Biodistribution imaging of magnetic particles in mice: X-ray scanning analytical microscopy and magnetic resonance imaging

Shigeaki Abe; Ikuhiro Kida; Mitsue Esaki; Tsukasa Akasaka; Motohiro Uo; Toshiaki Hosono; Yoshinori Sato; Balachandran Jeyadevan; Yoshinori Kuboki; Manabu Morita; Kazuyuki Tohji; Fumio Watari

doi:10.3233/BME-2009-0583

Biodistribution imaging of magnetic particles in mice: X-ray scanning analytical microscopy and magnetic resonance imaging

Shigeaki Abe, Ikuhiro Kida, Mitsue Esaki, Tsukasa Akasaka, Motohiro Uo, Toshiaki Hosono, Yoshinori Sato, Balachandran Jeyadevan, Yoshinori Kuboki, Manabu Morita, Kazuyuki Tohji, Fumio Watari

Research output: Contribution to journal › Article › peer-review

10 Citations (Scopus)

Abstract

Nano-sized particles have received much attention in view of their varied application in a wide range of fields. For example, magnetite (Fe ₃O₄) nanoparticles have been investigated for various medical applications. In this study, we visualized the distribution of administered magnetic nanoparticles in mice using both X-ray scanning analytical microscopy (XSAM) and magnetic resonance imaging (MRI). After administration, the nanoparticles were rapidly dispersed via the blood circulation, and reached the liver, kidney and spleen. Using the XSAM and MRI methods in a complementary fashion, the biodistribution of nano-sized magnetite particles was successfully visualized.

Original language	English
Pages (from-to)	213-220
Number of pages	8
Journal	Bio-Medical Materials and Engineering
Volume	19
Issue number	2-3
DOIs	https://doi.org/10.3233/BME-2009-0583
Publication status	Published - 2009

Keywords

Biodistribution
Magnetic resonance imaging
Nano magnetite

ASJC Scopus subject areas

Biomaterials
Biomedical Engineering

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10.3233/BME-2009-0583

Cite this

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abstract = "Nano-sized particles have received much attention in view of their varied application in a wide range of fields. For example, magnetite (Fe 3O4) nanoparticles have been investigated for various medical applications. In this study, we visualized the distribution of administered magnetic nanoparticles in mice using both X-ray scanning analytical microscopy (XSAM) and magnetic resonance imaging (MRI). After administration, the nanoparticles were rapidly dispersed via the blood circulation, and reached the liver, kidney and spleen. Using the XSAM and MRI methods in a complementary fashion, the biodistribution of nano-sized magnetite particles was successfully visualized.",

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AU - Abe, Shigeaki

AU - Kida, Ikuhiro

AU - Esaki, Mitsue

AU - Akasaka, Tsukasa

AU - Uo, Motohiro

AU - Hosono, Toshiaki

AU - Sato, Yoshinori

AU - Jeyadevan, Balachandran

AU - Kuboki, Yoshinori

AU - Morita, Manabu

AU - Tohji, Kazuyuki

AU - Watari, Fumio

PY - 2009

Y1 - 2009

N2 - Nano-sized particles have received much attention in view of their varied application in a wide range of fields. For example, magnetite (Fe 3O4) nanoparticles have been investigated for various medical applications. In this study, we visualized the distribution of administered magnetic nanoparticles in mice using both X-ray scanning analytical microscopy (XSAM) and magnetic resonance imaging (MRI). After administration, the nanoparticles were rapidly dispersed via the blood circulation, and reached the liver, kidney and spleen. Using the XSAM and MRI methods in a complementary fashion, the biodistribution of nano-sized magnetite particles was successfully visualized.

AB - Nano-sized particles have received much attention in view of their varied application in a wide range of fields. For example, magnetite (Fe 3O4) nanoparticles have been investigated for various medical applications. In this study, we visualized the distribution of administered magnetic nanoparticles in mice using both X-ray scanning analytical microscopy (XSAM) and magnetic resonance imaging (MRI). After administration, the nanoparticles were rapidly dispersed via the blood circulation, and reached the liver, kidney and spleen. Using the XSAM and MRI methods in a complementary fashion, the biodistribution of nano-sized magnetite particles was successfully visualized.

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KW - Magnetic resonance imaging

KW - Nano magnetite

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Biodistribution imaging of magnetic particles in mice: X-ray scanning analytical microscopy and magnetic resonance imaging

Abstract

Keywords

ASJC Scopus subject areas

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