Blood endothelin-1 and cold-induced vasodilation in patients with primary Raynauld's phenomenon and workers with vibration-induced white finger

Hiro Nakamura, I. Matsuzaki, K. Hatta, H. Nagase, Y. Nobokuni, Y. Kambayashi, Keiki Ogino

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Aim. Cold water-immersion induces vasoconstriction with an elevation of blood endothelin-1, which is a potent vasoconstrictor peptide, in patients with primary Raynaud's phenomenon (PRP). However, physiological involvement of endothelin-1 in cold-induced vasodilation (CIVD) remains to be elucidated. Methods. We monitored changes of finger blood flow during cold water (10°C) immersion and assayed blood endothelin-1 in 7 PRP patients and 7 workers with vibration-induced white finger (VWF) and in the respective control subjects. Results. While significant reductions in finger blood flow at 2 min after the immersion were observed in PRP patients and VWF workers, its elevation at 4 min, which was considered to reflect CIVD, was recognized only in PRP patients. In healthy controls, blood endothelin-1 increased at 4 min and returned to the basal level immediately after the immersion. The increase in blood endothelin-1 at 4 min in PRP patients was greater than that in controls, and continued even after the immersion. Conversely, the increase neither at 4 min nor after immersion was seen in VWF workers. Local vascular changes produced by repetitive vibration may be responsible for the attenuated CIVD and unchanged blood endothelin-1 during cold water-immersion in VWF workers. Conclusion. Our results showing elevated blood endothelin-1 during and after immersion in PRP contrast with that in VWF suggesting that endothelin-1 is related to sympathetic hyperactivity which is more involved in PRP rather than VWF. It seems unlikely that endothelin-1 is functionally or directly associated with CIVD.

Original languageEnglish
Pages (from-to)243-249
Number of pages7
JournalInternational Angiology
Volume22
Issue number3
Publication statusPublished - Sep 2003
Externally publishedYes

Fingerprint

Endothelin-1
Vibration
Vasodilation
Raynaud Disease
Immersion
Fingers
Water
Vasoconstrictor Agents
Vasoconstriction
Blood Vessels
Peptides

Keywords

  • Arterio-venous anastomosis
  • Blood pressure
  • Cold
  • Fingers
  • Sympathetic nervous system
  • Vasoconstriction

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Nakamura, H., Matsuzaki, I., Hatta, K., Nagase, H., Nobokuni, Y., Kambayashi, Y., & Ogino, K. (2003). Blood endothelin-1 and cold-induced vasodilation in patients with primary Raynauld's phenomenon and workers with vibration-induced white finger. International Angiology, 22(3), 243-249.

Blood endothelin-1 and cold-induced vasodilation in patients with primary Raynauld's phenomenon and workers with vibration-induced white finger. / Nakamura, Hiro; Matsuzaki, I.; Hatta, K.; Nagase, H.; Nobokuni, Y.; Kambayashi, Y.; Ogino, Keiki.

In: International Angiology, Vol. 22, No. 3, 09.2003, p. 243-249.

Research output: Contribution to journalArticle

Nakamura, H, Matsuzaki, I, Hatta, K, Nagase, H, Nobokuni, Y, Kambayashi, Y & Ogino, K 2003, 'Blood endothelin-1 and cold-induced vasodilation in patients with primary Raynauld's phenomenon and workers with vibration-induced white finger', International Angiology, vol. 22, no. 3, pp. 243-249.
Nakamura, Hiro ; Matsuzaki, I. ; Hatta, K. ; Nagase, H. ; Nobokuni, Y. ; Kambayashi, Y. ; Ogino, Keiki. / Blood endothelin-1 and cold-induced vasodilation in patients with primary Raynauld's phenomenon and workers with vibration-induced white finger. In: International Angiology. 2003 ; Vol. 22, No. 3. pp. 243-249.
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AU - Nagase, H.

AU - Nobokuni, Y.

AU - Kambayashi, Y.

AU - Ogino, Keiki

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N2 - Aim. Cold water-immersion induces vasoconstriction with an elevation of blood endothelin-1, which is a potent vasoconstrictor peptide, in patients with primary Raynaud's phenomenon (PRP). However, physiological involvement of endothelin-1 in cold-induced vasodilation (CIVD) remains to be elucidated. Methods. We monitored changes of finger blood flow during cold water (10°C) immersion and assayed blood endothelin-1 in 7 PRP patients and 7 workers with vibration-induced white finger (VWF) and in the respective control subjects. Results. While significant reductions in finger blood flow at 2 min after the immersion were observed in PRP patients and VWF workers, its elevation at 4 min, which was considered to reflect CIVD, was recognized only in PRP patients. In healthy controls, blood endothelin-1 increased at 4 min and returned to the basal level immediately after the immersion. The increase in blood endothelin-1 at 4 min in PRP patients was greater than that in controls, and continued even after the immersion. Conversely, the increase neither at 4 min nor after immersion was seen in VWF workers. Local vascular changes produced by repetitive vibration may be responsible for the attenuated CIVD and unchanged blood endothelin-1 during cold water-immersion in VWF workers. Conclusion. Our results showing elevated blood endothelin-1 during and after immersion in PRP contrast with that in VWF suggesting that endothelin-1 is related to sympathetic hyperactivity which is more involved in PRP rather than VWF. It seems unlikely that endothelin-1 is functionally or directly associated with CIVD.

AB - Aim. Cold water-immersion induces vasoconstriction with an elevation of blood endothelin-1, which is a potent vasoconstrictor peptide, in patients with primary Raynaud's phenomenon (PRP). However, physiological involvement of endothelin-1 in cold-induced vasodilation (CIVD) remains to be elucidated. Methods. We monitored changes of finger blood flow during cold water (10°C) immersion and assayed blood endothelin-1 in 7 PRP patients and 7 workers with vibration-induced white finger (VWF) and in the respective control subjects. Results. While significant reductions in finger blood flow at 2 min after the immersion were observed in PRP patients and VWF workers, its elevation at 4 min, which was considered to reflect CIVD, was recognized only in PRP patients. In healthy controls, blood endothelin-1 increased at 4 min and returned to the basal level immediately after the immersion. The increase in blood endothelin-1 at 4 min in PRP patients was greater than that in controls, and continued even after the immersion. Conversely, the increase neither at 4 min nor after immersion was seen in VWF workers. Local vascular changes produced by repetitive vibration may be responsible for the attenuated CIVD and unchanged blood endothelin-1 during cold water-immersion in VWF workers. Conclusion. Our results showing elevated blood endothelin-1 during and after immersion in PRP contrast with that in VWF suggesting that endothelin-1 is related to sympathetic hyperactivity which is more involved in PRP rather than VWF. It seems unlikely that endothelin-1 is functionally or directly associated with CIVD.

KW - Arterio-venous anastomosis

KW - Blood pressure

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KW - Fingers

KW - Sympathetic nervous system

KW - Vasoconstriction

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