Context: Drug-induced phospholipidosis is one of the significant concerns in drug development, especially in safety assessment and noninvasive diagnostic tool is highly desirable. Objective: The objective of this study is to explored novel biomarkers for phospholipidosis using a metabolomic approach. Method: NMR spectrometry and LC/MS/MS analyses were applied to urine and plasma of rats administrated cationic amphiphilic drugs. Results: The phenylacetylglycine to hippuric acid ratio in plasma was increased in time and dose-dependent manners; and it was well correlated with histopathological observation. Conclusion: The plasma phenylacetylglycine to hippuric acid ratio is a potential marker in monitoring drug-induced phospholipidosis.
- drug-induced phospholipidosis
- hippuric acid
- phenylalanine metabolism
ASJC Scopus subject areas
- Clinical Biochemistry
- Health, Toxicology and Mutagenesis