Boron concentration measurements by alpha spectrometry and quantitative neutron autoradiography in cells and tissues treated with different boronated formulations and administration protocols

Silva Bortolussi, Laura Ciani, Ian Postuma, Nicoletta Protti, Reversi Luca Reversi, Piero Bruschi, Cinzia Ferrari, Laura Cansolino, Luigi Panza, Sandra Ristori, Saverio Altieri

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)

Abstract

The possibility to measure boron concentration with high precision in tissues that will be irradiated represents a fundamental step for a safe and effective BNCT treatment. In Pavia, two techniques have been used for this purpose, a quantitative method based on charged particles spectrometry and a boron biodistribution imaging based on neutron autoradiography. A quantitative method to determine boron concentration by neutron autoradiography has been recently set-up and calibrated for the measurement of biological samples, both solid and liquid, in the frame of the feasibility study of BNCT. This technique was calibrated and the obtained results were cross checked with those of α spectrometry, in order to validate them. The comparisons were performed using tissues taken form animals treated with different boron administration protocols. Subsequently the quantitative neutron autoradiography was employed to measure osteosarcoma cell samples treated with BPA and with new boronated formulations.

Original languageEnglish
Pages (from-to)78-80
Number of pages3
JournalApplied Radiation and Isotopes
Volume88
DOIs
Publication statusPublished - Jun 2014
Externally publishedYes

Keywords

  • BNCT
  • Boron measurements
  • Boronated liposomes

ASJC Scopus subject areas

  • Radiation

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