Biodistribution imaging of magnetic particles in mice: X-ray scanning analytical microscopy and magnetic resonance imaging

Shigeaki Abe; Ikuhiro Kida; Mitsue Esaki; Tsukasa Akasaka; Motohiro Uo; Toshiaki Hosono; Yoshinori Sato; Balachandran Jeyadevan; Yoshinori Kuboki; Manabu Morita; Kazuyuki Tohji; Fumio Watari

doi:10.3233/BME-2009-0583

Biodistribution imaging of magnetic particles in mice: X-ray scanning analytical microscopy and magnetic resonance imaging

Shigeaki Abe, Ikuhiro Kida, Mitsue Esaki, Tsukasa Akasaka, Motohiro Uo, Toshiaki Hosono, Yoshinori Sato, Balachandran Jeyadevan, Yoshinori Kuboki, Manabu Morita, Kazuyuki Tohji, Fumio Watari

Research output: Contribution to journal › Article › peer-review

9 Citations (Scopus)

Abstract

Nano-sized particles have received much attention in view of their varied application in a wide range of fields. For example, magnetite (Fe ₃O₄) nanoparticles have been investigated for various medical applications. In this study, we visualized the distribution of administered magnetic nanoparticles in mice using both X-ray scanning analytical microscopy (XSAM) and magnetic resonance imaging (MRI). After administration, the nanoparticles were rapidly dispersed via the blood circulation, and reached the liver, kidney and spleen. Using the XSAM and MRI methods in a complementary fashion, the biodistribution of nano-sized magnetite particles was successfully visualized.

Original language	English
Pages (from-to)	213-220
Number of pages	8
Journal	Bio-Medical Materials and Engineering
Volume	19
Issue number	2-3
DOIs	https://doi.org/10.3233/BME-2009-0583
Publication status	Published - 2009

Keywords

Biodistribution
Magnetic resonance imaging
Nano magnetite

ASJC Scopus subject areas

Biomaterials
Biomedical Engineering

Access to Document

10.3233/BME-2009-0583

Fingerprint Dive into the research topics of 'Biodistribution imaging of magnetic particles in mice: X-ray scanning analytical microscopy and magnetic resonance imaging'. Together they form a unique fingerprint.

Cite this

Biodistribution imaging of magnetic particles in mice : X-ray scanning analytical microscopy and magnetic resonance imaging. / Abe, Shigeaki; Kida, Ikuhiro; Esaki, Mitsue; Akasaka, Tsukasa; Uo, Motohiro; Hosono, Toshiaki; Sato, Yoshinori; Jeyadevan, Balachandran; Kuboki, Yoshinori; Morita, Manabu; Tohji, Kazuyuki; Watari, Fumio.

In: Bio-Medical Materials and Engineering, Vol. 19, No. 2-3, 2009, p. 213-220.

Research output: Contribution to journal › Article › peer-review

Abe, Shigeaki ; Kida, Ikuhiro ; Esaki, Mitsue ; Akasaka, Tsukasa ; Uo, Motohiro ; Hosono, Toshiaki ; Sato, Yoshinori ; Jeyadevan, Balachandran ; Kuboki, Yoshinori ; Morita, Manabu ; Tohji, Kazuyuki ; Watari, Fumio. / Biodistribution imaging of magnetic particles in mice : X-ray scanning analytical microscopy and magnetic resonance imaging. In: Bio-Medical Materials and Engineering. 2009 ; Vol. 19, No. 2-3. pp. 213-220.

@article{835447913b0345fe8d0afbaa586ecaa9,

title = "Biodistribution imaging of magnetic particles in mice: X-ray scanning analytical microscopy and magnetic resonance imaging",

abstract = "Nano-sized particles have received much attention in view of their varied application in a wide range of fields. For example, magnetite (Fe 3O4) nanoparticles have been investigated for various medical applications. In this study, we visualized the distribution of administered magnetic nanoparticles in mice using both X-ray scanning analytical microscopy (XSAM) and magnetic resonance imaging (MRI). After administration, the nanoparticles were rapidly dispersed via the blood circulation, and reached the liver, kidney and spleen. Using the XSAM and MRI methods in a complementary fashion, the biodistribution of nano-sized magnetite particles was successfully visualized.",

keywords = "Biodistribution, Magnetic resonance imaging, Nano magnetite",

author = "Shigeaki Abe and Ikuhiro Kida and Mitsue Esaki and Tsukasa Akasaka and Motohiro Uo and Toshiaki Hosono and Yoshinori Sato and Balachandran Jeyadevan and Yoshinori Kuboki and Manabu Morita and Kazuyuki Tohji and Fumio Watari",

year = "2009",

doi = "10.3233/BME-2009-0583",

language = "English",

volume = "19",

pages = "213--220",

journal = "Bio-Medical Materials and Engineering",

issn = "0959-2989",

publisher = "IOS Press",

number = "2-3",

}

TY - JOUR

T1 - Biodistribution imaging of magnetic particles in mice

T2 - X-ray scanning analytical microscopy and magnetic resonance imaging

AU - Abe, Shigeaki

AU - Kida, Ikuhiro

AU - Esaki, Mitsue

AU - Akasaka, Tsukasa

AU - Uo, Motohiro

AU - Hosono, Toshiaki

AU - Sato, Yoshinori

AU - Jeyadevan, Balachandran

AU - Kuboki, Yoshinori

AU - Morita, Manabu

AU - Tohji, Kazuyuki

AU - Watari, Fumio

PY - 2009

Y1 - 2009

N2 - Nano-sized particles have received much attention in view of their varied application in a wide range of fields. For example, magnetite (Fe 3O4) nanoparticles have been investigated for various medical applications. In this study, we visualized the distribution of administered magnetic nanoparticles in mice using both X-ray scanning analytical microscopy (XSAM) and magnetic resonance imaging (MRI). After administration, the nanoparticles were rapidly dispersed via the blood circulation, and reached the liver, kidney and spleen. Using the XSAM and MRI methods in a complementary fashion, the biodistribution of nano-sized magnetite particles was successfully visualized.

AB - Nano-sized particles have received much attention in view of their varied application in a wide range of fields. For example, magnetite (Fe 3O4) nanoparticles have been investigated for various medical applications. In this study, we visualized the distribution of administered magnetic nanoparticles in mice using both X-ray scanning analytical microscopy (XSAM) and magnetic resonance imaging (MRI). After administration, the nanoparticles were rapidly dispersed via the blood circulation, and reached the liver, kidney and spleen. Using the XSAM and MRI methods in a complementary fashion, the biodistribution of nano-sized magnetite particles was successfully visualized.

KW - Biodistribution

KW - Magnetic resonance imaging

KW - Nano magnetite

UR - http://www.scopus.com/inward/record.url?scp=67650863165&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=67650863165&partnerID=8YFLogxK

U2 - 10.3233/BME-2009-0583

DO - 10.3233/BME-2009-0583

M3 - Article

C2 - 19581716

AN - SCOPUS:67650863165

VL - 19

SP - 213

EP - 220

JO - Bio-Medical Materials and Engineering

JF - Bio-Medical Materials and Engineering

SN - 0959-2989

IS - 2-3

ER -