Abstract
Nano-sized particles have received much attention in view of their varied application in a wide range of fields. For example, magnetite (Fe 3O4) nanoparticles have been investigated for various medical applications. In this study, we visualized the distribution of administered magnetic nanoparticles in mice using both X-ray scanning analytical microscopy (XSAM) and magnetic resonance imaging (MRI). After administration, the nanoparticles were rapidly dispersed via the blood circulation, and reached the liver, kidney and spleen. Using the XSAM and MRI methods in a complementary fashion, the biodistribution of nano-sized magnetite particles was successfully visualized.
| Original language | English |
|---|---|
| Pages (from-to) | 213-220 |
| Number of pages | 8 |
| Journal | Biomedical Materials and Engineering |
| Volume | 19 |
| Issue number | 2-3 |
| DOIs | |
| Publication status | Published - 2009 |
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Keywords
- Biodistribution
- Magnetic resonance imaging
- Nano magnetite
ASJC Scopus subject areas
- Biomedical Engineering
- Biomaterials
Cite this
Biodistribution imaging of magnetic particles in mice : X-ray scanning analytical microscopy and magnetic resonance imaging. / Abe, Shigeaki; Kida, Ikuhiro; Esaki, Mitsue; Akasaka, Tsukasa; Uo, Motohiro; Hosono, Toshiaki; Sato, Yoshinori; Jeyadevan, Balachandran; Kuboki, Yoshinori; Morita, Manabu; Tohji, Kazuyuki; Watari, Fumio.
In: Biomedical Materials and Engineering, Vol. 19, No. 2-3, 2009, p. 213-220.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Biodistribution imaging of magnetic particles in mice
T2 - X-ray scanning analytical microscopy and magnetic resonance imaging
AU - Abe, Shigeaki
AU - Kida, Ikuhiro
AU - Esaki, Mitsue
AU - Akasaka, Tsukasa
AU - Uo, Motohiro
AU - Hosono, Toshiaki
AU - Sato, Yoshinori
AU - Jeyadevan, Balachandran
AU - Kuboki, Yoshinori
AU - Morita, Manabu
AU - Tohji, Kazuyuki
AU - Watari, Fumio
PY - 2009
Y1 - 2009
N2 - Nano-sized particles have received much attention in view of their varied application in a wide range of fields. For example, magnetite (Fe 3O4) nanoparticles have been investigated for various medical applications. In this study, we visualized the distribution of administered magnetic nanoparticles in mice using both X-ray scanning analytical microscopy (XSAM) and magnetic resonance imaging (MRI). After administration, the nanoparticles were rapidly dispersed via the blood circulation, and reached the liver, kidney and spleen. Using the XSAM and MRI methods in a complementary fashion, the biodistribution of nano-sized magnetite particles was successfully visualized.
AB - Nano-sized particles have received much attention in view of their varied application in a wide range of fields. For example, magnetite (Fe 3O4) nanoparticles have been investigated for various medical applications. In this study, we visualized the distribution of administered magnetic nanoparticles in mice using both X-ray scanning analytical microscopy (XSAM) and magnetic resonance imaging (MRI). After administration, the nanoparticles were rapidly dispersed via the blood circulation, and reached the liver, kidney and spleen. Using the XSAM and MRI methods in a complementary fashion, the biodistribution of nano-sized magnetite particles was successfully visualized.
KW - Biodistribution
KW - Magnetic resonance imaging
KW - Nano magnetite
UR - http://www.scopus.com/inward/record.url?scp=67650863165&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=67650863165&partnerID=8YFLogxK
U2 - 10.3233/BME-2009-0583
DO - 10.3233/BME-2009-0583
M3 - Article
VL - 19
SP - 213
EP - 220
JO - Bio-Medical Materials and Engineering
JF - Bio-Medical Materials and Engineering
SN - 0959-2989
IS - 2-3
ER -