Abstract
Although chlorpromazine was shown to greatly inhibit a Ca2+-mediated cell death at favorable concentrations (10-6 ∼ 10-5 M), it caused a drastic decrease in cell viability at higher concentrations (10-4 ∼ 10-3 M) in a human neuroblastoma cell line. The toxic effect of chlorpromazine also occurred in Ca2+-free medium and was not parallel to the amount of thiobarbituric acid-reactive substances produced. These results indicate that chlorpromazine has biphasic effects on cell viability according to the concentrations added, i.e. a protective effect against cell damage caused by Ca2+, and a direct toxic effect independent of extracellular Ca2+ or of lipid peroxidation.
| Original language | English |
|---|---|
| Pages (from-to) | 335-339 |
| Number of pages | 5 |
| Journal | Neuroscience Letters |
| Volume | 71 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - Nov 21 1986 |
| Externally published | Yes |
Keywords
- Ca toxicity
- Cell viability
- Chlorpromazine
- Lipid peroxidation
- Neuroblastoma cell line
ASJC Scopus subject areas
- Neuroscience(all)
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Cite this
Abe, K., Sekizawa, T., & Kogure, K. (1986). Biphasic effects of chlorpromazine on cell viability in a neuroblastoma cell line. Neuroscience Letters, 71(3), 335-339. https://doi.org/10.1016/0304-3940(86)90643-9