Biotransformation of a biosynthetic intermediate mimic of nonactin by Streptomyces griseus

Tadaatsu Hanadatea, Kentaro Takaia, Naoki Abe, Teiko Yamada, Shigefumi Kuwahara, Hiromasa Kiyota

Research output: Contribution to journalArticle

Abstract

A mimic of a plausible biosynthetic intermediate of bishomononactic acid, one of the monomers of macrotetrolide antibiotics (polynactin), was synthesized as a thiol ester. FAB-MS analysis showed that fermentation of polynactin producing Streptomyces griseus with the compound, afforded the unnatural polynactins containing bishomononactic acid(s).

Original languageEnglish
Pages (from-to)93-98
Number of pages6
JournalHeterocyclic Communications
Volume17
Issue number3-4
DOIs
Publication statusPublished - Sep 1 2011
Externally publishedYes

Keywords

  • Antibiotics
  • Biotransformation
  • Bishomononactic acid
  • Polynactin
  • Streptomyces griseus
  • Synthesis

ASJC Scopus subject areas

  • Organic Chemistry

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