Biosynthesis, mode of action, and functional significance of neurosteroids in the purkinje cell

Kazuyoshi Tsutsui, Kazuyoshi Ukena, Hirotaka Sakamoto, Shin Ichiro Okuyama, Shogo Haraguchi

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

The brain has traditionally been considered to be a target site of peripheral steroid hormones. In addition to this classical concept, we now know that the brain has the capacity to synthesize steroids de novo from cholesterol, the so-called "neurosteroids." In the middle 1990s, the Purkinje cell, an important cerebellar neuron, was identified as a major site for neurosteroid formation in the brain of mammals and other vertebrates. This discovery has provided the opportunity to understand neuronal neurosteroidogenesis in the brain. In addition, biological actions of neurosteroids are becoming clear by the studies using the Purkinje cell, an excellent cellular model, which is known to play an important role in memory and learning processes. Based on the studies on mammals over the past decade, it is considered that the Purkinje cell actively synthesizes progesterone and estradiol from cholesterol during neonatal life, when cerebellar neuronal circuit formation occurs. Both progesterone and estradiol promote dendritic growth, spinogenesis, and synaptogenesis via each cognate nuclear receptor in the developing Purkinje cell. Such neurosteroid actions mediated by neurotrophic factors may contribute to the formation of cerebellar neuronal circuit during neonatal life. 3α,5α-Tetrahydroprogesterone (allopregnanolone), a progesterone metabolite, is also synthesized in the cerebellum and considered to act as a survival factor of Purkinje cells in the neonate. This review summarizes the current knowledge regarding the biosynthesis, mode of action, and functional significance of neurosteroids in the Purkinje cell during development in terms of synaptic formation of cerebellar neuronal networks.

Original languageEnglish
Article numberArticle 61
JournalFrontiers in Endocrinology
Volume2
Issue numberOCT
DOIs
Publication statusPublished - 2011
Externally publishedYes

Fingerprint

Purkinje Cells
Neurotransmitter Agents
Progesterone
Brain
Mammals
Estradiol
Steroids
Cholesterol
Pregnanolone
Nerve Growth Factors
Cytoplasmic and Nuclear Receptors
Cerebellum
Vertebrates
Learning
Hormones
Neurons
Growth

Keywords

  • Allopregnanolone
  • Dendritic growth
  • Estradiol
  • Neuronal circui
  • Neurosteroids
  • Progesterone
  • Purkinje cell
  • Synaptogenesis

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism

Cite this

Biosynthesis, mode of action, and functional significance of neurosteroids in the purkinje cell. / Tsutsui, Kazuyoshi; Ukena, Kazuyoshi; Sakamoto, Hirotaka; Okuyama, Shin Ichiro; Haraguchi, Shogo.

In: Frontiers in Endocrinology, Vol. 2, No. OCT, Article 61, 2011.

Research output: Contribution to journalArticle

Tsutsui, Kazuyoshi ; Ukena, Kazuyoshi ; Sakamoto, Hirotaka ; Okuyama, Shin Ichiro ; Haraguchi, Shogo. / Biosynthesis, mode of action, and functional significance of neurosteroids in the purkinje cell. In: Frontiers in Endocrinology. 2011 ; Vol. 2, No. OCT.
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