Blood transfusion and postoperative plasma cytokine antagonist levels in colorectal cancer patients

H. Iwagaki, Takahito Yagi, N. Urushihara, Y. Morimoto, A. Jikuhara, H. Isozaki, N. Tanaka

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Background/Aims: Postoperative cytokine antagonist response affects various factors. However, excessive stress responses are deleterious as increased plasma concentration of cytokine antagonists may induce an impaired immune system. Methodology: We determined plasma levels of cortisol, IL-1ra, and sTNF-R55 in 20 patients who had undergone resection of colorectal carcinoma. Ten patients had a blood transfusion during the operation (invasive group), but 10 patients had received no blood transfusion (less invasive group). Plasma levels of cytokine antagonists were determined before operation (POD 0) and POD-1, -2 and -7. Results: Postoperative plasma cortisol and sTNF-R55 levels were significantly elevated on POD-1 in the invasive group. Plasma IL-1ra levels were significantly increased on POD-1 in both the invasive and less invasive groups. Conclusions: The present study demonstrated that perioperative allogeneic blood transfusion can induce an excessive production of cortisol and sTNF-R55, and might be deleterious.

Original languageEnglish
Pages (from-to)1351-1354
Number of pages4
JournalHepato-Gastroenterology
Volume48
Issue number41
Publication statusPublished - 2001

Fingerprint

Blood Transfusion
Colorectal Neoplasms
Cytokines
Interleukin 1 Receptor Antagonist Protein
Hydrocortisone
Immune System

Keywords

  • Blood transfusion
  • Colorectal cancer
  • Cytokine antagonist

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Iwagaki, H., Yagi, T., Urushihara, N., Morimoto, Y., Jikuhara, A., Isozaki, H., & Tanaka, N. (2001). Blood transfusion and postoperative plasma cytokine antagonist levels in colorectal cancer patients. Hepato-Gastroenterology, 48(41), 1351-1354.

Blood transfusion and postoperative plasma cytokine antagonist levels in colorectal cancer patients. / Iwagaki, H.; Yagi, Takahito; Urushihara, N.; Morimoto, Y.; Jikuhara, A.; Isozaki, H.; Tanaka, N.

In: Hepato-Gastroenterology, Vol. 48, No. 41, 2001, p. 1351-1354.

Research output: Contribution to journalArticle

Iwagaki, H, Yagi, T, Urushihara, N, Morimoto, Y, Jikuhara, A, Isozaki, H & Tanaka, N 2001, 'Blood transfusion and postoperative plasma cytokine antagonist levels in colorectal cancer patients', Hepato-Gastroenterology, vol. 48, no. 41, pp. 1351-1354.
Iwagaki H, Yagi T, Urushihara N, Morimoto Y, Jikuhara A, Isozaki H et al. Blood transfusion and postoperative plasma cytokine antagonist levels in colorectal cancer patients. Hepato-Gastroenterology. 2001;48(41):1351-1354.
Iwagaki, H. ; Yagi, Takahito ; Urushihara, N. ; Morimoto, Y. ; Jikuhara, A. ; Isozaki, H. ; Tanaka, N. / Blood transfusion and postoperative plasma cytokine antagonist levels in colorectal cancer patients. In: Hepato-Gastroenterology. 2001 ; Vol. 48, No. 41. pp. 1351-1354.
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