Biodistribution imaging of magnetic particles in mice: X-ray scanning analytical microscopy and magnetic resonance imaging

Shigeaki Abe; Ikuhiro Kida; Mitsue Esaki; Tsukasa Akasaka; Motohiro Uo; Toshiaki Hosono; Yoshinori Sato; Balachandran Jeyadevan; Yoshinori Kuboki; Manabu Morita; Kazuyuki Tohji; Fumio Watari

doi:10.3233/BME-2009-0583

Biodistribution imaging of magnetic particles in mice: X-ray scanning analytical microscopy and magnetic resonance imaging

Shigeaki Abe, Ikuhiro Kida, Mitsue Esaki, Tsukasa Akasaka, Motohiro Uo, Toshiaki Hosono, Yoshinori Sato, Balachandran Jeyadevan, Yoshinori Kuboki, Manabu Morita, Kazuyuki Tohji, Fumio Watari

Research output: Contribution to journal › Article

9 Citations (Scopus)

Abstract

Nano-sized particles have received much attention in view of their varied application in a wide range of fields. For example, magnetite (Fe ₃O₄) nanoparticles have been investigated for various medical applications. In this study, we visualized the distribution of administered magnetic nanoparticles in mice using both X-ray scanning analytical microscopy (XSAM) and magnetic resonance imaging (MRI). After administration, the nanoparticles were rapidly dispersed via the blood circulation, and reached the liver, kidney and spleen. Using the XSAM and MRI methods in a complementary fashion, the biodistribution of nano-sized magnetite particles was successfully visualized.

Original language	English
Pages (from-to)	213-220
Number of pages	8
Journal	Bio-Medical Materials and Engineering
Volume	19
Issue number	2-3
DOIs	https://doi.org/10.3233/BME-2009-0583
Publication status	Published - 2009

Keywords

Biodistribution
Magnetic resonance imaging
Nano magnetite

ASJC Scopus subject areas

Biomaterials
Biomedical Engineering

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Abe, S., Kida, I., Esaki, M., Akasaka, T., Uo, M., Hosono, T., Sato, Y., Jeyadevan, B., Kuboki, Y., Morita, M., Tohji, K., & Watari, F. (2009). Biodistribution imaging of magnetic particles in mice: X-ray scanning analytical microscopy and magnetic resonance imaging. Bio-Medical Materials and Engineering, 19(2-3), 213-220. https://doi.org/10.3233/BME-2009-0583

Biodistribution imaging of magnetic particles in mice : X-ray scanning analytical microscopy and magnetic resonance imaging. / Abe, Shigeaki; Kida, Ikuhiro; Esaki, Mitsue; Akasaka, Tsukasa; Uo, Motohiro; Hosono, Toshiaki; Sato, Yoshinori; Jeyadevan, Balachandran; Kuboki, Yoshinori; Morita, Manabu; Tohji, Kazuyuki; Watari, Fumio.

In: Bio-Medical Materials and Engineering, Vol. 19, No. 2-3, 2009, p. 213-220.

Research output: Contribution to journal › Article

Abe, Shigeaki ; Kida, Ikuhiro ; Esaki, Mitsue ; Akasaka, Tsukasa ; Uo, Motohiro ; Hosono, Toshiaki ; Sato, Yoshinori ; Jeyadevan, Balachandran ; Kuboki, Yoshinori ; Morita, Manabu ; Tohji, Kazuyuki ; Watari, Fumio. / Biodistribution imaging of magnetic particles in mice : X-ray scanning analytical microscopy and magnetic resonance imaging. In: Bio-Medical Materials and Engineering. 2009 ; Vol. 19, No. 2-3. pp. 213-220.

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