[Biomarker for colorectal cancer].

Takeshi Nagasaka, Yoshiko Mori, Yuzo Umeda, Toshiyoshi Fujiwara

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Discovery of usable molecular biomarkers is the step closer to a realization of personalized therapy for patients with colorectal cancer(CRC). Herein we present an update of the most recent data on promising biological prognostic and/or predictive markers, including microsatellite instability(MSI) and KRAS/BRAF mutations. Additionally, we propose a new genetic classification for CRC based on MSI and KRAS/BRAF mutation status (a 2 x 3 matrix). The 2 x 3 matrix is constructed of 6 cells that are made by [MSI/non-MSI] x [BRAF mutant/KRAS mutant/wild type of the both genes]. All of CRC including Lynch syndrome could be classified without overlapping into the 6 cells. More interestingly, each cell has each promising biological prognostic and/or predictive feature, which will help clinicians to make personalized treatment strategy for each CRC patient.

Original languageEnglish
Pages (from-to)802-808
Number of pages7
JournalNihon rinsho. Japanese journal of clinical medicine
Volume70
Issue number5
Publication statusPublished - May 2012

ASJC Scopus subject areas

  • Medicine(all)

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