BMP-2-loaded silica nanotube fibrous meshes for bone generation

Song Chen, Xuetao Shi, Hiromi Morita, Jie Li, Nobuhiro Ogawa, Toshiyuki Ikoma, Satoshi Hayakawa, Yuki Shirosaki, Akiyoshi Osaka, Nobutaka Hanagata

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11 Citations (Scopus)


Silica nanotube fibrous meshes were fabricated as multiple functional matrices for both delivering bone morphological protein-2 (BMP-2) and supporting osteoblast attachment and proliferation. The meshes were fabricated via a collagen-templated sol-gel route and consisted of tubular silica with open ends. BMP-2 was loaded to the meshes by soaking in BMP-2 solution. The meshes effectively enabled the attachment and proliferation of osteoblast MC3T3-E1 cells and delivered bioactive BMP-2 to stimulate cell differentiation. These results demonstrate the potential use of the meshes in bone generation applications.

Original languageEnglish
Article number065003
JournalScience and Technology of Advanced Materials
Issue number6
Publication statusPublished - Dec 1 2011


  • bone
  • bone morphological protein-2 (BMP-2)
  • osteoblasts
  • silica nanotube

ASJC Scopus subject areas

  • Materials Science(all)

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  • Cite this

    Chen, S., Shi, X., Morita, H., Li, J., Ogawa, N., Ikoma, T., Hayakawa, S., Shirosaki, Y., Osaka, A., & Hanagata, N. (2011). BMP-2-loaded silica nanotube fibrous meshes for bone generation. Science and Technology of Advanced Materials, 12(6), [065003].