Biodegradable chitosan-silicate porous hybrids for drug delivery

Y. Shirosaki, K. Tsuru, Satoshi Hayakawa, A. Osaka

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Porous chitosan-silicate hybrids were prepared by freeze-drying the precursor sol solutions synthesized from chitosan and 3- glycidoxypropyltrimethoxysilane (GPTMS). Degradability of and the release of cytochrome C in to phosphate buffer saline solution (PBS) were examined as a function of the GPTMS content. The hybrids were less degradable with larger GPTMS contents, and the cytochrome C release profile was so controllable as to give either burst release or slow one due to the GPTMS content. Thus, the present porous chitosan-silicate hybrids were considered applicable to drug delivery systems.

Original languageEnglish
Pages (from-to)1219-1222
Number of pages4
JournalKey Engineering Materials
Volume361-363 II
Publication statusPublished - 2008

Fingerprint

Silicates
Chitosan
Drug delivery
Cytochromes
Proteins
Polymethyl Methacrylate
Sols
Sodium Chloride
Drying
Buffers
Phosphates

Keywords

  • Biodegradability
  • Chitosan
  • Chitosan-silicate hybrid
  • Drug delivery

ASJC Scopus subject areas

  • Ceramics and Composites
  • Chemical Engineering (miscellaneous)

Cite this

Shirosaki, Y., Tsuru, K., Hayakawa, S., & Osaka, A. (2008). Biodegradable chitosan-silicate porous hybrids for drug delivery. Key Engineering Materials, 361-363 II, 1219-1222.

Biodegradable chitosan-silicate porous hybrids for drug delivery. / Shirosaki, Y.; Tsuru, K.; Hayakawa, Satoshi; Osaka, A.

In: Key Engineering Materials, Vol. 361-363 II, 2008, p. 1219-1222.

Research output: Contribution to journalArticle

Shirosaki, Y, Tsuru, K, Hayakawa, S & Osaka, A 2008, 'Biodegradable chitosan-silicate porous hybrids for drug delivery', Key Engineering Materials, vol. 361-363 II, pp. 1219-1222.
Shirosaki, Y. ; Tsuru, K. ; Hayakawa, Satoshi ; Osaka, A. / Biodegradable chitosan-silicate porous hybrids for drug delivery. In: Key Engineering Materials. 2008 ; Vol. 361-363 II. pp. 1219-1222.
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