for β-baPWV for predicting the development of hypertension (0.73, 95% CI=0.70 to 0.75 versus 0.59, 95% CI=0.56 to 0.62; P<0.01) and/or the development of retinopathy (0.78, 95% CI=0.73 to 0.82 versus 0.66, 95% CI=0.60 to 0.71; P<0.01) by the end of the study period. During study 2, a 3-year observation period on 511 patients with coronary artery disease, 72 cardiovascular events were confirmed. The C statistics of both markers for predicting the development of cardiovascular events were similar. Conclusions Stiffness index β transformation of the baPWV may attenuate the significance of the baPWV as a risk marker for development of pathophysiological abnormalities related to cardiovascular disease in male subjects.

Original languageEnglish
Pages (from-to)e013004
JournalJournal of the American Heart Association
Volume8
Issue number24
DOIs
Publication statusPublished - Dec 17 2019

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Keywords

  • arterial stiffness
  • blood pressure
  • hypertension
  • organ damage
  • stiffness index β

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Tomiyama, H., Ohkuma, T., Ninomiya, T., Nakano, H., Matsumoto, C., Avolio, A., Kohro, T., Higashi, Y., Maruhashi, T., Takase, B., Suzuki, T., Ishizu, T., Ueda, S., Yamazaki, T., Furumoto, T., Kario, K., Inoue, T., Koba, S., Takemoto, Y., ... Yamashina, A. (2019). Brachial-Ankle Pulse Wave Velocity Versus Its Stiffness Index β-Transformed Value as Risk Marker for Cardiovascular Disease. Journal of the American Heart Association, 8(24), e013004. https://doi.org/10.1161/JAHA.119.013004