Biological functions of glucan-binding protein B of Streptococcus mutans

K. Fujita, Michiyo Nakano, S. Inagaki, T. Ooshima

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Introduction: Streptococcus mutans has been implicated as a major causative agent of dental caries in humans. Bacterial components associated with the adhesion phase of S. mutans include glucosyltransferases, protein antigen C and proteins that bind glucan. At least four glucan-binding proteins (Gbp) have been identified; GbpA, GbpB, GbpC and GbpD. Methods: In our previous study, the contributions of GbpA and GbpC to the virulence of S. mutans were investigated; however, the biological function of GbpB and its role in the virulence of S. mutans remain to be elucidated. Using a GbpB-deficient mutant strain (BD1), we demonstrated in the present study that GbpB has a role in the biology of S. mutans. Results: The growth rate of BD1 was lower than that of other strains, while it was also shown to be less susceptible to phagocytosis and to form longer chains than the parental strain MT8148. In addition, electron microscope observations of the cell surfaces of BD1 showed that the cell-wall layers were obscure. Conclusion: These results suggest that GbpB may have an important role in cell-wall construction and be involved in cell separation and cell maintenance.

Original languageEnglish
Pages (from-to)289-292
Number of pages4
JournalOral Microbiology and Immunology
Volume22
Issue number5
DOIs
Publication statusPublished - Oct 2007
Externally publishedYes

Fingerprint

Streptococcus mutans
Cell Wall
Virulence
Glucosyltransferases
Glucans
Cell Separation
Dental Caries
Protein C
Phagocytosis
Maintenance
Streptococcus mutans IDG-60 protein
Electrons
Antigens
Growth
Proteins

Keywords

  • Cell wall
  • Glucan-binding protein B
  • Streptococcus mutans

ASJC Scopus subject areas

  • Immunology
  • Microbiology (medical)
  • Dentistry(all)

Cite this

Biological functions of glucan-binding protein B of Streptococcus mutans. / Fujita, K.; Nakano, Michiyo; Inagaki, S.; Ooshima, T.

In: Oral Microbiology and Immunology, Vol. 22, No. 5, 10.2007, p. 289-292.

Research output: Contribution to journalArticle

Fujita, K. ; Nakano, Michiyo ; Inagaki, S. ; Ooshima, T. / Biological functions of glucan-binding protein B of Streptococcus mutans. In: Oral Microbiology and Immunology. 2007 ; Vol. 22, No. 5. pp. 289-292.
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