Blood compatibility of stainless-steel and titanium immobilized with alginic acid layers

Tomohiko Yoshioka, Kanji Tsuru, Satoshi Hayakawa, Akiyoshi Osaka

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2 Citations (Scopus)

Abstract

γ-Aminopropyltriethoxysilane (γ-APS) was grafted on stainless-steel and titanium substrates, and subsequently alginic acid layer was immobilized on them. Their surfaces were characterized with X-ray photoelectron spectroscopy (XPS) and contact angle measurement. Blood compatibility of thus obtained substrates was evaluated in terms of both the number of the adhered platelets and blood clotting factors for plasma contacted with the substrates such as active partial thromboplastin time (PTT), prothrombin time (PT), and amount of fibrinogen (Fib). The steel and titanium substrates with alginic acid layer did not affect blood clotting factors. In vitro platelet adhesion assay indicated that those substrates adhered less number of platelets than non-treated substrates. Hence the alginic acid immobilization leads to blood compatible surfaces.

Original languageEnglish
Title of host publicationMaterials Research Society Symposium - Proceedings
EditorsE. Manias, G.G. Malliaras
Pages333-338
Number of pages6
Volume734
Publication statusPublished - 2003
EventPolymer/Metal Interfaces and Defect Mediated Phenomena in Ordered Polymers - Boston, MA, United States
Duration: Dec 2 2002Dec 6 2002

Other

OtherPolymer/Metal Interfaces and Defect Mediated Phenomena in Ordered Polymers
CountryUnited States
CityBoston, MA
Period12/2/0212/6/02

Fingerprint

Alginate
Stainless Steel
Titanium
Blood
Stainless steel
Substrates
Platelets
Blood Coagulation Factors
Steel
Thromboplastin
Prothrombin
Angle measurement
Fibrinogen
Contact angle
alginic acid
Assays
Adhesion
X ray photoelectron spectroscopy
Plasmas

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials

Cite this

Yoshioka, T., Tsuru, K., Hayakawa, S., & Osaka, A. (2003). Blood compatibility of stainless-steel and titanium immobilized with alginic acid layers. In E. Manias, & G. G. Malliaras (Eds.), Materials Research Society Symposium - Proceedings (Vol. 734, pp. 333-338)

Blood compatibility of stainless-steel and titanium immobilized with alginic acid layers. / Yoshioka, Tomohiko; Tsuru, Kanji; Hayakawa, Satoshi; Osaka, Akiyoshi.

Materials Research Society Symposium - Proceedings. ed. / E. Manias; G.G. Malliaras. Vol. 734 2003. p. 333-338.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Yoshioka, T, Tsuru, K, Hayakawa, S & Osaka, A 2003, Blood compatibility of stainless-steel and titanium immobilized with alginic acid layers. in E Manias & GG Malliaras (eds), Materials Research Society Symposium - Proceedings. vol. 734, pp. 333-338, Polymer/Metal Interfaces and Defect Mediated Phenomena in Ordered Polymers, Boston, MA, United States, 12/2/02.
Yoshioka T, Tsuru K, Hayakawa S, Osaka A. Blood compatibility of stainless-steel and titanium immobilized with alginic acid layers. In Manias E, Malliaras GG, editors, Materials Research Society Symposium - Proceedings. Vol. 734. 2003. p. 333-338
Yoshioka, Tomohiko ; Tsuru, Kanji ; Hayakawa, Satoshi ; Osaka, Akiyoshi. / Blood compatibility of stainless-steel and titanium immobilized with alginic acid layers. Materials Research Society Symposium - Proceedings. editor / E. Manias ; G.G. Malliaras. Vol. 734 2003. pp. 333-338
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