Blockin of cytotoxic T-cell function of MOLF/Ei mice by anti-Ly 35.1 monoclonal antibody

M. Mieno, H. Udono, S. Ikegami, N. Tada, H. Shiku, E. Nakayama

Research output: Contribution to journalArticlepeer-review

Abstract

Ly 35.1 antigen is an alloantigen expressed only on T cells of Mus musculus molossinus-derived inbred strains. Previous findings indicated that the genetic locus coding for Ly 35 antigen was closely linked to Ly 2/3 on chromosome 6 and that epitopes detected by Ly 2.1 and Ly 35.1 monoclonal antibodies (mAb) were closely associated, as shown by binding inhibition assay. In this study, we examined the blocking effects of anti-Ly 2.1 and anti-Ly 35.1 mAb on cytotoxic T-cell function of MOLF/Ei mice generated against BALB/c. MOLF/Ei cytotoxicity was blocked by Ly 35.1 mAb, but not by anti-Ly 2.1 mAb. Additional tests showed that cytotoxicity was blocked by Ly 3.1 mAb, but not Ly 3.2 or Ly 2.2 mAb. These results suggested that MOLF/Ei mice express Ly 3.1, but not Ly 2.1 antigen at a functional level, and that Ly 35.1 may be a functional epitope of Ly 2 antigen in the MOLF/Ei strain.

Original languageEnglish
Pages (from-to)431-433
Number of pages3
JournalImmunology
Volume68
Issue number3
Publication statusPublished - 1989
Externally publishedYes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Fingerprint Dive into the research topics of 'Blockin of cytotoxic T-cell function of MOLF/Ei mice by anti-Ly 35.1 monoclonal antibody'. Together they form a unique fingerprint.

Cite this