Biodistribution imaging of magnetic particles in mice: X-ray scanning analytical microscopy and magnetic resonance imaging

Shigeaki Abe, Ikuhiro Kida, Mitsue Esaki, Tsukasa Akasaka, Motohiro Uo, Toshiaki Hosono, Yoshinori Sato, Balachandran Jeyadevan, Yoshinori Kuboki, Manabu Morita, Kazuyuki Tohji, Fumio Watari

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Nano-sized particles have received much attention in view of their varied application in a wide range of fields. For example, magnetite (Fe 3O4) nanoparticles have been investigated for various medical applications. In this study, we visualized the distribution of administered magnetic nanoparticles in mice using both X-ray scanning analytical microscopy (XSAM) and magnetic resonance imaging (MRI). After administration, the nanoparticles were rapidly dispersed via the blood circulation, and reached the liver, kidney and spleen. Using the XSAM and MRI methods in a complementary fashion, the biodistribution of nano-sized magnetite particles was successfully visualized.

Original languageEnglish
Pages (from-to)213-220
Number of pages8
JournalBio-Medical Materials and Engineering
Volume19
Issue number2-3
DOIs
Publication statusPublished - 2009

Keywords

  • Biodistribution
  • Magnetic resonance imaging
  • Nano magnetite

ASJC Scopus subject areas

  • Biomaterials
  • Biomedical Engineering

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  • Cite this

    Abe, S., Kida, I., Esaki, M., Akasaka, T., Uo, M., Hosono, T., Sato, Y., Jeyadevan, B., Kuboki, Y., Morita, M., Tohji, K., & Watari, F. (2009). Biodistribution imaging of magnetic particles in mice: X-ray scanning analytical microscopy and magnetic resonance imaging. Bio-Medical Materials and Engineering, 19(2-3), 213-220. https://doi.org/10.3233/BME-2009-0583