Blonanserin, an antipsychotic and dopamine D2/D3 receptor antagonist, and ameliorated alcohol dependence

Manabu Takaki, Hiroshi Ujike

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Blonanserin (BNS) is used for treatment of both positive and negative symptoms of schizophrenia in Japan and Korea. Because BNS has weak α1 receptor blocking activities and is almost devoid of histamine H1 and muscarinic M1 antagonist activity, BNS is better tolerated than other atypical antipsychotics. A high degree of D3 receptor blockage is reported to be predictive of drug abuse and alcoholism, and BNS has strong D3 receptor antagonism. Thus, BNS may be useful in the treatment of alcoholism. We present a case in which BNS ameliorated alcohol dependence.

Original languageEnglish
Pages (from-to)68-69
Number of pages2
JournalClinical Neuropharmacology
Volume36
Issue number2
DOIs
Publication statusPublished - Mar 2013

Fingerprint

Dopamine D3 Receptors
Antipsychotic Agents
Alcoholism
Muscarinic Antagonists
Korea
Histamine
Substance-Related Disorders
blonanserin
Dopamine D2 Receptor Antagonists
Schizophrenia
Japan

Keywords

  • alcohol dependence
  • blonanserin
  • D/D receptor antagonist
  • D receptor antagonist

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Pharmacology
  • Clinical Neurology

Cite this

Blonanserin, an antipsychotic and dopamine D2/D3 receptor antagonist, and ameliorated alcohol dependence. / Takaki, Manabu; Ujike, Hiroshi.

In: Clinical Neuropharmacology, Vol. 36, No. 2, 03.2013, p. 68-69.

Research output: Contribution to journalArticle

@article{2491dd594d274d45a4351dc19f492399,
title = "Blonanserin, an antipsychotic and dopamine D2/D3 receptor antagonist, and ameliorated alcohol dependence",
abstract = "Blonanserin (BNS) is used for treatment of both positive and negative symptoms of schizophrenia in Japan and Korea. Because BNS has weak α1 receptor blocking activities and is almost devoid of histamine H1 and muscarinic M1 antagonist activity, BNS is better tolerated than other atypical antipsychotics. A high degree of D3 receptor blockage is reported to be predictive of drug abuse and alcoholism, and BNS has strong D3 receptor antagonism. Thus, BNS may be useful in the treatment of alcoholism. We present a case in which BNS ameliorated alcohol dependence.",
keywords = "alcohol dependence, blonanserin, D/D receptor antagonist, D receptor antagonist",
author = "Manabu Takaki and Hiroshi Ujike",
year = "2013",
month = "3",
doi = "10.1097/WNF.0b013e318280028a",
language = "English",
volume = "36",
pages = "68--69",
journal = "Clinical Neuropharmacology",
issn = "0362-5664",
publisher = "Lippincott Williams and Wilkins",
number = "2",

}

TY - JOUR

T1 - Blonanserin, an antipsychotic and dopamine D2/D3 receptor antagonist, and ameliorated alcohol dependence

AU - Takaki, Manabu

AU - Ujike, Hiroshi

PY - 2013/3

Y1 - 2013/3

N2 - Blonanserin (BNS) is used for treatment of both positive and negative symptoms of schizophrenia in Japan and Korea. Because BNS has weak α1 receptor blocking activities and is almost devoid of histamine H1 and muscarinic M1 antagonist activity, BNS is better tolerated than other atypical antipsychotics. A high degree of D3 receptor blockage is reported to be predictive of drug abuse and alcoholism, and BNS has strong D3 receptor antagonism. Thus, BNS may be useful in the treatment of alcoholism. We present a case in which BNS ameliorated alcohol dependence.

AB - Blonanserin (BNS) is used for treatment of both positive and negative symptoms of schizophrenia in Japan and Korea. Because BNS has weak α1 receptor blocking activities and is almost devoid of histamine H1 and muscarinic M1 antagonist activity, BNS is better tolerated than other atypical antipsychotics. A high degree of D3 receptor blockage is reported to be predictive of drug abuse and alcoholism, and BNS has strong D3 receptor antagonism. Thus, BNS may be useful in the treatment of alcoholism. We present a case in which BNS ameliorated alcohol dependence.

KW - alcohol dependence

KW - blonanserin

KW - D/D receptor antagonist

KW - D receptor antagonist

UR - http://www.scopus.com/inward/record.url?scp=84875438606&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84875438606&partnerID=8YFLogxK

U2 - 10.1097/WNF.0b013e318280028a

DO - 10.1097/WNF.0b013e318280028a

M3 - Article

VL - 36

SP - 68

EP - 69

JO - Clinical Neuropharmacology

JF - Clinical Neuropharmacology

SN - 0362-5664

IS - 2

ER -