Abstract
Aim. Cold water-immersion induces vasoconstriction with an elevation of blood endothelin-1, which is a potent vasoconstrictor peptide, in patients with primary Raynaud's phenomenon (PRP). However, physiological involvement of endothelin-1 in cold-induced vasodilation (CIVD) remains to be elucidated. Methods. We monitored changes of finger blood flow during cold water (10°C) immersion and assayed blood endothelin-1 in 7 PRP patients and 7 workers with vibration-induced white finger (VWF) and in the respective control subjects. Results. While significant reductions in finger blood flow at 2 min after the immersion were observed in PRP patients and VWF workers, its elevation at 4 min, which was considered to reflect CIVD, was recognized only in PRP patients. In healthy controls, blood endothelin-1 increased at 4 min and returned to the basal level immediately after the immersion. The increase in blood endothelin-1 at 4 min in PRP patients was greater than that in controls, and continued even after the immersion. Conversely, the increase neither at 4 min nor after immersion was seen in VWF workers. Local vascular changes produced by repetitive vibration may be responsible for the attenuated CIVD and unchanged blood endothelin-1 during cold water-immersion in VWF workers. Conclusion. Our results showing elevated blood endothelin-1 during and after immersion in PRP contrast with that in VWF suggesting that endothelin-1 is related to sympathetic hyperactivity which is more involved in PRP rather than VWF. It seems unlikely that endothelin-1 is functionally or directly associated with CIVD.
| Original language | English |
|---|---|
| Pages (from-to) | 243-249 |
| Number of pages | 7 |
| Journal | International Angiology |
| Volume | 22 |
| Issue number | 3 |
| Publication status | Published - Sep 2003 |
| Externally published | Yes |
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Keywords
- Arterio-venous anastomosis
- Blood pressure
- Cold
- Fingers
- Sympathetic nervous system
- Vasoconstriction
ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine
Cite this
Blood endothelin-1 and cold-induced vasodilation in patients with primary Raynauld's phenomenon and workers with vibration-induced white finger. / Nakamura, Hiro; Matsuzaki, I.; Hatta, K.; Nagase, H.; Nobokuni, Y.; Kambayashi, Y.; Ogino, Keiki.
In: International Angiology, Vol. 22, No. 3, 09.2003, p. 243-249.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Blood endothelin-1 and cold-induced vasodilation in patients with primary Raynauld's phenomenon and workers with vibration-induced white finger
AU - Nakamura, Hiro
AU - Matsuzaki, I.
AU - Hatta, K.
AU - Nagase, H.
AU - Nobokuni, Y.
AU - Kambayashi, Y.
AU - Ogino, Keiki
PY - 2003/9
Y1 - 2003/9
N2 - Aim. Cold water-immersion induces vasoconstriction with an elevation of blood endothelin-1, which is a potent vasoconstrictor peptide, in patients with primary Raynaud's phenomenon (PRP). However, physiological involvement of endothelin-1 in cold-induced vasodilation (CIVD) remains to be elucidated. Methods. We monitored changes of finger blood flow during cold water (10°C) immersion and assayed blood endothelin-1 in 7 PRP patients and 7 workers with vibration-induced white finger (VWF) and in the respective control subjects. Results. While significant reductions in finger blood flow at 2 min after the immersion were observed in PRP patients and VWF workers, its elevation at 4 min, which was considered to reflect CIVD, was recognized only in PRP patients. In healthy controls, blood endothelin-1 increased at 4 min and returned to the basal level immediately after the immersion. The increase in blood endothelin-1 at 4 min in PRP patients was greater than that in controls, and continued even after the immersion. Conversely, the increase neither at 4 min nor after immersion was seen in VWF workers. Local vascular changes produced by repetitive vibration may be responsible for the attenuated CIVD and unchanged blood endothelin-1 during cold water-immersion in VWF workers. Conclusion. Our results showing elevated blood endothelin-1 during and after immersion in PRP contrast with that in VWF suggesting that endothelin-1 is related to sympathetic hyperactivity which is more involved in PRP rather than VWF. It seems unlikely that endothelin-1 is functionally or directly associated with CIVD.
AB - Aim. Cold water-immersion induces vasoconstriction with an elevation of blood endothelin-1, which is a potent vasoconstrictor peptide, in patients with primary Raynaud's phenomenon (PRP). However, physiological involvement of endothelin-1 in cold-induced vasodilation (CIVD) remains to be elucidated. Methods. We monitored changes of finger blood flow during cold water (10°C) immersion and assayed blood endothelin-1 in 7 PRP patients and 7 workers with vibration-induced white finger (VWF) and in the respective control subjects. Results. While significant reductions in finger blood flow at 2 min after the immersion were observed in PRP patients and VWF workers, its elevation at 4 min, which was considered to reflect CIVD, was recognized only in PRP patients. In healthy controls, blood endothelin-1 increased at 4 min and returned to the basal level immediately after the immersion. The increase in blood endothelin-1 at 4 min in PRP patients was greater than that in controls, and continued even after the immersion. Conversely, the increase neither at 4 min nor after immersion was seen in VWF workers. Local vascular changes produced by repetitive vibration may be responsible for the attenuated CIVD and unchanged blood endothelin-1 during cold water-immersion in VWF workers. Conclusion. Our results showing elevated blood endothelin-1 during and after immersion in PRP contrast with that in VWF suggesting that endothelin-1 is related to sympathetic hyperactivity which is more involved in PRP rather than VWF. It seems unlikely that endothelin-1 is functionally or directly associated with CIVD.
KW - Arterio-venous anastomosis
KW - Blood pressure
KW - Cold
KW - Fingers
KW - Sympathetic nervous system
KW - Vasoconstriction
UR - http://www.scopus.com/inward/record.url?scp=0344897587&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0344897587&partnerID=8YFLogxK
M3 - Article
C2 - 14612851
AN - SCOPUS:0344897587
VL - 22
SP - 243
EP - 249
JO - International Angiology
JF - International Angiology
SN - 0392-9590
IS - 3
ER -