Biosynthetic study of amphidinolide C

Takaaki Kubota, Masashi Tsuda, Jun'ichi Kobayashi

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24 Citations (Scopus)

Abstract

The biosynthetic origins of amphidinolide C (1) were investigated on the basis of 13C NMR data of 13C enriched samples obtained by feeding experiments with [1-13C], [2-13C], and [1,2-13C2] sodium acetates in cultures of a dinoflagellate Amphidinium sp. These incorporation patterns suggested that amphidinolide C (1) was generated from four diketide chains, four acetate units, five isolated C1 unit from C-2 of acetates, seven branched C1 units from C-2 of acetates, and a 'm-m' and a 'm-m-m' units derived only from C-2 of acetates.

Original languageEnglish
Pages (from-to)5975-5977
Number of pages3
JournalTetrahedron
Volume57
Issue number28
DOIs
Publication statusPublished - Jul 9 2001
Externally publishedYes

Keywords

  • Biosynthesis
  • Dinoflagellate
  • Macrolide

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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