BMP action in the pituitary: Its possible role in modulating somatostatin sensitivity in pituitary tumor cells

Fumio Otsuka, Naoko Tsukamoto, Tomoko Miyoshi, Yasumasa Iwasaki, Hirofumi Makino

Research output: Contribution to journalReview article

14 Citations (Scopus)

Abstract

The existence of a functional bone morphogenetic protein (BMP) system in the pituitary has been recognized. Recent studies have provided evidence that BMPs elicit differential actions in the regulation of prolactin (PRL) and adrenocorticotropin (ACTH) release in lactotropinoma and corticotropinoma cells, respectively. BMPs play a key role in the modulation of somatostatin receptor (SSTR) sensitivity of lactosomatotrope cells in an autocrine/paracrine manner. In addition, SSTR action enhances BMP responsiveness in corticotrope cells. The functional link between BMP receptor signaling and SSTR actions may be crucial for individual tolerance to somatostatin analogs for controlling PRL and ACTH production. Adjustment of the endogenous SSTR sensitivity may be an effective strategy to inhibit the growth activity and hormonal productivity of intractable pituitary tumors.

Original languageEnglish
Pages (from-to)105-110
Number of pages6
JournalMolecular and cellular endocrinology
Volume349
Issue number2
DOIs
Publication statusPublished - Feb 26 2012

Keywords

  • Bone morphogenetic protein
  • Corticotrope
  • Lactotrope
  • Pituitary adenoma
  • Somatostatin

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Endocrinology

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