Bone mineral density in steroid-dependent asthma assessed by peripheral quantitative computed tomography

H. Tsugeno, M. Nakai, M. Okamoto, S. Harada, T. Mifune, Fumihiro Mitsunobu, Kozo Ashida, Y. Hosaki, Y. Tanizaki, T. Tsuji

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Chronic use of systemic glucocorticoids results in progressive bone loss and pathologic fractures. This study identified the predictive variables for bone loss and used peripheral quantitative computed tomography (pQCT) to measure changes in cortical and trabecular bone in patients receiving systemic glucocorticoid therapy of prednisone 15.4 g. Eighty-four asthmatic patients were included in the study. Vertebral fractures were diagnosed via plain spinal radiograms, pQCT was used to measure cortical and trabecular bone mineral density. Multiple regression analysis identified variables with predictive value. The cumulative dose of glucocorticoid correlated with the bone mineral density (p

Original languageEnglish
Pages (from-to)923-927
Number of pages5
JournalEuropean Respiratory Journal
Volume14
Issue number4
DOIs
Publication statusPublished - 1999

Fingerprint

Bone Density
Glucocorticoids
Asthma
Steroids
Tomography
Spontaneous Fractures
Bone Fractures
Prednisone
Regression Analysis
Bone and Bones
Cortical Bone
Cancellous Bone
Therapeutics

Keywords

  • Bronchial asthma
  • Cortical bone
  • Peripheral quantitative computed tomography
  • Systemic glucocorticoid
  • Trabecular bone
  • Vertebral fracture

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Cite this

Bone mineral density in steroid-dependent asthma assessed by peripheral quantitative computed tomography. / Tsugeno, H.; Nakai, M.; Okamoto, M.; Harada, S.; Mifune, T.; Mitsunobu, Fumihiro; Ashida, Kozo; Hosaki, Y.; Tanizaki, Y.; Tsuji, T.

In: European Respiratory Journal, Vol. 14, No. 4, 1999, p. 923-927.

Research output: Contribution to journalArticle

Tsugeno, H. ; Nakai, M. ; Okamoto, M. ; Harada, S. ; Mifune, T. ; Mitsunobu, Fumihiro ; Ashida, Kozo ; Hosaki, Y. ; Tanizaki, Y. ; Tsuji, T. / Bone mineral density in steroid-dependent asthma assessed by peripheral quantitative computed tomography. In: European Respiratory Journal. 1999 ; Vol. 14, No. 4. pp. 923-927.
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