Biological activity of synthetic peptides analogous to heat-stable enterotoxin produced by Yersinia enterocolitica

Takashi Inoue, Jun Yukitake, Susumu Hara, Keinosuke Okamoto, Akio Miyama

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

3 peptides were synthesized chemically by following the primary structure of heat-stable enterotoxin (ST) produced by Yersinia enterocolitica. A peptide 1-30, having the whole sequence of 30 amino-acid residues, showed a ST activity similar to that of analogue peptide 15-30 composed of the C-terminal 16 amino acid residues. The c-GMP levels of L cells increased through an interaction with peptide 1-30 but not with peptide 15-30, while membranes isolated from broken L cells responded to both. Peptide 1-11, composed of the N-terminal 11 amino-acid residues, showed no biological activity.

Original languageEnglish
Pages (from-to)151-153
Number of pages3
JournalFEMS Microbiology Letters
Volume36
Issue number2-3
Publication statusPublished - 1986
Externally publishedYes

Fingerprint

Yersinia enterocolitica
Peptides
Amino Acids
heat-stable enterotoxin (Yersinia)
Amino Acid Sequence
Hot Temperature
Membranes

Keywords

  • heat-stable enterotoxin
  • synthetic peptide analogues
  • Yersinia enterocolitica

ASJC Scopus subject areas

  • Microbiology
  • Medicine(all)
  • Molecular Biology
  • Genetics

Cite this

Biological activity of synthetic peptides analogous to heat-stable enterotoxin produced by Yersinia enterocolitica. / Inoue, Takashi; Yukitake, Jun; Hara, Susumu; Okamoto, Keinosuke; Miyama, Akio.

In: FEMS Microbiology Letters, Vol. 36, No. 2-3, 1986, p. 151-153.

Research output: Contribution to journalArticle

Inoue, Takashi ; Yukitake, Jun ; Hara, Susumu ; Okamoto, Keinosuke ; Miyama, Akio. / Biological activity of synthetic peptides analogous to heat-stable enterotoxin produced by Yersinia enterocolitica. In: FEMS Microbiology Letters. 1986 ; Vol. 36, No. 2-3. pp. 151-153.
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AU - Miyama, Akio

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