Bioresorbability of chelate-setting calcium-phosphate cement hybridized with gelatin particles using a porcine tibial defect model

Keishi Kiminami, Kohei Nagata, Toshiisa Konishi, Minori Mizumoto, Michiyo Honda, Kazuaki Nakano, Masaki Nagaya, Hidetoshi Arimura, Hiroshi Nagashima, Mamoru Aizawa

Research output: Contribution to journalArticle

Abstract

Calcium-phosphate cements (CPCs) are widely used to reconstruct and augment bones. To enhance the clinical usefulness of these cements, researchers have put great effort into improving their material properties and bioresorbability. To create a novel bioresorbable CPC, we successfully incorporated gelatin particles into a chelate-setting CPC, whose powder component consisted of hydroxyapatite surface-modified with inositol hexaphosphate and ¡-tricalcium phosphate. We expected that interconnected macropores could be formed inside the cement specimen through the degradation of the gelatin particles, resulting in cellular infiltration, specimen bioresorption, and subsequent new bone formation. To verify this hypothesis, we evaluated the bioresorbability and bone-forming ability of a gelatin-hybridized CPC implanted for eight weeks into porcine tibial defects. We also assessed the effects on the bioresorbability of polysaccharides (chitosan and chondroitin 6-sulfate) included in the liquid component of the CPC. Micro-CT observations and histological evaluations revealed that the use of chondroitin 6-sulfate could lead to enhancement of the bioresorbability and bone-forming ability. Of special note, the resorption rate reached nearly 85%, and new bone was observed at the resorbed sites inside the specimen. We conclude that gelatin-hybridized chelate-setting CPC containing chondroitin 6-sulfate is a promising bone substitute for non-load-bearing applications.

Original languageEnglish
Pages (from-to)71-78
Number of pages8
JournalJournal of the Ceramic Society of Japan
Volume126
Issue number2
DOIs
Publication statusPublished - Feb 2018

Keywords

  • Bioresorbability
  • Calcium-phosphate cement
  • Chelate-setting cement
  • Gelatin particles
  • Inositol phosphate
  • Porcine tibial defect

ASJC Scopus subject areas

  • Ceramics and Composites
  • Chemistry(all)
  • Condensed Matter Physics
  • Materials Chemistry

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  • Cite this

    Kiminami, K., Nagata, K., Konishi, T., Mizumoto, M., Honda, M., Nakano, K., Nagaya, M., Arimura, H., Nagashima, H., & Aizawa, M. (2018). Bioresorbability of chelate-setting calcium-phosphate cement hybridized with gelatin particles using a porcine tibial defect model. Journal of the Ceramic Society of Japan, 126(2), 71-78. https://doi.org/10.2109/jcersj2.17197