Bovine and porcine trabecular cells produce prostaglandin F in response to cyclic mechanical stretching

Toshihiko Matsuo, Hisako Uchida, Nobuhiko Matsuo

Research output: Contribution to journalArticlepeer-review

33 Citations (Scopus)

Abstract

Bovine and porcine trabecular cells in Petri dish cultures were exposed to cyclic mechanical stretching of the dish bottom for 30 second cycles (2 Hertz) at a strain magnitude of 4.5 mm/m for up to 3 days. Growth rate of the cells was not affected by the stretching but production of prostaglandin F (PGF) increased. We believe one stimulus for production of PGF in trabecular cells may be the stretching of the trabecular meshwork caused by changes in aqueous flow and intraocular pressure.

Original languageEnglish
Pages (from-to)289-296
Number of pages8
JournalJapanese Journal of Ophthalmology
Volume40
Issue number3
Publication statusPublished - Dec 1 1996

Keywords

  • Cyclic mechanical stretching
  • PGF
  • Prostaglandins
  • Trabecular cells

ASJC Scopus subject areas

  • Ophthalmology

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