Blood compatibility of organic-inorganic biomedical materials

Akiyoshi Osaka; Tomohiko Yoshioka; Takeshi Yabuta; Kanji Tsuru; Satoshi Hayakawa

doi:10.4028/0-87849-961-x.713

Blood compatibility of organic-inorganic biomedical materials

Akiyoshi Osaka, Tomohiko Yoshioka, Takeshi Yabuta, Kanji Tsuru, Satoshi Hayakawa

Research output: Contribution to journal › Article › peer-review

Abstract

Organic-inorganic hybrids involving Ti-O bonds were coated on stainless-steel (SUS316L) substrates. Tetraisopropoxide and titanium methacrylate triisopropoxide were employed as the major starting chemicals to provide TiO₂-polydimethylsiloxane (PDMS) layers or organotitanium molecular thin layers, respectively. Fourier transform infrared spectra indicated that each layer contained Ti-O bonds in their structure. The obtained hybrid layers had little effects on the blood-clotting times such as active partial thromboplastin time and pro thrombin time. In addition, the number of adhered platelet on the TiO₂-PDMS layers depended on the composition, while the organotitanium molecular thin layers suppressed fibrinogen adsorption compared with coating-free SUS 316L substrate.

Original language	English
Pages (from-to)	713-716
Number of pages	4
Journal	Key Engineering Materials
Volume	284-286
DOIs	https://doi.org/10.4028/0-87849-961-x.713
Publication status	Published - Jan 1 2005

Keywords

Blood compatibility
Organic-inorganic hybrids
Titanium oxide

ASJC Scopus subject areas

Materials Science(all)
Mechanics of Materials
Mechanical Engineering

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10.4028/0-87849-961-x.713

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title = "Blood compatibility of organic-inorganic biomedical materials",

abstract = "Organic-inorganic hybrids involving Ti-O bonds were coated on stainless-steel (SUS316L) substrates. Tetraisopropoxide and titanium methacrylate triisopropoxide were employed as the major starting chemicals to provide TiO2-polydimethylsiloxane (PDMS) layers or organotitanium molecular thin layers, respectively. Fourier transform infrared spectra indicated that each layer contained Ti-O bonds in their structure. The obtained hybrid layers had little effects on the blood-clotting times such as active partial thromboplastin time and pro thrombin time. In addition, the number of adhered platelet on the TiO2-PDMS layers depended on the composition, while the organotitanium molecular thin layers suppressed fibrinogen adsorption compared with coating-free SUS 316L substrate.",

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T1 - Blood compatibility of organic-inorganic biomedical materials

AU - Osaka, Akiyoshi

AU - Yoshioka, Tomohiko

AU - Yabuta, Takeshi

AU - Tsuru, Kanji

AU - Hayakawa, Satoshi

PY - 2005/1/1

Y1 - 2005/1/1

N2 - Organic-inorganic hybrids involving Ti-O bonds were coated on stainless-steel (SUS316L) substrates. Tetraisopropoxide and titanium methacrylate triisopropoxide were employed as the major starting chemicals to provide TiO2-polydimethylsiloxane (PDMS) layers or organotitanium molecular thin layers, respectively. Fourier transform infrared spectra indicated that each layer contained Ti-O bonds in their structure. The obtained hybrid layers had little effects on the blood-clotting times such as active partial thromboplastin time and pro thrombin time. In addition, the number of adhered platelet on the TiO2-PDMS layers depended on the composition, while the organotitanium molecular thin layers suppressed fibrinogen adsorption compared with coating-free SUS 316L substrate.

AB - Organic-inorganic hybrids involving Ti-O bonds were coated on stainless-steel (SUS316L) substrates. Tetraisopropoxide and titanium methacrylate triisopropoxide were employed as the major starting chemicals to provide TiO2-polydimethylsiloxane (PDMS) layers or organotitanium molecular thin layers, respectively. Fourier transform infrared spectra indicated that each layer contained Ti-O bonds in their structure. The obtained hybrid layers had little effects on the blood-clotting times such as active partial thromboplastin time and pro thrombin time. In addition, the number of adhered platelet on the TiO2-PDMS layers depended on the composition, while the organotitanium molecular thin layers suppressed fibrinogen adsorption compared with coating-free SUS 316L substrate.

KW - Blood compatibility

KW - Organic-inorganic hybrids

KW - Titanium oxide

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Blood compatibility of organic-inorganic biomedical materials

Abstract

Keywords

ASJC Scopus subject areas

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