Biomarkers of oxidative/nitrosative stress: An approach to disease prevention

Keiki Ogino, Da Hong Wang

Research output: Contribution to journalArticle

66 Citations (Scopus)

Abstract

Oxidative/nitrosative stress is responsible for a variety of degenerative processes in some human diseases. Measurement of oxidatively/nitrosatively modified DNA, proteins, lipids, and sugars in biological samples has been expected to detect appropriate biomarkers for diseases in which reactive oxygen/nitrogen species are involved. Recently, the application of these biomarkers to epidemiological studies has resulted in a new discipline, molecular epidemiology, which provides the opportunity for better understanding of their causal relation with disease outcomes in a population level. In this brief review, we cover some specific biomarkers of oxidative/nitrosative stress with regard to the commonly used analytical methods for these biomarkers, their integration with epidemiology, and their application in antioxidant intervention trials, with an emphasis on those applicable to human studies and their potentialities for disease prevention. Copyright

Original languageEnglish
Pages (from-to)181-189
Number of pages9
JournalActa Medica Okayama
Volume61
Issue number4
Publication statusPublished - Aug 2007

Fingerprint

Oxidative stress
Biomarkers
Oxidative Stress
Reactive Nitrogen Species
Epidemiology
Molecular Epidemiology
Sugars
Epidemiologic Studies
Reactive Oxygen Species
Nitrogen
Antioxidants
Oxygen
Lipids
DNA
Population
Proteins

Keywords

  • Biomarker
  • Disease prevention
  • Molecular epidemiology
  • Oxidative/nitrosative stress

ASJC Scopus subject areas

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Biomarkers of oxidative/nitrosative stress : An approach to disease prevention. / Ogino, Keiki; Wang, Da Hong.

In: Acta Medica Okayama, Vol. 61, No. 4, 08.2007, p. 181-189.

Research output: Contribution to journalArticle

Ogino, Keiki ; Wang, Da Hong. / Biomarkers of oxidative/nitrosative stress : An approach to disease prevention. In: Acta Medica Okayama. 2007 ; Vol. 61, No. 4. pp. 181-189.
@article{aec6193bdbc044eea75a35ec628a092d,
title = "Biomarkers of oxidative/nitrosative stress: An approach to disease prevention",
abstract = "Oxidative/nitrosative stress is responsible for a variety of degenerative processes in some human diseases. Measurement of oxidatively/nitrosatively modified DNA, proteins, lipids, and sugars in biological samples has been expected to detect appropriate biomarkers for diseases in which reactive oxygen/nitrogen species are involved. Recently, the application of these biomarkers to epidemiological studies has resulted in a new discipline, molecular epidemiology, which provides the opportunity for better understanding of their causal relation with disease outcomes in a population level. In this brief review, we cover some specific biomarkers of oxidative/nitrosative stress with regard to the commonly used analytical methods for these biomarkers, their integration with epidemiology, and their application in antioxidant intervention trials, with an emphasis on those applicable to human studies and their potentialities for disease prevention. Copyright",
keywords = "Biomarker, Disease prevention, Molecular epidemiology, Oxidative/nitrosative stress",
author = "Keiki Ogino and Wang, {Da Hong}",
year = "2007",
month = "8",
language = "English",
volume = "61",
pages = "181--189",
journal = "Acta Medica Okayama",
issn = "0386-300X",
publisher = "Okayama University",
number = "4",

}

TY - JOUR

T1 - Biomarkers of oxidative/nitrosative stress

T2 - An approach to disease prevention

AU - Ogino, Keiki

AU - Wang, Da Hong

PY - 2007/8

Y1 - 2007/8

N2 - Oxidative/nitrosative stress is responsible for a variety of degenerative processes in some human diseases. Measurement of oxidatively/nitrosatively modified DNA, proteins, lipids, and sugars in biological samples has been expected to detect appropriate biomarkers for diseases in which reactive oxygen/nitrogen species are involved. Recently, the application of these biomarkers to epidemiological studies has resulted in a new discipline, molecular epidemiology, which provides the opportunity for better understanding of their causal relation with disease outcomes in a population level. In this brief review, we cover some specific biomarkers of oxidative/nitrosative stress with regard to the commonly used analytical methods for these biomarkers, their integration with epidemiology, and their application in antioxidant intervention trials, with an emphasis on those applicable to human studies and their potentialities for disease prevention. Copyright

AB - Oxidative/nitrosative stress is responsible for a variety of degenerative processes in some human diseases. Measurement of oxidatively/nitrosatively modified DNA, proteins, lipids, and sugars in biological samples has been expected to detect appropriate biomarkers for diseases in which reactive oxygen/nitrogen species are involved. Recently, the application of these biomarkers to epidemiological studies has resulted in a new discipline, molecular epidemiology, which provides the opportunity for better understanding of their causal relation with disease outcomes in a population level. In this brief review, we cover some specific biomarkers of oxidative/nitrosative stress with regard to the commonly used analytical methods for these biomarkers, their integration with epidemiology, and their application in antioxidant intervention trials, with an emphasis on those applicable to human studies and their potentialities for disease prevention. Copyright

KW - Biomarker

KW - Disease prevention

KW - Molecular epidemiology

KW - Oxidative/nitrosative stress

UR - http://www.scopus.com/inward/record.url?scp=34848827135&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=34848827135&partnerID=8YFLogxK

M3 - Article

C2 - 17726507

AN - SCOPUS:34848827135

VL - 61

SP - 181

EP - 189

JO - Acta Medica Okayama

JF - Acta Medica Okayama

SN - 0386-300X

IS - 4

ER -