Biomarker discovery for drug-induced phospholipidosis: phenylacetylglycine to hippuric acid ratio in urine and plasma as potential markers

Hidenori Kamiguchi, Mika Murabayashi, Ikuo Mori, Akira Horinouchi, Kazutaka Higaki

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Context: Drug-induced phospholipidosis is one of the significant concerns in drug development, especially in safety assessment and noninvasive diagnostic tool is highly desirable. Objective: The objective of this study is to explored novel biomarkers for phospholipidosis using a metabolomic approach. Method: NMR spectrometry and LC/MS/MS analyses were applied to urine and plasma of rats administrated cationic amphiphilic drugs. Results: The phenylacetylglycine to hippuric acid ratio in plasma was increased in time and dose-dependent manners; and it was well correlated with histopathological observation. Conclusion: The plasma phenylacetylglycine to hippuric acid ratio is a potential marker in monitoring drug-induced phospholipidosis.

Original languageEnglish
Pages (from-to)178-188
Number of pages11
JournalBiomarkers
Volume22
Issue number2
DOIs
Publication statusPublished - Feb 17 2017

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Keywords

  • drug-induced phospholipidosis
  • hippuric acid
  • Phenylacetylglycine
  • phenylalanine metabolism

ASJC Scopus subject areas

  • Biochemistry
  • Clinical Biochemistry
  • Health, Toxicology and Mutagenesis

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