Biodegradable chitosan-silicate porous hybrids for drug delivery

Y. Shirosaki, K. Tsuru, S. Hayakawa, A. Osaka

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Porous chitosan-silicate hybrids were prepared by freeze-drying the precursor sol solutions synthesized from chitosan and 3- glycidoxypropyltrimethoxysilane (GPTMS). Degradability of and the release of cytochrome C in to phosphate buffer saline solution (PBS) were examined as a function of the GPTMS content. The hybrids were less degradable with larger GPTMS contents, and the cytochrome C release profile was so controllable as to give either burst release or slow one due to the GPTMS content. Thus, the present porous chitosan-silicate hybrids were considered applicable to drug delivery systems.

Original languageEnglish
Pages (from-to)1219-1222
Number of pages4
JournalKey Engineering Materials
Volume361-363 II
Publication statusPublished - Jan 1 2008

Keywords

  • Biodegradability
  • Chitosan
  • Chitosan-silicate hybrid
  • Drug delivery

ASJC Scopus subject areas

  • Materials Science(all)
  • Mechanics of Materials
  • Mechanical Engineering

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  • Cite this

    Shirosaki, Y., Tsuru, K., Hayakawa, S., & Osaka, A. (2008). Biodegradable chitosan-silicate porous hybrids for drug delivery. Key Engineering Materials, 361-363 II, 1219-1222.