BMP-2-loaded silica nanotube fibrous meshes for bone generation

Song Chen, Xuetao Shi, Hiromi Morita, Jie Li, Nobuhiro Ogawa, Toshiyuki Ikoma, Satoshi Hayakawa, Yuki Shirosaki, Akiyoshi Osaka, Nobutaka Hanagata

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11 Citations (Scopus)

Abstract

Silica nanotube fibrous meshes were fabricated as multiple functional matrices for both delivering bone morphological protein-2 (BMP-2) and supporting osteoblast attachment and proliferation. The meshes were fabricated via a collagen-templated sol-gel route and consisted of tubular silica with open ends. BMP-2 was loaded to the meshes by soaking in BMP-2 solution. The meshes effectively enabled the attachment and proliferation of osteoblast MC3T3-E1 cells and delivered bioactive BMP-2 to stimulate cell differentiation. These results demonstrate the potential use of the meshes in bone generation applications.

Original languageEnglish
Article number065003
JournalScience and Technology of Advanced Materials
Volume12
Issue number6
DOIs
Publication statusPublished - Dec 1 2011

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Keywords

  • bone
  • bone morphological protein-2 (BMP-2)
  • osteoblasts
  • silica nanotube

ASJC Scopus subject areas

  • Materials Science(all)

Cite this

Chen, S., Shi, X., Morita, H., Li, J., Ogawa, N., Ikoma, T., Hayakawa, S., Shirosaki, Y., Osaka, A., & Hanagata, N. (2011). BMP-2-loaded silica nanotube fibrous meshes for bone generation. Science and Technology of Advanced Materials, 12(6), [065003]. https://doi.org/10.1088/1468-6996/12/6/065003