Blood-compatible ceramic particles, coating layers, and macrospheres for blood purification and related applications

Takuji Asano, Tomohiko Yoshioka, Yuki Shirosaki, Kanji Tsuru, Satoshi Hayakawa, Akiyoshi Osaka

Research output: Chapter in Book/Report/Conference proceedingChapter


Current apheresis or blood purification practices depend primarily on polymer systems that enable filtering and adsorbing pathogenic substances in blood: the latter consist of base polymer-based carriers and active ligands. However, some ceramic materials, such as silica, titania, and hydroxyapatite, are known to be blood compatible. The research on their use for apheresis is very small in comparison to the polymer systems, but the ceramic-based materials have been steadily discussed until now. This article aims to provide some feasible ideas and strategies together with their microstructures for further apheresis applications. After blood clotting pathways and apheresis practice, several blood-compatible materials in the form of particles, coatings (layers), and macrospheres are introduced. In addition, the materials for stent applications are also mentioned because the highest blood compatibility is demanded. Examples of bilirubin, b2-microglobulin (B2M), bovine serum albumin (BSA), and lysozyme (LYZ) adsorption on titania gel particles, Zn-substituted hydroxyapatite, and so-gel derived silica macrospheres are presented.

Original languageEnglish
Title of host publicationBioceramics
Subtitle of host publicationFrom Macro to Nanoscale
Number of pages49
ISBN (Electronic)9780081029992
ISBN (Print)9780081030004
Publication statusPublished - Jan 1 2020


  • b2-microglobulin
  • Bilirubin
  • Blood compatible
  • Coating
  • Ion-substituted hydroxyapatite
  • Macrospheres
  • Particles
  • Silica gel

ASJC Scopus subject areas

  • Engineering(all)
  • Materials Science(all)


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