Bovine and porcine trabecular cells produce prostaglandin F2α in response to cyclic mechanical stretching

Toshihiko Matsuo, Hisako Uchida, Nobuhiko Matsuo

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

Bovine and porcine trabecular cells in Petri dish cultures were exposed to cyclic mechanical stretching of the dish bottom for 30 second cycles (2 Hertz) at a strain magnitude of 4.5 mm/m for up to 3 days. Growth rate of the cells was not affected by the stretching but production of prostaglandin F (PGF) increased. We believe one stimulus for production of PGF in trabecular cells may be the stretching of the trabecular meshwork caused by changes in aqueous flow and intraocular pressure.

Original languageEnglish
Pages (from-to)289-296
Number of pages8
JournalJapanese Journal of Ophthalmology
Volume40
Issue number3
Publication statusPublished - 1996

Fingerprint

Dinoprost
Swine
Trabecular Meshwork
Intraocular Pressure
Growth

Keywords

  • Cyclic mechanical stretching
  • PGF
  • Prostaglandins
  • Trabecular cells

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Bovine and porcine trabecular cells produce prostaglandin F2α in response to cyclic mechanical stretching. / Matsuo, Toshihiko; Uchida, Hisako; Matsuo, Nobuhiko.

In: Japanese Journal of Ophthalmology, Vol. 40, No. 3, 1996, p. 289-296.

Research output: Contribution to journalArticle

@article{10c84bc76df3414d9e0057ecd40334dd,
title = "Bovine and porcine trabecular cells produce prostaglandin F2α in response to cyclic mechanical stretching",
abstract = "Bovine and porcine trabecular cells in Petri dish cultures were exposed to cyclic mechanical stretching of the dish bottom for 30 second cycles (2 Hertz) at a strain magnitude of 4.5 mm/m for up to 3 days. Growth rate of the cells was not affected by the stretching but production of prostaglandin F2α (PGF2α) increased. We believe one stimulus for production of PGF2α in trabecular cells may be the stretching of the trabecular meshwork caused by changes in aqueous flow and intraocular pressure.",
keywords = "Cyclic mechanical stretching, PGF, Prostaglandins, Trabecular cells",
author = "Toshihiko Matsuo and Hisako Uchida and Nobuhiko Matsuo",
year = "1996",
language = "English",
volume = "40",
pages = "289--296",
journal = "Japanese Journal of Ophthalmology",
issn = "0021-5155",
publisher = "Springer Japan",
number = "3",

}

TY - JOUR

T1 - Bovine and porcine trabecular cells produce prostaglandin F2α in response to cyclic mechanical stretching

AU - Matsuo, Toshihiko

AU - Uchida, Hisako

AU - Matsuo, Nobuhiko

PY - 1996

Y1 - 1996

N2 - Bovine and porcine trabecular cells in Petri dish cultures were exposed to cyclic mechanical stretching of the dish bottom for 30 second cycles (2 Hertz) at a strain magnitude of 4.5 mm/m for up to 3 days. Growth rate of the cells was not affected by the stretching but production of prostaglandin F2α (PGF2α) increased. We believe one stimulus for production of PGF2α in trabecular cells may be the stretching of the trabecular meshwork caused by changes in aqueous flow and intraocular pressure.

AB - Bovine and porcine trabecular cells in Petri dish cultures were exposed to cyclic mechanical stretching of the dish bottom for 30 second cycles (2 Hertz) at a strain magnitude of 4.5 mm/m for up to 3 days. Growth rate of the cells was not affected by the stretching but production of prostaglandin F2α (PGF2α) increased. We believe one stimulus for production of PGF2α in trabecular cells may be the stretching of the trabecular meshwork caused by changes in aqueous flow and intraocular pressure.

KW - Cyclic mechanical stretching

KW - PGF

KW - Prostaglandins

KW - Trabecular cells

UR - http://www.scopus.com/inward/record.url?scp=0029909096&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0029909096&partnerID=8YFLogxK

M3 - Article

C2 - 8988417

AN - SCOPUS:0029909096

VL - 40

SP - 289

EP - 296

JO - Japanese Journal of Ophthalmology

JF - Japanese Journal of Ophthalmology

SN - 0021-5155

IS - 3

ER -