BMP-2-loaded silica nanotube fibrous meshes for bone generation

Song Chen; Xuetao Shi; Hiromi Morita; Jie Li; Nobuhiro Ogawa; Toshiyuki Ikoma; Satoshi Hayakawa; Yuki Shirosaki; Akiyoshi Osaka; Nobutaka Hanagata

doi:10.1088/1468-6996/12/6/065003

BMP-2-loaded silica nanotube fibrous meshes for bone generation

Song Chen, Xuetao Shi, Hiromi Morita, Jie Li, Nobuhiro Ogawa, Toshiyuki Ikoma, Satoshi Hayakawa, Yuki Shirosaki, Akiyoshi Osaka, Nobutaka Hanagata

Research output: Contribution to journal › Article › peer-review

15 Citations (Scopus)

Abstract

Silica nanotube fibrous meshes were fabricated as multiple functional matrices for both delivering bone morphological protein-2 (BMP-2) and supporting osteoblast attachment and proliferation. The meshes were fabricated via a collagen-templated sol-gel route and consisted of tubular silica with open ends. BMP-2 was loaded to the meshes by soaking in BMP-2 solution. The meshes effectively enabled the attachment and proliferation of osteoblast MC3T3-E1 cells and delivered bioactive BMP-2 to stimulate cell differentiation. These results demonstrate the potential use of the meshes in bone generation applications.

Original language	English
Article number	065003
Journal	Science and Technology of Advanced Materials
Volume	12
Issue number	6
DOIs	https://doi.org/10.1088/1468-6996/12/6/065003
Publication status	Published - Dec 2011

Keywords

bone
bone morphological protein-2 (BMP-2)
osteoblasts
silica nanotube

ASJC Scopus subject areas

Materials Science(all)

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10.1088/1468-6996/12/6/065003

Cite this

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abstract = "Silica nanotube fibrous meshes were fabricated as multiple functional matrices for both delivering bone morphological protein-2 (BMP-2) and supporting osteoblast attachment and proliferation. The meshes were fabricated via a collagen-templated sol-gel route and consisted of tubular silica with open ends. BMP-2 was loaded to the meshes by soaking in BMP-2 solution. The meshes effectively enabled the attachment and proliferation of osteoblast MC3T3-E1 cells and delivered bioactive BMP-2 to stimulate cell differentiation. These results demonstrate the potential use of the meshes in bone generation applications.",

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T1 - BMP-2-loaded silica nanotube fibrous meshes for bone generation

AU - Chen, Song

AU - Shi, Xuetao

AU - Morita, Hiromi

AU - Li, Jie

AU - Ogawa, Nobuhiro

AU - Ikoma, Toshiyuki

AU - Hayakawa, Satoshi

AU - Shirosaki, Yuki

AU - Osaka, Akiyoshi

AU - Hanagata, Nobutaka

PY - 2011/12

Y1 - 2011/12

N2 - Silica nanotube fibrous meshes were fabricated as multiple functional matrices for both delivering bone morphological protein-2 (BMP-2) and supporting osteoblast attachment and proliferation. The meshes were fabricated via a collagen-templated sol-gel route and consisted of tubular silica with open ends. BMP-2 was loaded to the meshes by soaking in BMP-2 solution. The meshes effectively enabled the attachment and proliferation of osteoblast MC3T3-E1 cells and delivered bioactive BMP-2 to stimulate cell differentiation. These results demonstrate the potential use of the meshes in bone generation applications.

AB - Silica nanotube fibrous meshes were fabricated as multiple functional matrices for both delivering bone morphological protein-2 (BMP-2) and supporting osteoblast attachment and proliferation. The meshes were fabricated via a collagen-templated sol-gel route and consisted of tubular silica with open ends. BMP-2 was loaded to the meshes by soaking in BMP-2 solution. The meshes effectively enabled the attachment and proliferation of osteoblast MC3T3-E1 cells and delivered bioactive BMP-2 to stimulate cell differentiation. These results demonstrate the potential use of the meshes in bone generation applications.

KW - bone

KW - bone morphological protein-2 (BMP-2)

KW - osteoblasts

KW - silica nanotube

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BMP-2-loaded silica nanotube fibrous meshes for bone generation

Abstract

Keywords

ASJC Scopus subject areas

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