TY - JOUR
T1 - Boron concentration measurements by alpha spectrometry and quantitative neutron autoradiography in cells and tissues treated with different boronated formulations and administration protocols
AU - Bortolussi, Silva
AU - Ciani, Laura
AU - Postuma, Ian
AU - Protti, Nicoletta
AU - Luca Reversi, Reversi
AU - Bruschi, Piero
AU - Ferrari, Cinzia
AU - Cansolino, Laura
AU - Panza, Luigi
AU - Ristori, Sandra
AU - Altieri, Saverio
PY - 2014/6
Y1 - 2014/6
N2 - The possibility to measure boron concentration with high precision in tissues that will be irradiated represents a fundamental step for a safe and effective BNCT treatment. In Pavia, two techniques have been used for this purpose, a quantitative method based on charged particles spectrometry and a boron biodistribution imaging based on neutron autoradiography. A quantitative method to determine boron concentration by neutron autoradiography has been recently set-up and calibrated for the measurement of biological samples, both solid and liquid, in the frame of the feasibility study of BNCT. This technique was calibrated and the obtained results were cross checked with those of α spectrometry, in order to validate them. The comparisons were performed using tissues taken form animals treated with different boron administration protocols. Subsequently the quantitative neutron autoradiography was employed to measure osteosarcoma cell samples treated with BPA and with new boronated formulations.
AB - The possibility to measure boron concentration with high precision in tissues that will be irradiated represents a fundamental step for a safe and effective BNCT treatment. In Pavia, two techniques have been used for this purpose, a quantitative method based on charged particles spectrometry and a boron biodistribution imaging based on neutron autoradiography. A quantitative method to determine boron concentration by neutron autoradiography has been recently set-up and calibrated for the measurement of biological samples, both solid and liquid, in the frame of the feasibility study of BNCT. This technique was calibrated and the obtained results were cross checked with those of α spectrometry, in order to validate them. The comparisons were performed using tissues taken form animals treated with different boron administration protocols. Subsequently the quantitative neutron autoradiography was employed to measure osteosarcoma cell samples treated with BPA and with new boronated formulations.
KW - BNCT
KW - Boron measurements
KW - Boronated liposomes
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U2 - 10.1016/j.apradiso.2013.12.001
DO - 10.1016/j.apradiso.2013.12.001
M3 - Article
C2 - 24387908
AN - SCOPUS:84901833592
VL - 88
SP - 78
EP - 80
JO - Applied Radiation and Isotopes
JF - Applied Radiation and Isotopes
SN - 0969-8043
ER -