Biphasic effects of chlorpromazine on cell viability in a neuroblastoma cell line

Koji Abe, Tsuyoshi Sekizawa, Kyuya Kogure

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Although chlorpromazine was shown to greatly inhibit a Ca2+-mediated cell death at favorable concentrations (10-6 ∼ 10-5 M), it caused a drastic decrease in cell viability at higher concentrations (10-4 ∼ 10-3 M) in a human neuroblastoma cell line. The toxic effect of chlorpromazine also occurred in Ca2+-free medium and was not parallel to the amount of thiobarbituric acid-reactive substances produced. These results indicate that chlorpromazine has biphasic effects on cell viability according to the concentrations added, i.e. a protective effect against cell damage caused by Ca2+, and a direct toxic effect independent of extracellular Ca2+ or of lipid peroxidation.

Original languageEnglish
Pages (from-to)335-339
Number of pages5
JournalNeuroscience Letters
Volume71
Issue number3
DOIs
Publication statusPublished - Nov 21 1986
Externally publishedYes

Keywords

  • Ca toxicity
  • Cell viability
  • Chlorpromazine
  • Lipid peroxidation
  • Neuroblastoma cell line

ASJC Scopus subject areas

  • Neuroscience(all)

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